Gene description for Jak2
Gene name	Janus kinase 2
Gene symbol	Jak2
Other names/aliases	Fd17
Species	Mus musculus
Database cross references - Jak2
ExoCarta	ExoCarta_16452
Vesiclepedia	VP_16452
Entrez Gene	16452
UniProt	Q62120
Jak2 identified in exosomes derived from the following tissue/cell type
Neural stem cells	25242146
Neural stem cells	25242146

Gene ontology annotations for Jak2

Molecular Function     transferase activity, transferring phosphorus-containing groups GO:0016772 IEA     receptor binding GO:0005102 ISO     growth hormone receptor binding GO:0005131 ISO     ATP binding GO:0005524 IEA     protein tyrosine kinase activity GO:0004713 ISO     histone binding GO:0042393 ISO     interleukin-12 receptor binding GO:0005143 IPI     phosphatidylinositol 3-kinase binding GO:0043548 ISO     heme binding GO:0020037 ISO     kinase activity GO:0016301 IEA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     protein binding GO:0005515 IPI     type 1 angiotensin receptor binding GO:0031702 ISO     nucleotide binding GO:0000166 IEA     insulin receptor substrate binding GO:0043560 ISO     peptide hormone receptor binding GO:0051428 ISO     acetylcholine receptor binding GO:0033130 ISO     protein kinase activity GO:0004672 IEA     transferase activity GO:0016740 IEA     histone kinase activity (H3-Y41 specific) GO:0035401 ISO     protein C-terminus binding GO:0008022 ISO     protein kinase binding GO:0019901 ISO     SH2 domain binding GO:0042169 ISO Biological Process     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     mineralocorticoid receptor signaling pathway GO:0031959 ISO     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IMP     positive regulation of apoptotic process GO:0043065 ISO     innate immune response GO:0045087 IBA     response to granulocyte macrophage colony-stimulating factor GO:0097012 NAS     myeloid cell differentiation GO:0030099 IMP     host programmed cell death induced by symbiont GO:0034050 IDA     G-protein coupled receptor signaling pathway GO:0007186 ISO     growth hormone receptor signaling pathway GO:0060396 ISO     positive regulation of protein import into nucleus, translocation GO:0033160 ISO     interleukin-12-mediated signaling pathway GO:0035722 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     negative regulation of cardiac muscle cell apoptotic process GO:0010667 ISO     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 ISO     positive regulation of DNA binding GO:0043388 ISO     erythrocyte differentiation GO:0030218 IMP     JAK-STAT cascade GO:0007259 ISO     negative regulation of DNA binding GO:0043392 IDA     response to oxidative stress GO:0006979 ISO     hormone-mediated signaling pathway GO:0009755 ISO     positive regulation of growth hormone receptor signaling pathway GO:0060399 IMP     positive regulation of cell activation GO:0050867 ISO     platelet-derived growth factor receptor signaling pathway GO:0048008 ISO     axon regeneration GO:0031103 ISO     phosphorylation GO:0016310 IEA     negative regulation of neuron apoptotic process GO:0043524 ISO     protein phosphorylation GO:0006468 IEA     activation of JAK2 kinase activity GO:0042977 IDA     regulation of cell adhesion GO:0030155 IBA     immune system process GO:0002376 IEA     positive regulation of cell migration GO:0030335 ISO     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IMP     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA     intracellular signal transduction GO:0035556 IDA     negative regulation of cell-cell adhesion GO:0022408 ISO     positive regulation of tumor necrosis factor production GO:0032760 IDA     response to lipopolysaccharide GO:0032496 IDA     negative regulation of heart contraction GO:0045822 ISO     histone H3-Y41 phosphorylation GO:0035409 ISO     signal transduction GO:0007165 IMP     positive regulation of inflammatory response GO:0050729 ISO     enzyme linked receptor protein signaling pathway GO:0007167 IDA     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISO     peptidyl-tyrosine phosphorylation GO:0018108 IDA     response to antibiotic GO:0046677 ISO     positive regulation of interleukin-1 beta production GO:0032731 ISO     regulation of inflammatory response GO:0050727 ISO     positive regulation of cytosolic calcium ion concentration GO:0007204 ISO     cellular response to lipopolysaccharide GO:0071222 IDA     positive regulation of phosphoprotein phosphatase activity GO:0032516 ISO     negative regulation of apoptotic process GO:0043066 IDA     negative regulation of cell proliferation GO:0008285 IMP     mammary gland epithelium development GO:0061180 IMP     chromatin modification GO:0016568 IEA     tyrosine phosphorylation of Stat3 protein GO:0042503 ISO     tyrosine phosphorylation of Stat1 protein GO:0042508 ISO     protein autophosphorylation GO:0046777 ISO     response to tumor necrosis factor GO:0034612 ISO     positive regulation of insulin secretion GO:0032024 ISO     tumor necrosis factor-mediated signaling pathway GO:0033209 ISO     response to interleukin-12 GO:0070671 ISO     STAT protein import into nucleus GO:0007262 IDA     cell differentiation GO:0030154 IMP     cytokine-mediated signaling pathway GO:0019221 TAS     positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 ISO     positive regulation of cell proliferation GO:0008284 ISO     extrinsic apoptotic signaling pathway GO:0097191 IDA     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 IDA     positive regulation of apoptotic signaling pathway GO:2001235 IMP     positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 IDA     cell migration GO:0016477 IBA     cellular response to dexamethasone stimulus GO:0071549 IDA     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 IDA     positive regulation of cell-substrate adhesion GO:0010811 ISO     positive regulation of cell differentiation GO:0045597 ISO     tyrosine phosphorylation of STAT protein GO:0007260 IMP     response to hydroperoxide GO:0033194 ISO     activation of MAPKK activity GO:0000186 ISO     tyrosine phosphorylation of Stat5 protein GO:0042506 ISO     interferon-gamma-mediated signaling pathway GO:0060333 ISO     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI Subcellular Localization     membrane raft GO:0045121 IDA     intracellular GO:0005622 IMP     membrane GO:0016020 IEA     cytoplasm GO:0005737 TAS     nucleus GO:0005634 ISO     caveola GO:0005901 IDA     cytosol GO:0005829 ISO     nuclear matrix GO:0016363 ISO     cytoskeleton GO:0005856 IEA     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA