Gene description for ISY1
Gene name ISY1 splicing factor homolog (S. cerevisiae)
Gene symbol ISY1
Other names/aliases FSAP33
Species Homo sapiens
 Database cross references - ISY1
ExoCarta ExoCarta_57461
Vesiclepedia VP_57461
Entrez Gene 57461
HGNC 29201
MIM 612764
UniProt Q9ULR0  
 ISY1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ISY1
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    generation of catalytic spliceosome for second transesterification step GO:0000350 IBA
    mRNA 3'-splice site recognition GO:0000389 IBA
    mRNA splicing, via spliceosome GO:0000398 IC
    mRNA splicing, via spliceosome GO:0000398 IDA
Subcellular Localization
    Prp19 complex GO:0000974 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    U2-type catalytic step 1 spliceosome GO:0071006 IDA
    catalytic step 2 spliceosome GO:0071013 IBA
    catalytic step 2 spliceosome GO:0071013 IDA
    post-mRNA release spliceosomal complex GO:0071014 IBA
    post-spliceosomal complex GO:0071020 IBA
 Experiment description of studies that identified ISY1 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ISY1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 PSMA6 5687
Co-fractionation Homo sapiens
3 NUPL2 11097
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 RALYL 138046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 HNRNPC 3183
Affinity Capture-MS Homo sapiens
7 REC8  
Affinity Capture-MS Homo sapiens
8 DGCR14  
Affinity Capture-MS Homo sapiens
9 SNRPG 6637
Affinity Capture-MS Homo sapiens
10 SNRPE 6635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RBM22 55696
Affinity Capture-MS Homo sapiens
12 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
13 PPIE 10450
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ACOT9 23597
Affinity Capture-MS Homo sapiens
15 ACTC1 70
Proximity Label-MS Homo sapiens
16 CTNNBL1 56259
Affinity Capture-MS Homo sapiens
17 DHX8 1659
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
18 Ccdc12  
Affinity Capture-MS Mus musculus
19 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
20 DVL3 1857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CCDC94  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SYF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ILF2 3608
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
26 USB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 AQR 9716
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 LMO2  
Two-hybrid Homo sapiens
29 CPSF2 53981
Co-fractionation Homo sapiens
30 CRNKL1 51340
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
31 GPATCH1  
Affinity Capture-MS Homo sapiens
32 Snw1  
Affinity Capture-MS Mus musculus
33 ISY1 57461
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 WDR83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SNRPC 6631
Affinity Capture-MS Homo sapiens
36 TFIP11  
Affinity Capture-MS Homo sapiens
37 SF3A2 8175
Co-fractionation Homo sapiens
38 SNRPD3 6634
Affinity Capture-MS Homo sapiens
39 ATG16L1 55054
Affinity Capture-MS Homo sapiens
40 MECP2 4204
Affinity Capture-MS Homo sapiens
41 BUD31 8896
Co-fractionation Homo sapiens
42 Bcas2  
Affinity Capture-MS Mus musculus
43 PRPF8 10594
Co-fractionation Homo sapiens
44 LIN28B  
Affinity Capture-MS Homo sapiens
45 PPIL1 51645
Affinity Capture-MS Homo sapiens
46 TRA2A 29896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 Crnkl1  
Affinity Capture-MS Mus musculus
48 MAPRE1 22919
Affinity Capture-MS Homo sapiens
49 SRSF6 6431
Affinity Capture-MS Homo sapiens
50 UBE2I 7329
Affinity Capture-MS Homo sapiens
51 SNRPB 6628
Affinity Capture-MS Homo sapiens
52 RCCD1  
Affinity Capture-MS Homo sapiens
53 LUC7L2 51631
Affinity Capture-MS Homo sapiens
54 SNRPN 6638
Affinity Capture-MS Homo sapiens
55 SF3A3 10946
Co-fractionation Homo sapiens
56 CCDC12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CWF19L1 55280
Affinity Capture-MS Homo sapiens
59 RBM39 9584
Affinity Capture-MS Homo sapiens
60 PRPF4B 8899
Affinity Capture-MS Homo sapiens
61 C11orf57  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 CCNC  
Two-hybrid Homo sapiens
63 SGOL1  
Affinity Capture-MS Homo sapiens
64 LMNB1 4001
Affinity Capture-MS Homo sapiens
65 DHX35  
Affinity Capture-MS Homo sapiens
66 PNN 5411
Affinity Capture-MS Homo sapiens
67 CD2BP2 10421
Affinity Capture-MS Homo sapiens
68 PLRG1 5356
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
69 ACAD11 84129
Affinity Capture-MS Homo sapiens
70 XAB2 56949
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
71 DNAJC17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 FAM90A1  
Two-hybrid Homo sapiens
73 TSSC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ZC3H11A  
Affinity Capture-MS Homo sapiens
75 SUZ12  
Affinity Capture-MS Homo sapiens
76 GCFC2  
Affinity Capture-MS Homo sapiens
77 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
78 NXF1 10482
Affinity Capture-RNA Homo sapiens
79 SF3A1 10291
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
80 EFTUD2 9343
Affinity Capture-MS Homo sapiens
81 KIAA1143  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 PRPF19 27339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
83 ZC3H18  
Affinity Capture-MS Homo sapiens
84 PABPC5 140886
Affinity Capture-MS Homo sapiens
85 TOP1 7150
Affinity Capture-MS Homo sapiens
86 WSB2 55884
Affinity Capture-MS Homo sapiens
87 KDM8  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
88 SF3B3 23450
Co-fractionation Homo sapiens
89 BRD3 8019
Affinity Capture-MS Homo sapiens
90 POLE4  
Co-fractionation Homo sapiens
91 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
92 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 EAPP  
Affinity Capture-MS Homo sapiens
94 BCAS2 10286
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 SRRM1 10250
Affinity Capture-MS Homo sapiens
96 EXOC8 149371
Two-hybrid Homo sapiens
97 CDC40  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
98 SSRP1 6749
Affinity Capture-MS Homo sapiens
99 SAP18 10284
Affinity Capture-MS Homo sapiens
100 SNRPA 6626
Affinity Capture-MS Homo sapiens
101 CWF19L2  
Affinity Capture-MS Homo sapiens
102 CHD4 1108
Affinity Capture-MS Homo sapiens
103 SHMT2 6472
Affinity Capture-RNA Homo sapiens
104 PTBP2  
Two-hybrid Homo sapiens
105 DDX58 23586
Affinity Capture-RNA Homo sapiens
106 CWC15  
Affinity Capture-MS Homo sapiens
107 SNRNP40 9410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 SNIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 MOV10 4343
Affinity Capture-RNA Homo sapiens
110 ZCCHC10  
Affinity Capture-MS Homo sapiens
111 SNW1 22938
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 KRAS 3845
Negative Genetic Homo sapiens
113 CD44 960
Affinity Capture-MS Homo sapiens
114 LMO1  
Two-hybrid Homo sapiens
115 SNRPA1 6627
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
116 CPSF6 11052
Affinity Capture-MS Homo sapiens
117 CPSF3 51692
Co-fractionation Homo sapiens
118 ZNF830  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 CDC5L 988
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
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