Gene description for Egfr
Gene name epidermal growth factor receptor
Gene symbol Egfr
Other names/aliases 9030024J15Rik
Species Mus musculus
 Database cross references - Egfr
ExoCarta ExoCarta_13649
Entrez Gene 13649
UniProt Q01279  
 Egfr identified in exosomes derived from the following tissue/cell type
Brain cancer cells 19109410    
Mast cells 17486113    
 Gene ontology annotations for Egfr
Molecular Function
    glycoprotein binding GO:0001948 ISO
    transferase activity GO:0016740 IEA
    nitric-oxide synthase regulator activity GO:0030235 ISO
    transmembrane signaling receptor activity GO:0004888 ISO
    signal transducer activity GO:0004871 IDA
    chromatin binding GO:0003682 ISO
    enzyme binding GO:0019899 ISO
    epidermal growth factor-activated receptor activity GO:0005006 ISO
    epidermal growth factor binding GO:0048408 ISO
    actin filament binding GO:0051015 ISO
    nucleotide binding GO:0000166 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    receptor signaling protein tyrosine kinase activity GO:0004716 IEA
    protein binding GO:0005515 IPI
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    ATP binding GO:0005524 IEA
    integrin binding GO:0005178 ISO
    protein tyrosine kinase activity GO:0004713 ISO
    protein phosphatase binding GO:0019903 ISO
    protein kinase binding GO:0019901 ISO
    identical protein binding GO:0042802 ISO
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    kinase activity GO:0016301 IDA
    protein kinase activity GO:0004672 IEA
    receptor binding GO:0005102 ISO
    protein heterodimerization activity GO:0046982 ISO
Biological Process
    positive regulation of protein phosphorylation GO:0001934 ISO
    positive regulation of catenin import into nucleus GO:0035413 ISO
    embryonic placenta development GO:0001892 IMP
    response to calcium ion GO:0051592 ISO
    multicellular organismal development GO:0007275 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 ISO
    cell proliferation GO:0008283 ISO
    positive regulation of protein kinase B signaling GO:0051897 ISO
    positive regulation of vasoconstriction GO:0045907 ISO
    positive regulation of superoxide anion generation GO:0032930 ISO
    negative regulation of mitotic cell cycle GO:0045930 ISO
    cerebral cortex cell migration GO:0021795 IMP
    negative regulation of apoptotic process GO:0043066 ISO
    regulation of cell proliferation GO:0042127 IGI
    activation of MAPKK activity GO:0000186 ISO
    positive regulation of vasodilation GO:0045909 ISO
    positive regulation of MAP kinase activity GO:0043406 ISO
    translation GO:0006412 ISO
    protein phosphorylation GO:0006468 IEA
    learning or memory GO:0007611 ISO
    positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO
    intracellular signal transduction GO:0035556 ISO
    positive regulation of fibroblast proliferation GO:0048146 IMP
    protein autophosphorylation GO:0046777 ISO
    positive regulation of cell migration GO:0030335 ISO
    peptidyl-tyrosine phosphorylation GO:0018108 ISO
    positive regulation of DNA replication GO:0045740 ISO
    response to UV-A GO:0070141 ISO
    morphogenesis of an epithelial fold GO:0060571 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    cellular response to estradiol stimulus GO:0071392 ISO
    positive regulation of smooth muscle cell proliferation GO:0048661 ISO
    neuron projection morphogenesis GO:0048812 ISO
    positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 ISO
    ovulation cycle GO:0042698 ISO
    regulation of nitric-oxide synthase activity GO:0050999 ISO
    positive regulation of phosphorylation GO:0042327 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    hair follicle development GO:0001942 IMP
    positive regulation of epithelial cell proliferation GO:0050679 ISO
    epidermis development GO:0008544 IMP
    signal transduction GO:0007165 ISO
    single organismal cell-cell adhesion GO:0016337 ISO
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 ISO
    magnesium ion homeostasis GO:0010960 ISO
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    positive regulation of inflammatory response GO:0050729 ISO
    astrocyte activation GO:0048143 ISO
    cell surface receptor signaling pathway GO:0007166 ISO
    cell morphogenesis GO:0000902 IGI
    positive regulation of nitric oxide biosynthetic process GO:0045429 ISO
    cellular response to epidermal growth factor stimulus GO:0071364 ISO
    negative regulation of protein catabolic process GO:0042177 ISO
    phosphorylation GO:0016310 IEA
    cellular response to amino acid stimulus GO:0071230 IDA
    digestive tract morphogenesis GO:0048546 IMP
    salivary gland morphogenesis GO:0007435 IMP
    positive regulation of DNA repair GO:0045739 ISO
Subcellular Localization
    membrane raft GO:0045121 ISO
    endosome GO:0005768 ISO
    endosome membrane GO:0010008 ISO
    cell surface GO:0009986 ISO
    endocytic vesicle GO:0030139 ISO
    early endosome membrane GO:0031901 ISO
    basolateral plasma membrane GO:0016323 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    Golgi apparatus GO:0005794 IEA
    focal adhesion GO:0005925 ISO
    multivesicular body, internal vesicle lumen GO:0097489 ISO
    apical plasma membrane GO:0016324 ISO
    integral component of membrane GO:0016021 IEA
    intracellular GO:0005622 IDA
    nucleus GO:0005634 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
    receptor complex GO:0043235 ISO
    endoplasmic reticulum GO:0005783 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Egfr in exosomes
Experiment ID 26
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19109410    
Organism Mus musculus
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD
Journal name FASEB
Publication year 2008
Sample Brain cancer cells
Sample name SMA560vIII
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Egfr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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