Gene description for ERLEC1
Gene name endoplasmic reticulum lectin 1
Gene symbol ERLEC1
Other names/aliases C2orf30
CIM
CL24936
CL25084
HEL117
XTP3-B
XTP3TPB
Species Homo sapiens
 Database cross references - ERLEC1
ExoCarta ExoCarta_27248
Vesiclepedia VP_27248
Entrez Gene 27248
HGNC 25222
MIM 611229
UniProt Q96DZ1  
 ERLEC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ERLEC1
Molecular Function
    protein binding GO:0005515 IDA
    protein binding GO:0005515 IPI
    unfolded protein binding GO:0051082 IDA
Biological Process
    endoplasmic reticulum unfolded protein response GO:0030968 IEA
    retrograde protein transport, ER to cytosol GO:0030970 IBA
    ERAD pathway GO:0036503 IDA
    ERAD pathway GO:0036503 TAS
    negative regulation of retrograde protein transport, ER to cytosol GO:1904153 IMP
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IBA
    endoplasmic reticulum lumen GO:0005788 IDA
    endoplasmic reticulum quality control compartment GO:0044322 TAS
 Experiment description of studies that identified ERLEC1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ERLEC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPATS2  
Affinity Capture-MS Homo sapiens
2 UTP14A 10813
Affinity Capture-MS Homo sapiens
3 CNTNAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 DERL2 51009
Affinity Capture-MS Homo sapiens
5 FKBP7 51661
Affinity Capture-MS Homo sapiens
6 CALML3 810
Affinity Capture-MS Homo sapiens
7 KLK5 25818
Affinity Capture-MS Homo sapiens
8 ASGR2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 PLD4  
Affinity Capture-MS Homo sapiens
10 ZC3H4 23211
Affinity Capture-MS Homo sapiens
11 MYO5C 55930
Affinity Capture-MS Homo sapiens
12 SEMA4A  
Affinity Capture-MS Homo sapiens
13 MRPL52  
Co-fractionation Homo sapiens
14 SYVN1 84447
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
15 PPP1R10  
Affinity Capture-MS Homo sapiens
16 FBXO34  
Affinity Capture-MS Homo sapiens
17 UBE2G2  
Affinity Capture-MS Homo sapiens
18 SAFB 6294
Affinity Capture-MS Homo sapiens
19 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
20 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SCARA3  
Affinity Capture-MS Homo sapiens
22 SPECC1L 23384
Affinity Capture-MS Homo sapiens
23 MYO5B 4645
Affinity Capture-MS Homo sapiens
24 FAM8A1 51439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
25 TRIOBP 11078
Affinity Capture-MS Homo sapiens
26 YES1 7525
Affinity Capture-MS Homo sapiens
27 CDK12 51755
Affinity Capture-MS Homo sapiens
28 RAI14 26064
Affinity Capture-MS Homo sapiens
29 SEL1L 6400
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
30 CLEC2B  
Affinity Capture-MS Homo sapiens
31 Ncstn 59287
Affinity Capture-MS Mus musculus
32 LIPG 9388
Affinity Capture-MS Homo sapiens
33 SMPD1 6609
Affinity Capture-MS Homo sapiens
34 SERPINA1 5265
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 CGA  
Affinity Capture-MS Homo sapiens
36 FAM20C 56975
Affinity Capture-MS Homo sapiens
37 MICA 100507436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SFSWAP  
Affinity Capture-MS Homo sapiens
39 ATP1B4  
Affinity Capture-MS Homo sapiens
40 ST3GAL1 6482
Affinity Capture-MS Homo sapiens
41 ALDH1A2 8854
Affinity Capture-MS Homo sapiens
42 IGH 3492
Affinity Capture-MS Homo sapiens
43 HSP90B1 7184
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
44 TMOD1  
Affinity Capture-MS Homo sapiens
45 CPVL 54504
Affinity Capture-MS Homo sapiens
46 C12orf49  
Affinity Capture-MS Homo sapiens
47 LMO7 4008
Affinity Capture-MS Homo sapiens
48 GDF11 10220
Affinity Capture-MS Homo sapiens
49 EMILIN3  
Affinity Capture-MS Homo sapiens
50 C4BPB 725
Affinity Capture-MS Homo sapiens
51 B4GALT3 8703
Affinity Capture-MS Homo sapiens
52 ARHGEF12 23365
Affinity Capture-MS Homo sapiens
53 PTPRO 5800
Affinity Capture-MS Homo sapiens
54 LRCH3 84859
Affinity Capture-MS Homo sapiens
55 NYX  
Affinity Capture-MS Homo sapiens
56 FBXL4 26235
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 LIMA1 51474
Affinity Capture-MS Homo sapiens
58 RBBP6 5930
Affinity Capture-MS Homo sapiens
59 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
60 PIGT 51604
Co-fractionation Homo sapiens
61 ATF6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 MRPL24  
Co-fractionation Homo sapiens
63 DOCK7 85440
Affinity Capture-MS Homo sapiens
64 CHST8 64377
Affinity Capture-MS Homo sapiens
65 B3GNT3 10331
Affinity Capture-MS Homo sapiens
66 TJP1 7082
Affinity Capture-MS Homo sapiens
67 PRPF40A 55660
Affinity Capture-MS Homo sapiens
68 CLN5  
Affinity Capture-MS Homo sapiens
69 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 SLTM 79811
Affinity Capture-MS Homo sapiens
71 TCIRG1 10312
Co-fractionation Homo sapiens
72 MYO1D 4642
Affinity Capture-MS Homo sapiens
73 CREB3  
Affinity Capture-MS Homo sapiens
74 MARCH4  
Affinity Capture-MS Homo sapiens
75 ASIC4  
Affinity Capture-MS Homo sapiens
76 GXYLT1 283464
Affinity Capture-MS Homo sapiens
77 CGN  
Affinity Capture-MS Homo sapiens
78 CST9L  
Affinity Capture-MS Homo sapiens
79 MPRIP 23164
Affinity Capture-MS Homo sapiens
80 UBE2J1 51465
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
81 DDX46 9879
Affinity Capture-MS Homo sapiens
82 PPT1 5538
Affinity Capture-MS Homo sapiens
83 PRKCSH 5589
Co-fractionation Homo sapiens
84 NAAA  
Affinity Capture-MS Homo sapiens
85 PRRC2A 7916
Affinity Capture-MS Homo sapiens
86 BCAS2 10286
Affinity Capture-MS Homo sapiens
87 DIDO1  
Affinity Capture-MS Homo sapiens
88 SVIL 6840
Affinity Capture-MS Homo sapiens
89 FOXRED2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 MISP 126353
Affinity Capture-MS Homo sapiens
91 CLEC2D  
Affinity Capture-MS Homo sapiens
92 PRRC2C 23215
Affinity Capture-MS Homo sapiens
93 EDEM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 OS9 10956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
95 DDX58 23586
Affinity Capture-RNA Homo sapiens
96 ATF6B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 PLD3 23646
Affinity Capture-MS Homo sapiens
98 SLC27A3 11000
Affinity Capture-MS Homo sapiens
99 TPST2 8459
Affinity Capture-MS Homo sapiens
100 Sel1l  
Affinity Capture-MS Mus musculus
101 PEX5 5830
Affinity Capture-MS Homo sapiens
102 CUEDC1 404093
Affinity Capture-MS Homo sapiens
103 PLD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
104 TRAV20  
Affinity Capture-MS Homo sapiens
105 CDC5L 988
Affinity Capture-MS Homo sapiens
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