Gene description for MAP3K4
Gene name mitogen-activated protein kinase kinase kinase 4
Gene symbol MAP3K4
Other names/aliases MAPKKK4
MEKK 4
MEKK4
MTK1
PRO0412
Species Homo sapiens
 Database cross references - MAP3K4
ExoCarta ExoCarta_4216
Vesiclepedia VP_4216
Entrez Gene 4216
HGNC 6856
MIM 602425
UniProt Q9Y6R4  
 MAP3K4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MAP3K4
Molecular Function
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    MAP kinase kinase activity GO:0004708 IBA
    MAP kinase kinase kinase activity GO:0004709 IDA
Biological Process
    positive regulation of p38MAPK cascade GO:1900745 IDA
    MAPK cascade GO:0000165 IEA
    regulation of gene expression GO:0010468 IEA
    placenta development GO:0001890 IEA
    positive regulation of JUN kinase activity GO:0043507 IDA
    male germ-line sex determination GO:0019100 IEA
    activation of MAPK activity GO:0000187 IBA
    chorionic trophoblast cell differentiation GO:0060718 IEA
    activation of MAPKK activity GO:0000186 IDA
    response to UV-C GO:0010225 IMP
    intracellular signal transduction GO:0035556 ISS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IEA
    intracellular GO:0005622 IBA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified MAP3K4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MAP3K4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GADD45G  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 GADD45A  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 CDC42 998
Reconstituted Complex Homo sapiens
4 MAP2K6 5608
Invitro Homo sapiens
Invivo Homo sapiens
5 MAP2K3 5606
Invitro Homo sapiens
Invivo Homo sapiens
6 RAC1 5879
Reconstituted Complex Homo sapiens
7 GADD45B  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
8 MAPK13 5603
Invitro Homo sapiens
Invivo Homo sapiens
9 MAP2K4 6416
Invitro Homo sapiens
Invivo Homo sapiens
10 MAP2K1 5604
Invitro Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which MAP3K4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here