Gene description for PID1
Gene name phosphotyrosine interaction domain containing 1
Gene symbol PID1
Other names/aliases HMFN2073
NYGGF4
P-CLI1
PCLI1
Species Homo sapiens
 Database cross references - PID1
ExoCarta ExoCarta_55022
Vesiclepedia VP_55022
Entrez Gene 55022
HGNC 26084
MIM 612930
UniProt Q7Z2X4  
 PID1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PID1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of protein phosphorylation GO:0001933 IDA
    energy reserve metabolic process GO:0006112 IC
    mitochondrion organization GO:0007005 IMP
    positive regulation of gene expression GO:0010628 IMP
    regulation of mitochondrial fusion GO:0010635 IC
    cellular response to leptin stimulus GO:0044320 IEA
    fat cell differentiation GO:0045444 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    negative regulation of D-glucose import GO:0046325 IBA
    negative regulation of D-glucose import GO:0046325 IDA
    negative regulation of insulin receptor signaling pathway GO:0046627 IDA
    regulation of mitochondrial membrane potential GO:0051881 ISS
    regulation of mitochondrial membrane potential GO:0051881 TAS
    positive regulation of fat cell proliferation GO:0070346 IDA
    cellular response to cytokine stimulus GO:0071345 ISS
    cellular response to interleukin-6 GO:0071354 ISS
    cellular response to tumor necrosis factor GO:0071356 ISS
    cellular response to tumor necrosis factor GO:0071356 NAS
    cellular response to fatty acid GO:0071398 ISS
    negative regulation of protein localization to plasma membrane GO:1903077 IDA
    regulation of reactive oxygen species metabolic process GO:2000377 IBA
    regulation of reactive oxygen species metabolic process GO:2000377 ISS
    positive regulation of reactive oxygen species metabolic process GO:2000379 IMP
    negative regulation of ATP biosynthetic process GO:2001170 IMP
    positive regulation of ATP biosynthetic process GO:2001171 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PID1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PID1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-1  
Two-hybrid Homo sapiens
2 NOTCH2NL 388677
Two-hybrid Homo sapiens
3 LRP4 4038
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 ADAMTSL4  
Two-hybrid Homo sapiens
5 SPERT  
Two-hybrid Homo sapiens
6 BANP  
Two-hybrid Homo sapiens
7 MDFI  
Two-hybrid Homo sapiens
8 EGFR 1956
Affinity Capture-MS Homo sapiens
9 Cubn  
Affinity Capture-MS Mus musculus
10 RIPK4  
Affinity Capture-MS Homo sapiens
11 Lrp1 16971
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
12 THAP1  
Two-hybrid Homo sapiens
13 CRX  
Two-hybrid Homo sapiens
14 GOLGA2 2801
Two-hybrid Homo sapiens
15 LRP1 4035
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
16 LRPAP1 4043
Affinity Capture-MS Homo sapiens
17 NME1 4830
Two-hybrid Homo sapiens
18 CUBN 8029
Affinity Capture-Western Homo sapiens
19 PRC1 9055
Affinity Capture-MS Homo sapiens
20 CPSF7 79869
Two-hybrid Homo sapiens
21 SCRN3 79634
Affinity Capture-MS Homo sapiens
22 CCDC33 80125
Two-hybrid Homo sapiens
23 GOPC 57120
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PID1 is involved
No pathways found





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