Gene description for FAS
Gene name	Fas cell surface death receptor
Gene symbol	FAS
Other names/aliases	ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6
Species	Homo sapiens
Database cross references - FAS
ExoCarta	ExoCarta_355
Entrez Gene	355
HGNC	11920
MIM	134637
UniProt	P25445
FAS identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for FAS

Molecular Function     signal transducer activity GO:0004871 TAS     receptor activity GO:0004872 NAS     identical protein binding GO:0042802 IPI     transmembrane signaling receptor activity GO:0004888 IEA     kinase binding GO:0019900 IPI     protein binding GO:0005515 IPI Biological Process     regulation of necrotic cell death GO:0010939 TAS     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IEA     negative thymic T cell selection GO:0045060 IEA     regulation of myeloid cell differentiation GO:0045637 IEA     positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IEA     regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 TAS     renal system process GO:0003014 IEA     negative regulation of B cell activation GO:0050869 IEA     signal transduction GO:0007165 TAS     B cell mediated immunity GO:0019724 IEA     inflammatory cell apoptotic process GO:0006925 IEA     immunoglobulin production GO:0002377 IEA     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 TAS     response to toxic substance GO:0009636 IEA     positive regulation of protein homooligomerization GO:0032464 IEA     cellular response to mechanical stimulus GO:0071260 IEP     hepatocyte apoptotic process GO:0097284 IEA     activation-induced cell death of T cells GO:0006924 IEA     regulation of apoptotic process GO:0042981 NAS     protein homooligomerization GO:0051260 IEA     spleen development GO:0048536 IEA     necroptotic process GO:0070266 TAS     circadian rhythm GO:0007623 IEA     cell surface receptor signaling pathway GO:0007166 TAS     apoptotic process GO:0006915 TAS     apoptotic signaling pathway GO:0097190 TAS     transformed cell apoptotic process GO:0006927 IEA     cellular response to lithium ion GO:0071285 IEA     protein complex assembly GO:0006461 TAS     programmed cell death GO:0012501 TAS     cellular response to hyperoxia GO:0071455 IMP     motor neuron apoptotic process GO:0097049 IEA     necroptotic signaling pathway GO:0097527 IMP     programmed necrotic cell death GO:0097300 TAS     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 TAS     positive regulation of apoptotic process GO:0043065 IMP     extrinsic apoptotic signaling pathway GO:0097191 TAS     regulation of lymphocyte differentiation GO:0045619 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 TAS     negative regulation of apoptotic process GO:0043066 TAS     response to glucocorticoid GO:0051384 IEA Subcellular Localization     extracellular exosome GO:0070062 IDA     cytosol GO:0005829 NAS     membrane raft GO:0045121 IDA     cell surface GO:0009986 IDA     death-inducing signaling complex GO:0031264 IDA     nucleus GO:0005634 IDA     plasma membrane GO:0005886 TAS     integral component of membrane GO:0016021 IEA     cytoplasm GO:0005737 IDA     external side of plasma membrane GO:0009897 IEA     CD95 death-inducing signaling complex GO:0031265 IDA