Gene description for SRPR
Gene name signal recognition particle receptor (docking protein)
Gene symbol SRPR
Other names/aliases DP
Sralpha
Species Homo sapiens
 Database cross references - SRPR
ExoCarta ExoCarta_6734
Entrez Gene 6734
HGNC 11307
MIM 182180
UniProt P08240  
 SRPR identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for SRPR
Molecular Function
    GTPase activity GO:0003924 IEA
    signal recognition particle binding GO:0005047 IEA
    poly(A) RNA binding GO:0044822 IDA
    GTP binding GO:0005525 IEA
Biological Process
    gene expression GO:0010467 TAS
    translation GO:0006412 TAS
    SRP-dependent cotranslational protein targeting to membrane GO:0006614 TAS
    IRE1-mediated unfolded protein response GO:0036498 TAS
    cotranslational protein targeting to membrane GO:0006613 TAS
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    cellular protein metabolic process GO:0044267 TAS
Subcellular Localization
    integral component of membrane GO:0016021 TAS
    endoplasmic reticulum GO:0005783 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 IDA
    signal recognition particle receptor complex GO:0005785 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SRPR in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for SRPR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SSR2  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SRPR is involved
PathwayEvidenceSource
SRP-dependent cotranslational protein targeting to membrane TAS Reactome
XBP1(S) activates chaperone genes TAS Reactome





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