Gene description for Ptpn1
Gene name	protein tyrosine phosphatase, non-receptor type 1
Gene symbol	Ptpn1
Other names/aliases	PTP-1B PTP-HA2 PTP1B
Species	Mus musculus
Database cross references - Ptpn1
ExoCarta	ExoCarta_19246
Entrez Gene	19246
UniProt	P35821
Ptpn1 identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Ptpn1

Molecular Function     hydrolase activity GO:0016787 IEA     protein kinase binding GO:0019901 ISO     phosphoprotein phosphatase activity GO:0004721 IEA     ephrin receptor binding GO:0046875 ISO     protein phosphatase 2A binding GO:0051721 ISO     phosphatase activity GO:0016791 IEA     receptor tyrosine kinase binding GO:0030971 ISO     protein tyrosine phosphatase activity GO:0004725 ISO     insulin receptor binding GO:0005158 ISO     poly(A) RNA binding GO:0044822 ISO     zinc ion binding GO:0008270 ISO     enzyme binding GO:0019899 ISO Biological Process     positive regulation of protein tyrosine kinase activity GO:0061098 ISO     peptidyl-tyrosine dephosphorylation GO:0035335 ISO     IRE1-mediated unfolded protein response GO:0036498 IMP     negative regulation of ERK1 and ERK2 cascade GO:0070373 IGI     negative regulation of PERK-mediated unfolded protein response GO:1903898 ISO     response to endoplasmic reticulum stress GO:0034976 IMP     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 ISO     regulation of hepatocyte growth factor receptor signaling pathway GO:1902202 ISO     negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IMP     regulation of signal transduction GO:0009966 ISO     endoplasmic reticulum unfolded protein response GO:0030968 ISO     actin cytoskeleton reorganization GO:0031532 ISO     dephosphorylation GO:0016311 IEA     protein dephosphorylation GO:0006470 ISO     activation of JUN kinase activity GO:0007257 IMP     negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IGI     regulation of endocytosis GO:0030100 ISO     regulation of insulin receptor signaling pathway GO:0046626 ISO     negative regulation of MAP kinase activity GO:0043407 ISO     regulation of intracellular protein transport GO:0033157 ISO     insulin receptor signaling pathway GO:0008286 IMP     peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity GO:1990264 IGI     positive regulation of receptor catabolic process GO:2000646 ISO Subcellular Localization     cytoplasmic vesicle GO:0031410 ISO     plasma membrane GO:0005886 ISO     sorting endosome GO:0097443 IDA     endoplasmic reticulum GO:0005783 NAS     early endosome GO:0005769 ISO     membrane GO:0016020 IEA     cytosol GO:0005829 ISO     cytoplasm GO:0005737 IDA     cytoplasmic side of endoplasmic reticulum membrane GO:0098554 ISO