Gene description for IRS1
Gene name	insulin receptor substrate 1
Gene symbol	IRS1
Other names/aliases	HIRS-1
Species	Homo sapiens
Database cross references - IRS1
ExoCarta	ExoCarta_3667
Entrez Gene	3667
HGNC	6125
MIM	147545
UniProt	P35568
IRS1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for IRS1

Molecular Function     signal transducer activity GO:0004871 IEA     phosphatidylinositol 3-kinase binding GO:0043548 ISS     SH2 domain binding GO:0042169 ISS     protein kinase C binding GO:0005080 ISS     protein binding GO:0005515 IPI     insulin receptor binding GO:0005158 IPI     insulin-like growth factor receptor binding GO:0005159 IPI     transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 ISS Biological Process     positive regulation of cell proliferation GO:0008284 NAS     response to insulin GO:0032868 IDA     protein localization to nucleus GO:0034504 IEA     lipid catabolic process GO:0016042 IEA     positive regulation of glucose import GO:0046326 IMP     Fc-epsilon receptor signaling pathway GO:0038095 TAS     positive regulation of glycogen biosynthetic process GO:0045725 NAS     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     positive regulation of cell migration GO:0030335 IEA     negative regulation of insulin secretion GO:0046676 IDA     protein kinase B signaling GO:0043491 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     positive regulation of glucose metabolic process GO:0010907 IMP     regulation of gene expression GO:0010468 IEA     positive regulation of fatty acid beta-oxidation GO:0032000 IMP     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     mammary gland development GO:0030879 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS     negative regulation of insulin receptor signaling pathway GO:0046627 ISS     response to peptide hormone GO:0043434 ISS     positive regulation of mesenchymal cell proliferation GO:0002053 IEA     insulin-like growth factor receptor signaling pathway GO:0048009 IPI     cellular response to insulin stimulus GO:0032869 IMP     insulin receptor signaling pathway GO:0008286 TAS     phosphatidylinositol 3-kinase signaling GO:0014065 IDA     signal transduction GO:0007165 TAS     positive regulation of glucose import in response to insulin stimulus GO:2001275 IDA     glucose homeostasis GO:0042593 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISS     positive regulation of insulin receptor signaling pathway GO:0046628 ISS     innate immune response GO:0045087 TAS Subcellular Localization     plasma membrane GO:0005886 TAS     ciliary basal body GO:0036064 IEA     cytosol GO:0005829 TAS     insulin receptor complex GO:0005899 ISS     caveola GO:0005901 IDA     cytoplasm GO:0005737 ISS     nucleus GO:0005634 ISS     intracellular membrane-bounded organelle GO:0043231 ISS