Gene description for BCL2L1
Gene name BCL2-like 1
Gene symbol BCL2L1
Other names/aliases BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
Species Homo sapiens
 Database cross references - BCL2L1
ExoCarta ExoCarta_598
Vesiclepedia VP_598
Entrez Gene 598
HGNC 992
MIM 600039
UniProt Q07817  
 BCL2L1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BCL2L1
Molecular Function
    protein homodimerization activity GO:0042803 IBA
    BH3 domain binding GO:0051434 IPI
    protein kinase binding GO:0019901 IPI
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IBA
Biological Process
    apoptotic process in bone marrow GO:0071839 IEA
    release of cytochrome c from mitochondria GO:0001836 IDA
    growth GO:0040007 IEA
    negative regulation of anoikis GO:2000811 IMP
    cellular response to gamma radiation GO:0071480 IEA
    cellular process regulating host cell cycle in response to virus GO:0060154 IEA
    innate immune response GO:0045087 TAS
    suppression by virus of host apoptotic process GO:0019050 IDA
    regulation of mitochondrial membrane permeability GO:0046902 IDA
    response to cycloheximide GO:0046898 IEA
    regulation of mitochondrial membrane potential GO:0051881 IDA
    ovarian follicle development GO:0001541 IEA
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS
    cytokinesis GO:0000910 IMP
    negative regulation of autophagy GO:0010507 TAS
    mitochondrion morphogenesis GO:0070584 IEA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IDA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 TAS
    intrinsic apoptotic signaling pathway GO:0097193 TAS
    in utero embryonic development GO:0001701 IEA
    hepatocyte apoptotic process GO:0097284 IEA
    negative regulation of apoptotic process GO:0043066 IMP
    apoptotic process GO:0006915 TAS
    neuron apoptotic process GO:0051402 IEA
    negative regulation of release of cytochrome c from mitochondria GO:0090201 IDA
    fertilization GO:0009566 IEA
    mitotic cell cycle checkpoint GO:0007093 IMP
    negative regulation of neuron apoptotic process GO:0043524 IEA
    spermatogenesis GO:0007283 IEA
    cell proliferation GO:0008283 IEA
    apoptotic mitochondrial changes GO:0008637 TAS
    germ cell development GO:0007281 IEA
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 TAS
    male gonad development GO:0008584 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IBA
    response to cytokine GO:0034097 IDA
    programmed cell death GO:0012501 TAS
    positive regulation of cell proliferation GO:0008284 IEA
    extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IBA
    negative regulation of establishment of protein localization to plasma membrane GO:0090005 IDA
    cellular response to alkaloid GO:0071312 IEA
    cellular response to amino acid stimulus GO:0071230 IEA
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 IDA
    endocytosis GO:0006897 IEA
    negative regulation of execution phase of apoptosis GO:1900118 IDA
Subcellular Localization
    mitochondrial matrix GO:0005759 IEA
    integral component of membrane GO:0016021 IEA
    cell junction GO:0030054 IEA
    mitochondrial inner membrane GO:0005743 IEA
    Bcl-2 family protein complex GO:0097136 IDA
    centrosome GO:0005813 IDA
    nuclear membrane GO:0031965 IEA
    nucleus GO:0005634 IDA
    synaptic vesicle membrane GO:0030672 IEA
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IEA
    cytoplasm GO:0005737 IDA
    mitochondrial outer membrane GO:0005741 TAS
 Experiment description of studies that identified BCL2L1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BCL2L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BBC3  
Affinity Capture-Western Homo sapiens
2 APAF1 317
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 AVEN 57099
Invivo Homo sapiens
Two-hybrid Homo sapiens
4 BNIP3 664
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
5 PSEN1 5663
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 BAX 581
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
7 BAD  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
8 TP53 7157
Affinity Capture-MS Homo sapiens
9 BID  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
10 MOAP1  
Affinity Capture-MS Homo sapiens
11 PPP1CA 5499
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 BCAP31 10134
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
13 BNIP1 662
Invivo Homo sapiens
Two-hybrid Homo sapiens
14 SPNS1 83985
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
15 BCL2L11  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
16 Bcl2l11  
Protein-peptide Mus musculus
17 FKBP8 23770
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
18 ANTXR1 84168
Affinity Capture-MS Homo sapiens
19 RTN4 57142
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
20 IRS1 3667
Affinity Capture-Western Homo sapiens
21 PSEN2 5664
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
22 BLK 640
Reconstituted Complex Homo sapiens
23 BIK  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 RAD9A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
25 BAK1 578
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
26 CASP9 842
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
27 BCL2  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
28 PMAIP1  
Invivo Homo sapiens
Protein-peptide Homo sapiens
29 HRK  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
FRET Homo sapiens
30 BCL2L12 83596
Affinity Capture-MS Homo sapiens
31 ZNFN1A3  
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
32 RAF1 5894
Reconstituted Complex Homo sapiens
33 BECN1 8678
Two-hybrid Homo sapiens
34 CYCS 54205
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
35 VDAC1 7416
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
36 BCL2L14  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
37 CFLAR  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
38 BNIP3L  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
39 BAG1 573
Affinity Capture-MS Homo sapiens
40 RTN1 6252
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
41 BNIPL  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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