Gene description for EIF2AK2
Gene name	eukaryotic translation initiation factor 2-alpha kinase 2
Gene symbol	EIF2AK2
Other names/aliases	EIF2AK1 PKR PPP1R83 PRKR
Species	Homo sapiens
Database cross references - EIF2AK2
ExoCarta	ExoCarta_5610
Entrez Gene	5610
HGNC	9437
MIM	176871
UniProt	P19525
EIF2AK2 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Thymus	23844026

Gene ontology annotations for EIF2AK2

Molecular Function     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 TAS     non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA     double-stranded RNA binding GO:0003725 IDA     protein kinase activity GO:0004672 IMP     protein binding GO:0005515 IPI     protein serine/threonine kinase activity GO:0004674 TAS     ATP binding GO:0005524 IEA     poly(A) RNA binding GO:0044822 IDA     protein phosphatase type 2A regulator activity GO:0008601 TAS Biological Process     protein autophosphorylation GO:0046777 IMP     innate immune response GO:0045087 IEA     evasion or tolerance by virus of host immune response GO:0030683 TAS     positive regulation of stress-activated MAPK cascade GO:0032874 ISS     negative regulation of osteoblast proliferation GO:0033689 IMP     negative regulation of apoptotic process GO:0043066 IEA     modulation by virus of host morphology or physiology GO:0019048 TAS     positive regulation of chemokine production GO:0032722 ISS     negative regulation of viral genome replication GO:0045071 IMP     defense response to virus GO:0051607 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IEA     response to interferon-alpha GO:0035455 IDA     regulation of hematopoietic progenitor cell differentiation GO:1901532 ISS     translation GO:0006412 IEA     transcription, DNA-templated GO:0006351 IEA     positive regulation of cytokine production GO:0001819 ISS     negative regulation of translation GO:0017148 IMP     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     positive regulation of NIK/NF-kappaB signaling GO:1901224 ISS     negative regulation of cell proliferation GO:0008285 TAS     protein phosphorylation GO:0006468 IDA     regulation of translational initiation by eIF2 alpha phosphorylation GO:0010998 TAS     modulation by virus of host process GO:0019054 TAS     response to virus GO:0009615 IMP     endoplasmic reticulum unfolded protein response GO:0030968 IEA     regulation of hematopoietic stem cell differentiation GO:1902036 ISS     regulation of NLRP3 inflammasome complex assembly GO:1900225 ISS     activation of MAPKK activity GO:0000186 IMP     viral life cycle GO:0019058 TAS     regulation of protein phosphatase type 2A activity GO:0034047 TAS     regulation of hematopoietic stem cell proliferation GO:1902033 ISS Subcellular Localization     membrane GO:0016020 IDA     perinuclear region of cytoplasm GO:0048471 IDA     ribosome GO:0005840 TAS     nucleus GO:0005634 IEA     cytosol GO:0005829 TAS     cytoplasm GO:0005737 IDA