Gene description for BCAS2
Gene name breast carcinoma amplified sequence 2
Gene symbol BCAS2
Other names/aliases DAM1
SPF27
Snt309
Species Homo sapiens
 Database cross references - BCAS2
ExoCarta ExoCarta_10286
Vesiclepedia VP_10286
Entrez Gene 10286
HGNC 975
MIM 605783
UniProt O75934  
 BCAS2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for BCAS2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    RNA splicing, via transesterification reactions GO:0000375 TAS
    alternative mRNA splicing, via spliceosome GO:0000380 IEA
    mRNA splicing, via spliceosome GO:0000398 IDA
    mRNA splicing, via spliceosome GO:0000398 NAS
    ovarian follicle development GO:0001541 IEA
    RNA splicing GO:0008380 TAS
    protein catabolic process GO:0030163 IEA
    oocyte development GO:0048599 IEA
    spindle assembly GO:0051225 IEA
Subcellular Localization
    Prp19 complex GO:0000974 IBA
    Prp19 complex GO:0000974 IPI
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    DNA replication factor A complex GO:0005662 IDA
    spliceosomal complex GO:0005681 IDA
    spliceosomal complex GO:0005681 IPI
    nucleolus GO:0005730 IEA
    centrosome GO:0005813 IDA
    nuclear speck GO:0016607 IDA
    U2-type catalytic step 2 spliceosome GO:0071007 IDA
    catalytic step 2 spliceosome GO:0071013 IBA
 Experiment description of studies that identified BCAS2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BCAS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCDC12  
Affinity Capture-MS Homo sapiens
2 RNGTT 8732
Affinity Capture-MS Homo sapiens
3 GCFC2  
Affinity Capture-MS Homo sapiens
4 Mrpl13  
Two-hybrid Mus musculus
5 CCDC94  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 Smek1  
Affinity Capture-MS Mus musculus
7 Pef1  
Two-hybrid Mus musculus
8 DGCR14  
Affinity Capture-MS Homo sapiens
9 SNRPE 6635
Affinity Capture-MS Homo sapiens
10 BAG2 9532
Affinity Capture-MS Homo sapiens
11 Prpf8 192159
Affinity Capture-MS Mus musculus
12 FAM167A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 RBM22 55696
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
14 PCF11 51585
Co-fractionation Homo sapiens
15 PRPF8 10594
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
16 PPIE 10450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TADA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RPA2 6118
Affinity Capture-MS Homo sapiens
19 QKI 9444
Two-hybrid Homo sapiens
20 CTNNBL1 56259
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
21 MIIP 60672
Two-hybrid Homo sapiens
22 Ccdc12  
Affinity Capture-MS Mus musculus
23 KRT37 8688
Two-hybrid Homo sapiens
24 UBC 7316
Reconstituted Complex Homo sapiens
25 LAMP2 3920
Co-fractionation Homo sapiens
26 PRPF3  
Co-fractionation Homo sapiens
27 TFPI 7035
Co-fractionation Homo sapiens
28 AAR2 25980
Affinity Capture-MS Homo sapiens
29 AQR 9716
Affinity Capture-MS Homo sapiens
30 SYF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 UNKL  
Affinity Capture-MS Homo sapiens
32 SNRPF 6636
Affinity Capture-MS Homo sapiens
33 SOX2  
Affinity Capture-MS Homo sapiens
34 DUT 1854
Two-hybrid Homo sapiens
35 USB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LMO2  
Two-hybrid Homo sapiens
37 EIF4ENIF1 56478
Two-hybrid Homo sapiens
38 DDX23 9416
Co-fractionation Homo sapiens
39 C11orf30  
Affinity Capture-MS Homo sapiens
40 GPATCH1  
Affinity Capture-MS Homo sapiens
41 KIF23 9493
Affinity Capture-MS Homo sapiens
42 TRNAU1AP  
Two-hybrid Homo sapiens
43 Snw1  
Affinity Capture-MS Mus musculus
44 ISY1 57461
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 WDR83  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
46 FBXW7  
Affinity Capture-MS Homo sapiens
47 KRT40  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
48 HGS 9146
