Gene description for Egfr
Gene name	epidermal growth factor receptor
Gene symbol	Egfr
Other names/aliases	9030024J15Rik AI552599 Erbb Errb1 Errp Wa5 wa-2 wa2
Species	Mus musculus
Database cross references - Egfr
ExoCarta	ExoCarta_13649
Entrez Gene	13649
UniProt	Q01279
Egfr identified in exosomes derived from the following tissue/cell type
Brain cancer cells	19109410
Mast cells	17486113

Gene ontology annotations for Egfr

Molecular Function     glycoprotein binding GO:0001948 ISO     transferase activity GO:0016740 IEA     nitric-oxide synthase regulator activity GO:0030235 ISO     transmembrane signaling receptor activity GO:0004888 ISO     signal transducer activity GO:0004871 IDA     chromatin binding GO:0003682 ISO     enzyme binding GO:0019899 ISO     epidermal growth factor-activated receptor activity GO:0005006 ISO     epidermal growth factor binding GO:0048408 ISO     actin filament binding GO:0051015 ISO     nucleotide binding GO:0000166 IEA     ubiquitin protein ligase binding GO:0031625 ISO     receptor signaling protein tyrosine kinase activity GO:0004716 IEA     protein binding GO:0005515 IPI     transferase activity, transferring phosphorus-containing groups GO:0016772 IEA     ATP binding GO:0005524 IEA     integrin binding GO:0005178 ISO     protein tyrosine kinase activity GO:0004713 ISO     protein phosphatase binding GO:0019903 ISO     protein kinase binding GO:0019901 ISO     identical protein binding GO:0042802 ISO     transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA     kinase activity GO:0016301 IDA     protein kinase activity GO:0004672 IEA     receptor binding GO:0005102 ISO     protein heterodimerization activity GO:0046982 ISO Biological Process     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of catenin import into nucleus GO:0035413 ISO     embryonic placenta development GO:0001892 IMP     response to calcium ion GO:0051592 ISO     multicellular organismal development GO:0007275 IEA     epidermal growth factor receptor signaling pathway GO:0007173 ISO     cell proliferation GO:0008283 ISO     positive regulation of protein kinase B signaling GO:0051897 ISO     positive regulation of vasoconstriction GO:0045907 ISO     positive regulation of superoxide anion generation GO:0032930 ISO     negative regulation of mitotic cell cycle GO:0045930 ISO     cerebral cortex cell migration GO:0021795 IMP     negative regulation of apoptotic process GO:0043066 ISO     regulation of cell proliferation GO:0042127 IGI     activation of MAPKK activity GO:0000186 ISO     positive regulation of vasodilation GO:0045909 ISO     positive regulation of MAP kinase activity GO:0043406 ISO     translation GO:0006412 ISO     protein phosphorylation GO:0006468 IEA     learning or memory GO:0007611 ISO     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO     intracellular signal transduction GO:0035556 ISO     positive regulation of fibroblast proliferation GO:0048146 IMP     protein autophosphorylation GO:0046777 ISO     positive regulation of cell migration GO:0030335 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISO     positive regulation of DNA replication GO:0045740 ISO     response to UV-A GO:0070141 ISO     morphogenesis of an epithelial fold GO:0060571 IMP     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to estradiol stimulus GO:0071392 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     neuron projection morphogenesis GO:0048812 ISO     positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 ISO     ovulation cycle GO:0042698 ISO     regulation of nitric-oxide synthase activity GO:0050999 ISO     positive regulation of phosphorylation GO:0042327 ISO     positive regulation of cell proliferation GO:0008284 ISO     hair follicle development GO:0001942 IMP     positive regulation of epithelial cell proliferation GO:0050679 ISO     epidermis development GO:0008544 IMP     signal transduction GO:0007165 ISO     single organismal cell-cell adhesion GO:0016337 ISO     regulation of peptidyl-tyrosine phosphorylation GO:0050730 ISO     magnesium ion homeostasis GO:0010960 ISO     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA     positive regulation of inflammatory response GO:0050729 ISO     astrocyte activation GO:0048143 ISO     cell surface receptor signaling pathway GO:0007166 ISO     cell morphogenesis GO:0000902 IGI     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     cellular response to epidermal growth factor stimulus GO:0071364 ISO     negative regulation of protein catabolic process GO:0042177 ISO     phosphorylation GO:0016310 IEA     cellular response to amino acid stimulus GO:0071230 IDA     digestive tract morphogenesis GO:0048546 IMP     salivary gland morphogenesis GO:0007435 IMP     positive regulation of DNA repair GO:0045739 ISO Subcellular Localization     membrane raft GO:0045121 ISO     endosome GO:0005768 ISO     endosome membrane GO:0010008 ISO     cell surface GO:0009986 ISO     endocytic vesicle GO:0030139 ISO     early endosome membrane GO:0031901 ISO     basolateral plasma membrane GO:0016323 ISO     perinuclear region of cytoplasm GO:0048471 IDA     Golgi apparatus GO:0005794 IEA     focal adhesion GO:0005925 ISO     multivesicular body, internal vesicle lumen GO:0097489 ISO     apical plasma membrane GO:0016324 ISO     integral component of membrane GO:0016021 IEA     intracellular GO:0005622 IDA     nucleus GO:0005634 ISO     plasma membrane GO:0005886 ISO     membrane GO:0016020 ISO     receptor complex GO:0043235 ISO     endoplasmic reticulum GO:0005783 IEA     cytoplasm GO:0005737 ISO