Gene description for WSB2
Gene name WD repeat and SOCS box containing 2
Gene symbol WSB2
Other names/aliases SBA2
Species Homo sapiens
 Database cross references - WSB2
ExoCarta ExoCarta_55884
Vesiclepedia VP_55884
Entrez Gene 55884
HGNC 19222
UniProt Q9NYS7  
 WSB2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for WSB2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein polyubiquitination GO:0000209 IBA
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified WSB2 in exosomes
1
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for WSB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCLAF1 9774
Affinity Capture-MS Homo sapiens
2 ARIH2 10425
Affinity Capture-MS Homo sapiens
3 IL21R  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 AMBRA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PNN 5411
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZC3H14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CUL5 8065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
9 CCDC9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
11 C17orf85  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RNF7  
Affinity Capture-MS Homo sapiens
13 ACIN1 22985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EZH2  
Two-hybrid Homo sapiens
16 SNIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PFDN2 5202
Affinity Capture-MS Homo sapiens
18 RNPS1 10921
Affinity Capture-MS Homo sapiens
19 BCL2L1 598
Affinity Capture-MS Homo sapiens
20 SREBF2 6721
Positive Genetic Homo sapiens
21 SUPT6H 6830
Affinity Capture-MS Homo sapiens
22 DDA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ISY1 57461
Affinity Capture-MS Homo sapiens
24 CLASRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TCEB2 6923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DDB1 1642
Affinity Capture-Western Homo sapiens
27 CSF3R  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
PCA Homo sapiens
28 NKTR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 AKAP1 8165
Proximity Label-MS Homo sapiens
30 CUL4A 8451
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which WSB2 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





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