Two-hybrid Homo sapiens
49 CPSF7 79869
Two-hybrid Homo sapiens
50 NPM1 4869
Affinity Capture-MS Homo sapiens
51 SRRM2 23524
Affinity Capture-MS Homo sapiens
52 SNRPC 6631
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
53 Nsa2 59050
Two-hybrid Mus musculus
54 OIP5  
Two-hybrid Homo sapiens
55 OBSL1 23363
Affinity Capture-MS Homo sapiens
56 SF3A2 8175
Affinity Capture-MS Homo sapiens
57 RBPMS 11030
Two-hybrid Homo sapiens
58 KRT31 3881
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
59 PRRC2B  
Two-hybrid Homo sapiens
60 Ssbp1  
Two-hybrid Mus musculus
61 USHBP1  
Two-hybrid Homo sapiens
62 ZBTB8B  
Affinity Capture-MS Homo sapiens
63 C9orf24  
Two-hybrid Homo sapiens
64 FAM86C1  
Two-hybrid Homo sapiens
65 EED  
Affinity Capture-MS Homo sapiens
66 U2AF1 7307
Co-fractionation Homo sapiens
67 POT1  
Two-hybrid Homo sapiens
68 PRCC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 MECP2 4204
Affinity Capture-MS Homo sapiens
70 FHIT 2272
Two-hybrid Homo sapiens
71 CUL1 8454
Affinity Capture-MS Homo sapiens
72 MYCN  
Affinity Capture-MS Homo sapiens
73 BUD31 8896
Affinity Capture-MS Homo sapiens
74 NCSTN 23385
Co-fractionation Homo sapiens
75 LMO4  
Two-hybrid Homo sapiens
76 HSPA8 3312
Co-fractionation Homo sapiens
77 LIN28A  
Affinity Capture-MS Homo sapiens
78 DHX35  
Affinity Capture-MS Homo sapiens
79 CNOT4 4850
Two-hybrid Homo sapiens
80 KRT34  
Two-hybrid Homo sapiens
81 HNRNPA0 10949
Co-fractionation Homo sapiens
82 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
83 MYOZ3  
Two-hybrid Homo sapiens
84 ZMAT5  
Two-hybrid Homo sapiens
85 PPIL1 51645
Affinity Capture-MS Homo sapiens
86 TP53BP2  
Two-hybrid Homo sapiens
87 RPS10 6204
Co-fractionation Homo sapiens
88 Nudt21 68219
Two-hybrid Mus musculus
89 RBM4B  
Affinity Capture-MS Homo sapiens
90 Crnkl1  
Affinity Capture-MS Mus musculus
91 PNN 5411
Affinity Capture-MS Homo sapiens
92 RPL5 6125
Two-hybrid Homo sapiens
93 ACIN1 22985
Co-fractionation Homo sapiens
94 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
95 KRTAP8-1  
Two-hybrid Homo sapiens
96 KRT35 3886
Two-hybrid Homo sapiens
97 SNRNP200 23020
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
98 PFDN5 5204
Two-hybrid Homo sapiens
99 GCC2 9648
Affinity Capture-MS Homo sapiens
100 CCDC120  
Two-hybrid Homo sapiens
101 Ctnnbl1  
Affinity Capture-MS Mus musculus
102 SNRPD1 6632
Co-fractionation Homo sapiens
103 EMILIN3  
Two-hybrid Homo sapiens
104 IFI16 3428
Affinity Capture-MS Homo sapiens
105 U2AF2 11338
Affinity Capture-Western Homo sapiens
106 SNRPB2 6629
Affinity Capture-MS Homo sapiens
107 SNRPN 6638
Affinity Capture-MS Homo sapiens
108 SF3B6 51639
Co-fractionation Homo sapiens
109 SLAIN1 122060
Two-hybrid Homo sapiens
110 HECTD1 25831
Affinity Capture-MS Homo sapiens
111 MAGOH 4116
Affinity Capture-MS Homo sapiens
112 CYLD  
Affinity Capture-MS Homo sapiens
113 DSN1 79980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 DHX8 1659
Affinity Capture-MS Homo sapiens
115 FGFBP1 9982
Affinity Capture-MS Homo sapiens
116 DISC1 27185
Affinity Capture-MS Homo sapiens
117 Bbs5  
Two-hybrid Mus musculus
118 CWF19L1 55280
Affinity Capture-MS Homo sapiens
119 RBM39 9584
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
120 PCP4  
Affinity Capture-MS Homo sapiens
121 PRPF4B 8899
Affinity Capture-MS Homo sapiens
122 UBE2H 7328
Affinity Capture-MS Homo sapiens
123 ERLEC1 27248
Affinity Capture-MS Homo sapiens
124 KDM4D  
Affinity Capture-MS Homo sapiens
125 LMNB1 4001
Affinity Capture-MS Homo sapiens
126 RC3H2  
Affinity Capture-MS Homo sapiens
127 IKZF3  
Two-hybrid Homo sapiens
128 PLEKHF2 79666
Two-hybrid Homo sapiens
129 SNRPB 6628
Affinity Capture-MS Homo sapiens
130 TCHP  
Two-hybrid Homo sapiens
131 PLRG1 5356
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
