Gene description for GNL3L
Gene name guanine nucleotide binding protein-like 3 (nucleolar)-like
Gene symbol GNL3L
Other names/aliases -
Species Homo sapiens
 Database cross references - GNL3L
ExoCarta ExoCarta_54552
Vesiclepedia VP_54552
Entrez Gene 54552
HGNC 25553
MIM 300873
UniProt Q9NVN8  
 GNL3L identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GNL3L
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
Biological Process
    positive regulation of protein-containing complex assembly GO:0031334 IMP
    negative regulation of protein ubiquitination GO:0031397 IMP
    regulation of protein stability GO:0031647 IDA
    regulation of protein stability GO:0031647 IMP
    negative regulation of protein binding GO:0032091 IDA
    negative regulation of telomere maintenance via telomerase GO:0032211 IMP
    negative regulation of protein sumoylation GO:0033234 IMP
    ribosome biogenesis GO:0042254 IEA
    positive regulation of protein localization to chromosome, telomeric region GO:1904816 IDA
    positive regulation of protein localization to chromosome, telomeric region GO:1904816 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    telomerase holoenzyme complex GO:0005697 IDA
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified GNL3L in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GNL3L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGOLN2 10618
Affinity Capture-MS Homo sapiens
2 ROPN1  
Two-hybrid Homo sapiens
3 UBE2H 7328
Affinity Capture-MS Homo sapiens
4 SMC3 9126
Affinity Capture-MS Homo sapiens
5 PPP1CB 5500
Cross-Linking-MS (XL-MS) Homo sapiens
6 SPRTN  
Affinity Capture-MS Homo sapiens
7 NOP58 51602
Co-fractionation Homo sapiens
8 KPNA1 3836
Two-hybrid Homo sapiens
9 S100A6 6277
Affinity Capture-MS Homo sapiens
10 BBS7 55212
Affinity Capture-MS Homo sapiens
11 TMED5 50999
Cross-Linking-MS (XL-MS) Homo sapiens
12 TRIM66  
Affinity Capture-MS Homo sapiens
13 BRCA1 672
Affinity Capture-MS Homo sapiens
14 RPL10 6134
Affinity Capture-MS Homo sapiens
15 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SRP72 6731
Co-fractionation Homo sapiens
17 TRIM54  
Two-hybrid Homo sapiens
18 APEX1 328
Proximity Label-MS Homo sapiens
19 OLA1 29789
Co-fractionation Homo sapiens
20 RAMP2  
Affinity Capture-MS Homo sapiens
21 FAM174A 345757
Affinity Capture-MS Homo sapiens
22 MAGEA9  
Affinity Capture-MS Homo sapiens
23 TFIP11  
Two-hybrid Homo sapiens
24 MTUS2 23281
Two-hybrid Homo sapiens
25 Ncstn 59287
Affinity Capture-MS Mus musculus
26 DGCR2 9993
Affinity Capture-MS Homo sapiens
27 TERT  
Affinity Capture-Western Homo sapiens
28 MYCN  
Affinity Capture-MS Homo sapiens
29 FTSJ1 24140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RPS11 6205
Cross-Linking-MS (XL-MS) Homo sapiens
31 KIF14 9928
Affinity Capture-MS Homo sapiens
32 PES1 23481
Co-fractionation Homo sapiens
33 BSG 682
Affinity Capture-MS Homo sapiens
34 ALAS1  
Two-hybrid Homo sapiens
35 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 CTBP1 1487
Two-hybrid Homo sapiens
37 GOLGA2 2801
Two-hybrid Homo sapiens
38 PROZ 8858
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 Srp72  
Affinity Capture-MS Mus musculus
40 RPL31 6160
Proximity Label-MS Homo sapiens
41 GPR182  
Affinity Capture-MS Homo sapiens
42 EXOSC5 56915
Affinity Capture-MS Homo sapiens
43 ADRB2  
PCA Homo sapiens
44 PRKAR1B  
Two-hybrid Homo sapiens
45 GTPBP4 23560
Co-fractionation Homo sapiens
46 NOP56 10528
Proximity Label-MS Homo sapiens
47 CD3EAP  
Proximity Label-MS Homo sapiens
48 NT5E 4907
Affinity Capture-MS Homo sapiens
49 ZBTB2 57621
Affinity Capture-MS Homo sapiens
50 SV2A 9900
Affinity Capture-MS Homo sapiens
51 S100P 6286
Affinity Capture-MS Homo sapiens
52 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SLC2A4  
Affinity Capture-MS Homo sapiens
54 EIF6 3692
Proximity Label-MS Homo sapiens
55 PTH2R  
Affinity Capture-MS Homo sapiens
56 OTULIN 90268
Affinity Capture-MS Homo sapiens
57 CMKLR1 1240
Affinity Capture-MS Homo sapiens
58 BRD8 10902
Affinity Capture-MS Homo sapiens
59 MGARP  
Affinity Capture-MS Homo sapiens
60 PRSS50  
Affinity Capture-MS Homo sapiens
61 CUL3 8452
Affinity Capture-MS Homo sapiens
62 Rrbp1  
Affinity Capture-MS Mus musculus
63 EGFR 1956
Negative Genetic Homo sapiens
64 HMBOX1  
Two-hybrid Homo sapiens
65 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
66 ERP44 23071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 LZTS2 84445
Two-hybrid Homo sapiens
68 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
69 RPA3 6119
Proximity Label-MS Homo sapiens
70 ATP2A1 487
Affinity Capture-MS Homo sapiens
71 RPL27A 6157
Affinity Capture-MS Homo sapiens
72 NMD3 51068
Co-fractionation Homo sapiens
73 DDRGK1 65992
Affinity Capture-MS Homo sapiens
74 RHOB 388
Proximity Label-MS Homo sapiens
75 Rpl35 66489
Affinity Capture-MS Mus musculus
76 FTSJ3 117246
Co-fractionation Homo sapiens
77 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
78 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
79 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
80 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
81 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
82 OLFM4 10562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 MKI67  
Affinity Capture-MS Homo sapiens
84 NIFK 84365
Proximity Label-MS Homo sapiens
85 TERF1 7013
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
86 RPS24 6229
Proximity Label-MS Homo sapiens
87 RPS6 6194
Proximity Label-MS Homo sapiens
88 BRD1 23774
Affinity Capture-MS Homo sapiens
89 LDOC1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
90 SERBP1 26135
Proximity Label-MS Homo sapiens
91 KRAS 3845
Negative Genetic Homo sapiens
92 HNRNPU 3192
Affinity Capture-MS Homo sapiens
93 C9orf72  
Affinity Capture-MS Homo sapiens
94 NUDT14 256281
Affinity Capture-MS Homo sapiens
95 HSF2BP  
Two-hybrid Homo sapiens
96 ZNF467  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GNL3L is involved
No pathways found





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