Gene description for LRPAP1
Gene name low density lipoprotein receptor-related protein associated protein 1
Gene symbol LRPAP1
Other names/aliases A2MRAP
A2RAP
HBP44
MRAP
MYP23
RAP
alpha-2-MRAP
Species Homo sapiens
 Database cross references - LRPAP1
ExoCarta ExoCarta_4043
Vesiclepedia VP_4043
Entrez Gene 4043
HGNC 6701
MIM 104225
UniProt P30533  
 LRPAP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRPAP1
Molecular Function
    amyloid-beta binding GO:0001540 TAS
    signaling receptor binding GO:0005102 TAS
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
    lipase binding GO:0035473 IBA
    receptor ligand activity GO:0048018 IDA
    receptor antagonist activity GO:0048019 IBA
    receptor antagonist activity GO:0048019 IDA
    receptor antagonist activity GO:0048019 TAS
    low-density lipoprotein particle receptor binding GO:0050750 IBA
    low-density lipoprotein particle receptor binding GO:0050750 IDA
    low-density lipoprotein particle receptor binding GO:0050750 TAS
    very-low-density lipoprotein particle receptor binding GO:0070326 IBA
    very-low-density lipoprotein particle receptor binding GO:0070326 IPI
Biological Process
    negative regulation of receptor internalization GO:0002091 IBA
    negative regulation of receptor internalization GO:0002091 IGI
    signal transduction GO:0007165 IDA
    negative regulation of very-low-density lipoprotein particle clearance GO:0010916 IBA
    negative regulation of very-low-density lipoprotein particle clearance GO:0010916 IDA
    negative regulation of protein binding GO:0032091 IDA
    regulation of receptor-mediated endocytosis GO:0048259 IDA
    amyloid-beta clearance by transcytosis GO:0150093 IMP
    extracellular negative regulation of signal transduction GO:1900116 TAS
    negative regulation of amyloid-beta clearance GO:1900222 IGI
    positive regulation of amyloid-beta clearance GO:1900223 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    endosome GO:0005768 IBA
    endosome GO:0005768 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IBA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    Golgi apparatus GO:0005794 IDA
    Golgi lumen GO:0005796 IEA
    cis-Golgi network GO:0005801 IBA
    cis-Golgi network GO:0005801 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    cell surface GO:0009986 IEA
    endomembrane system GO:0012505 IBA
    endosome lumen GO:0031904 IEA
    rough endoplasmic reticulum lumen GO:0048237 IBA
    rough endoplasmic reticulum lumen GO:0048237 IDA
 Experiment description of studies that identified LRPAP1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRPAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 SORL1 6653
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
4 PRPF38B 55119
Affinity Capture-MS Homo sapiens
5 PPIL4  
Affinity Capture-MS Homo sapiens
6 TARDBP 23435
Co-fractionation Homo sapiens
7 PRPF38A 84950
Affinity Capture-MS Homo sapiens
8 GMIP  
Affinity Capture-MS Homo sapiens
9 EPB41L5 57669
Affinity Capture-MS Homo sapiens
10 UBA1 7317
Co-fractionation Homo sapiens
11 NOP56 10528
Proximity Label-MS Homo sapiens
12 MFAP4 4239
Affinity Capture-MS Homo sapiens