132 2700060E02Rik 68045
Two-hybrid Mus musculus
133 KRT75 9119
Two-hybrid Homo sapiens
134 ZWINT  
Two-hybrid Homo sapiens
135 Rbm14  
Two-hybrid Mus musculus
136 TRIO 7204
Co-fractionation Homo sapiens
137 SF1 7536
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
138 XAB2 56949
Affinity Capture-MS Homo sapiens
139 METTL23  
Affinity Capture-MS Homo sapiens
140 DNAJC17  
Proximity Label-MS Homo sapiens
141 C10orf82  
Two-hybrid Homo sapiens
142 TSSC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 RABGAP1 23637
Affinity Capture-MS Homo sapiens
144 SNX27 81609
Affinity Capture-MS Homo sapiens
145 SUZ12  
Affinity Capture-MS Homo sapiens
146 NIP7 51388
Two-hybrid Homo sapiens
147 KRT27 342574
Two-hybrid Homo sapiens
148 NXF1 10482
Affinity Capture-RNA Homo sapiens
149 SF3A1 10291
Affinity Capture-MS Homo sapiens
150 RBM6 10180
Affinity Capture-MS Homo sapiens
151 EFTUD2 9343
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
152 PAX5  
Two-hybrid Homo sapiens
153 MKRN1 23608
Affinity Capture-MS Homo sapiens
154 Tsnax  
Two-hybrid Mus musculus
155 PRPF19 27339
Far Western Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
156 MYC  
Affinity Capture-MS Homo sapiens
157 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
158 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
159 LINS  
Affinity Capture-MS Homo sapiens
160 TOP1 7150
Affinity Capture-MS Homo sapiens
161 NHP2L1 4809
Co-fractionation Homo sapiens
162 SRSF10 10772
Co-fractionation Homo sapiens
163 PPP1R32  
Two-hybrid Homo sapiens
164 DDRGK1 65992
Affinity Capture-MS Homo sapiens
165 RNF2  
Affinity Capture-MS Homo sapiens
166 SF3B3 23450
Co-fractionation Homo sapiens
167 ACY1 95
Two-hybrid Homo sapiens
168 TFIP11  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
169 BRD3 8019
Affinity Capture-MS Homo sapiens
170 KRT222 125113
Affinity Capture-MS Homo sapiens
171 LARP4 113251
Two-hybrid Homo sapiens
172 CRNKL1 51340
Affinity Capture-MS Homo sapiens
173 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
174 PPP4C 5531
Affinity Capture-MS Homo sapiens
175 PCBD2 84105
Two-hybrid Homo sapiens
176 SF3B1 23451
Affinity Capture-MS Homo sapiens
177 KRT36 8689
Two-hybrid Homo sapiens
178 CPSF6 11052
Affinity Capture-MS Homo sapiens
179 Cdc5l 71702
Affinity Capture-MS Mus musculus
180 PLAGL2  
Two-hybrid Homo sapiens
181 INPPL1 3636
Affinity Capture-MS Homo sapiens
182 MCM5 4174
Co-fractionation Homo sapiens
183 SF3B4 10262
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
184 USP36  
Affinity Capture-MS Homo sapiens
185 ENKD1  
Two-hybrid Homo sapiens
186 RPA1 6117
Affinity Capture-MS Homo sapiens
187 DMRTB1  
Two-hybrid Homo sapiens
188 SNRPA 6626
Affinity Capture-MS Homo sapiens
189 CCDC130  
Affinity Capture-MS Homo sapiens
190 ZDBF2  
Affinity Capture-MS Homo sapiens
191 DCTN2 10540
Proximity Label-MS Homo sapiens
192 CDC40  
Affinity Capture-MS Homo sapiens
193 CWF19L2  
Affinity Capture-MS Homo sapiens
194 EIF4A3 9775
Affinity Capture-MS Homo sapiens
195 EPB41L2 2037
Affinity Capture-MS Homo sapiens
196 CWC15  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
197 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
198 UFL1 23376
Affinity Capture-MS Homo sapiens
199 SNRNP40 9410
Affinity Capture-MS Homo sapiens
200 MBNL1 4154
Two-hybrid Homo sapiens
201 ECM1 1893
Two-hybrid Homo sapiens
202 TCF4  
Two-hybrid Homo sapiens
203 KRT20 54474
Two-hybrid Homo sapiens
204 KRTAP19-6  
Two-hybrid Homo sapiens
205 HNRNPLL 92906
Two-hybrid Homo sapiens
206 AIMP2 7965
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
207 CIT 11113
Affinity Capture-MS Homo sapiens
208 ANKHD1 54882
Two-hybrid Homo sapiens
209 NDEL1 81565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 Flot1 14251