Gene description for BRCA1
Gene name	breast cancer 1, early onset
Gene symbol	BRCA1
Other names/aliases	BRCAI BRCC1 BROVCA1 FANCS IRIS PNCA4 PPP1R53 PSCP RNF53
Species	Homo sapiens
Database cross references - BRCA1
ExoCarta	ExoCarta_672
Entrez Gene	672
HGNC	1100
MIM	113705
UniProt	P38398
BRCA1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for BRCA1

Molecular Function     ubiquitin protein ligase binding GO:0031625 IPI     protein binding GO:0005515 IPI     RNA binding GO:0003723 IDA     DNA binding GO:0003677 TAS     ubiquitin-protein transferase activity GO:0004842 IDA     transcription coactivator activity GO:0003713 NAS     transcription regulatory region DNA binding GO:0044212 IDA     zinc ion binding GO:0008270 IEA     damaged DNA binding GO:0003684 IEA     tubulin binding GO:0015631 NAS     enzyme binding GO:0019899 IPI     androgen receptor binding GO:0050681 NAS     ligase activity GO:0016874 IEA Biological Process     negative regulation of fatty acid biosynthetic process GO:0045717 IMP     regulation of DNA methylation GO:0044030 IEA     positive regulation of histone H3-K9 acetylation GO:2000617 IDA     regulation of cell proliferation GO:0042127 TAS     androgen receptor signaling pathway GO:0030521 NAS     positive regulation of transcription, DNA-templated GO:0045893 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     protein sumoylation GO:0016925 TAS     negative regulation of reactive oxygen species metabolic process GO:2000378 IMP     regulation of transcription from RNA polymerase III promoter GO:0006359 TAS     protein ubiquitination GO:0016567 IDA     protein autoubiquitination GO:0051865 IDA     positive regulation of cell cycle arrest GO:0071158 IDA     response to ionizing radiation GO:0010212 IMP     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IDA     DNA repair GO:0006281 TAS     centrosome cycle GO:0007098 IEA     regulation of gene expression by genetic imprinting GO:0006349 IEA     double-strand break repair via homologous recombination GO:0000724 TAS     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IMP     negative regulation of centriole replication GO:0046600 NAS     positive regulation of histone H3-K4 methylation GO:0051571 IDA     cellular response to tumor necrosis factor GO:0071356 IMP     protein K6-linked ubiquitination GO:0085020 IDA     cellular response to indole-3-methanol GO:0071681 IDA     cellular response to DNA damage stimulus GO:0006974 TAS     positive regulation of histone acetylation GO:0035066 IDA     negative regulation of histone acetylation GO:0035067 IBA     chordate embryonic development GO:0043009 IBA     positive regulation of protein ubiquitination GO:0031398 IDA     double-strand break repair GO:0006302 TAS     chromosome segregation GO:0007059 IMP     dosage compensation by inactivation of X chromosome GO:0009048 IBA     apoptotic process GO:0006915 TAS     regulation of transcription from RNA polymerase II promoter GO:0006357 TAS     G2 DNA damage checkpoint GO:0031572 IMP     positive regulation of histone H4-K20 methylation GO:0070512 IDA     positive regulation of angiogenesis GO:0045766 IMP     cellular protein metabolic process GO:0044267 TAS     positive regulation of histone H4-K16 acetylation GO:2000620 IDA     regulation of apoptotic process GO:0042981 TAS     positive regulation of gene expression GO:0010628 IMP     postreplication repair GO:0006301 IDA     DNA replication GO:0006260 IEA     negative regulation of histone H3-K9 methylation GO:0051573 IDA     negative regulation of histone H3-K4 methylation GO:0051572 IEA     DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 TAS     positive regulation of vascular endothelial growth factor production GO:0010575 IMP     post-translational protein modification GO:0043687 TAS     positive regulation of DNA repair GO:0045739 IMP     positive regulation of histone H3-K9 methylation GO:0051574 IEA     response to estrogen GO:0043627 IDA     fatty acid biosynthetic process GO:0006633 IEA     negative regulation of transcription, DNA-templated GO:0045892 IDA Subcellular Localization     BRCA1-BARD1 complex GO:0031436 IDA     plasma membrane GO:0005886 IDA     cytoplasm GO:0005737 IDA     gamma-tubulin ring complex GO:0008274 NAS     chromosome GO:0005694 ISS     nucleoplasm GO:0005654 TAS     protein complex GO:0043234 IDA     nucleus GO:0005634 IDA     BRCA1-A complex GO:0070531 IDA     ubiquitin ligase complex GO:0000151 NAS     ribonucleoprotein complex GO:0030529 IDA     condensed nuclear chromosome GO:0000794 IEA