13 ROCK2 9475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PRPF3  
Affinity Capture-MS Homo sapiens
15 LRRC59 55379
Proximity Label-MS Homo sapiens
16 SYDE2  
Affinity Capture-MS Homo sapiens
17 RTN4 57142
Two-hybrid Homo sapiens
18 TCEB3 6924
Affinity Capture-MS Homo sapiens
19 MEIS2  
Affinity Capture-MS Homo sapiens
20 GPATCH4 54865
Affinity Capture-MS Homo sapiens
21 HOXA5  
Affinity Capture-MS Homo sapiens
22 RAF1 5894
Two-hybrid Homo sapiens
23 BTN3A1 11119
Affinity Capture-MS Homo sapiens
24 AP2A1 160
Co-fractionation Homo sapiens
25 MAT2B 27430
Co-fractionation Homo sapiens
26 CPSF7 79869
Affinity Capture-MS Homo sapiens
27 PDIA6 10130
Affinity Capture-MS Homo sapiens
28 NUSAP1 51203
Affinity Capture-MS Homo sapiens
29 CANX 821
Affinity Capture-MS Homo sapiens
30 GTSE1 51512
Affinity Capture-MS Homo sapiens
31 MECP2 4204
Affinity Capture-MS Homo sapiens
32 TACO1  
Affinity Capture-MS Homo sapiens
33 FAM20C 56975
Affinity Capture-MS Homo sapiens
34 MSH2 4436
Co-fractionation Homo sapiens
35 RALGDS  
Two-hybrid Homo sapiens
36 Arhgap1 228359
Affinity Capture-MS Mus musculus
37 PXMP2  
Proximity Label-MS Homo sapiens
38 LCOR 84458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CALR3  
Proximity Label-MS Homo sapiens
40 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
41 RPS19 6223
Affinity Capture-MS Homo sapiens
42 MEPCE 56257
Affinity Capture-MS Homo sapiens
43 NUP50 10762
Co-fractionation Homo sapiens
44 IL1R2  
Affinity Capture-MS Homo sapiens
45 MICU2 221154
Affinity Capture-MS Homo sapiens
46 POLA2  
Two-hybrid Homo sapiens
47 TPD52 7163
Co-fractionation Homo sapiens
48 MAPT  
Co-fractionation Homo sapiens
49 IDS  
Affinity Capture-MS Homo sapiens
50 CYB5A 1528
Co-fractionation Homo sapiens
51 GTF2H1 2965
Affinity Capture-MS Homo sapiens
52 SDF2L1 23753
Affinity Capture-MS Homo sapiens
53 JADE2 23338
Affinity Capture-MS Homo sapiens
54 DNAJB9 4189
Proximity Label-MS Homo sapiens
55 NSRP1  
Affinity Capture-MS Homo sapiens
56 LYAR 55646
Affinity Capture-MS Homo sapiens
57 RRP1B 23076
Affinity Capture-MS Homo sapiens
58 EIF4EBP1  
Affinity Capture-Western Homo sapiens
59 LRP1B 53353
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 PAK2 5062
Co-fractionation Homo sapiens
61 SEC61B 10952
Proximity Label-MS Homo sapiens
62 SRPK1 6732
Affinity Capture-MS Homo sapiens
63 CCNT1  
Affinity Capture-MS Homo sapiens
64 SP100 6672
Affinity Capture-MS Homo sapiens
65 COX4I1 1327
Proximity Label-MS Homo sapiens
66 PID1 55022
Affinity Capture-MS Homo sapiens
67 ARSA 410
Affinity Capture-MS Homo sapiens
68 VLDLR 7436
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 DNAJB14  
Proximity Label-MS Homo sapiens
70 HSPA5 3309
Proximity Label-MS Homo sapiens
71 FAM76B  
Affinity Capture-MS Homo sapiens
72 EFNA4  
Affinity Capture-MS Homo sapiens
73 PRPF4B 8899
Affinity Capture-MS Homo sapiens
74 C10orf107  
Affinity Capture-MS Homo sapiens
75 LRP4 4038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 DNAJB12 54788
Proximity Label-MS Homo sapiens
77 TP53BP1 7158
Affinity Capture-MS Homo sapiens
78 POP1 10940
Affinity Capture-MS Homo sapiens
79 MRPS11  
Affinity Capture-MS Homo sapiens
80 BCAP31 10134
Proximity Label-MS Homo sapiens
81 CUL3 8452
