Gene description for CUBN
Gene name	cubilin (intrinsic factor-cobalamin receptor)
Gene symbol	CUBN
Other names/aliases	IFCR MGA1 gp280
Species	Homo sapiens
Database cross references - CUBN
ExoCarta	ExoCarta_8029
Vesiclepedia	VP_8029
Entrez Gene	8029
HGNC	2548
MIM	602997
UniProt	O60494
CUBN identified in exosomes derived from the following tissue/cell type
Urine	15326289
Urine	19056867
Urine	21082674
Urine	25452312

Gene ontology annotations for CUBN

Molecular Function     calcium ion binding GO:0005509 IEA     protein homodimerization activity GO:0042803 IDA     receptor activity GO:0004872 IEA     transporter activity GO:0005215 TAS     protein binding GO:0005515 IPI     cobalamin binding GO:0031419 IEA Biological Process     cobalamin metabolic process GO:0009235 TAS     small molecule metabolic process GO:0044281 TAS     tissue homeostasis GO:0001894 NAS     steroid metabolic process GO:0008202 TAS     vitamin metabolic process GO:0006766 TAS     vitamin D metabolic process GO:0042359 TAS     water-soluble vitamin metabolic process GO:0006767 TAS     cholesterol metabolic process GO:0008203 IEA     lipoprotein metabolic process GO:0042157 TAS     receptor-mediated endocytosis GO:0006898 NAS     lipoprotein transport GO:0042953 IEA     cobalamin transport GO:0015889 TAS Subcellular Localization     lysosomal lumen GO:0043202 TAS     endoplasmic reticulum GO:0005783 IEA     Golgi apparatus GO:0005794 IEA     endosome membrane GO:0010008 TAS     extracellular exosome GO:0070062 IDA     coated pit GO:0005905 IEA     extrinsic component of external side of plasma membrane GO:0031232 NAS     endocytic vesicle GO:0030139 IDA     brush border membrane GO:0031526 NAS     apical plasma membrane GO:0016324 IDA     cytosol GO:0005829 TAS     lysosomal membrane GO:0005765 IEA     membrane GO:0016020 TAS     plasma membrane GO:0005886 TAS