Gene description for ALK
Gene name anaplastic lymphoma receptor tyrosine kinase
Gene symbol ALK
Other names/aliases CD246
Species Homo sapiens
 Database cross references - ALK
ExoCarta ExoCarta_238
Entrez Gene 238
HGNC 427
MIM 105590
UniProt Q9UM73  
 ALK identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ALK
Molecular Function
    transmembrane receptor protein tyrosine kinase activity GO:0004714 TAS
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    protein tyrosine kinase activity GO:0004713 IDA
    ATP binding GO:0005524 IEA
    NF-kappaB-inducing kinase activity GO:0004704 TAS
Biological Process
    regulation of apoptotic process GO:0042981 TAS
    cell proliferation GO:0008283 TAS
    activation of MAPK activity GO:0000187 TAS
    protein autophosphorylation GO:0046777 TAS
    neuron development GO:0048666 TAS
    signal transduction GO:0007165 TAS
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    NIK/NF-kappaB signaling GO:0038061 TAS
    phosphorylation GO:0016310 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 TAS
Subcellular Localization
    protein complex GO:0043234 IDA
    integral component of plasma membrane GO:0005887 TAS
    extracellular exosome GO:0070062 IDA
    intracellular GO:0005622 TAS
 Experiment description of studies that identified ALK in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ALK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RASA1 5921
Invivo Homo sapiens
2 PTN  
Reconstituted Complex Homo sapiens
3 JAK3 3718
Affinity Capture-Western Homo sapiens
4 SHC3  
Affinity Capture-Western Homo sapiens
5 PLCG1 5335
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
6 IRS1 3667
Invivo Homo sapiens
7 SHC1 6464
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ALK is involved
No pathways found

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