Affinity Capture-MS Homo sapiens
82 CTTN 2017
Affinity Capture-MS Homo sapiens
83 DCPS 28960
Co-fractionation Homo sapiens
84 TOX4  
Affinity Capture-MS Homo sapiens
85 YY1 7528
Affinity Capture-MS Homo sapiens
86 ANKRD36B  
Affinity Capture-MS Homo sapiens
87 SLTM 79811
Affinity Capture-MS Homo sapiens
88 SART1 9092
Affinity Capture-MS Homo sapiens
89 Ect2  
Affinity Capture-MS Mus musculus
90 G6PD 2539
Co-fractionation Homo sapiens
91 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
92 LUC7L2 51631
Affinity Capture-MS Homo sapiens
93 DNAJC18  
Proximity Label-MS Homo sapiens
94 CSNK1D 1453
Affinity Capture-MS Homo sapiens
95 MFAP1  
Affinity Capture-MS Homo sapiens
96 PSPC1 55269
Affinity Capture-MS Homo sapiens
97 SEC31A 22872
Co-fractionation Homo sapiens
98 PHF6  
Affinity Capture-MS Homo sapiens
99 MTOR 2475
Affinity Capture-Western Homo sapiens
100 TOP1 7150
Affinity Capture-MS Homo sapiens
101 ASPH 444
Two-hybrid Homo sapiens
102 FIP1L1 81608
Affinity Capture-MS Homo sapiens
103 DNAJC10 54431
Proximity Label-MS Homo sapiens
104 PPP1R10  
Affinity Capture-MS Homo sapiens
105 DNAJC3 5611
Proximity Label-MS Homo sapiens
106 CSNK1E 1454
Affinity Capture-MS Homo sapiens
107 AKAP1 8165
Proximity Label-MS Homo sapiens
108 NUDT21 11051
Affinity Capture-MS Homo sapiens
109 GLUD1 2746
Affinity Capture-MS Homo sapiens
110 TTC5  
Co-fractionation Homo sapiens
111 CPSF6 11052
Affinity Capture-MS Homo sapiens
112 AP2M1 1173
Co-fractionation Homo sapiens
113 RPS21 6227
Affinity Capture-MS Homo sapiens
114 C9orf114  
Affinity Capture-MS Homo sapiens
115 PDIA4 9601
Proximity Label-MS Homo sapiens
116 ETV7  
Two-hybrid Homo sapiens
117 CALU 813
Proximity Label-MS Homo sapiens
118 SF3B4 10262
Affinity Capture-MS Homo sapiens
119 NUFIP2 57532
Affinity Capture-MS Homo sapiens
120 RBM25 58517
Affinity Capture-MS Homo sapiens
121 CUL5 8065
Co-fractionation Homo sapiens
122 LRP1 4035
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
123 NGEF  
Affinity Capture-MS Homo sapiens
124 KNOP1 400506
Affinity Capture-MS Homo sapiens
125 C1orf35  
Affinity Capture-MS Homo sapiens
126 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
127 TAF2  
Affinity Capture-MS Homo sapiens
128 EPB41L2 2037
Affinity Capture-MS Homo sapiens
129 DDX58 23586
Affinity Capture-RNA Homo sapiens
130 PPM1H  
Co-fractionation Homo sapiens
131 TMA16  
Affinity Capture-MS Homo sapiens
132 HNRNPL 3191
Co-fractionation Homo sapiens
133 SORT1 6272
Reconstituted Complex Homo sapiens
134 LRP2 4036
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
135 DNAJB11 51726
Proximity Label-MS Homo sapiens
136 CD4 920
Affinity Capture-MS Homo sapiens
137 DDX42 11325
Affinity Capture-MS Homo sapiens
138 LDLR 3949
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 EIF5A 1984
Affinity Capture-MS Homo sapiens
140 CKAP4 10970
Affinity Capture-MS Homo sapiens
141 IRS1 3667
Co-fractionation Homo sapiens
142 DDX56  
Affinity Capture-MS Homo sapiens
143 RANBP2 5903
Two-hybrid Homo sapiens
144 LRP8 7804
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
145 DNAJC30  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRPAP1 is involved
No pathways found





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