Gene description for Ncstn
Gene name nicastrin
Gene symbol Ncstn
Other names/aliases 9430068N19Rik
AA727311
Aph2
D1Dau13e
Kiaa0253
Nct
mKIAA0253
Species Mus musculus
 Database cross references - Ncstn
ExoCarta ExoCarta_59287
Entrez Gene 59287
UniProt P57716  
 Ncstn identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Ncstn
Molecular Function
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 ISO
    endopeptidase activity GO:0004175 IMP
Biological Process
    protein processing GO:0016485 ISO
    positive regulation of catalytic activity GO:0043085 ISO
    beta-amyloid metabolic process GO:0050435 IMP
    Notch signaling pathway GO:0007219 IEA
    proteolysis GO:0006508 IMP
    epithelial cell proliferation GO:0050673 IMP
    membrane protein ectodomain proteolysis GO:0006509 ISO
    myeloid cell homeostasis GO:0002262 IMP
    T cell proliferation GO:0042098 IMP
Subcellular Localization
    lysosomal membrane GO:0005765 ISO
    membrane GO:0016020 ISO
    Golgi apparatus GO:0005794 ISO
    focal adhesion GO:0005925 ISO
    integral component of plasma membrane GO:0005887 ISO
    endoplasmic reticulum GO:0005783 ISO
    extracellular exosome GO:0070062 ISO
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Ncstn in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ncstn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here