Gene description for TMEM259
Gene name transmembrane protein 259
Gene symbol TMEM259
Other names/aliases ASBABP1
C19orf6
MBRL
MEMBRALIN
R32184_3
Species Homo sapiens
 Database cross references - TMEM259
ExoCarta ExoCarta_91304
Vesiclepedia VP_91304
Entrez Gene 91304
HGNC 17039
MIM 611011
UniProt Q4ZIN3  
 TMEM259 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM259
Biological Process
    response to endoplasmic reticulum stress GO:0034976 IBA
    positive regulation of ERAD pathway GO:1904294 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified TMEM259 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM259
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 ST3GAL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 EMC6 83460
Affinity Capture-MS Homo sapiens
4 B3GALT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TSPAN16  
Affinity Capture-MS Homo sapiens
6 C5AR1  
Affinity Capture-MS Homo sapiens
7 SCGB1D2  
Affinity Capture-MS Homo sapiens
8 CCKBR  
Affinity Capture-MS Homo sapiens
9 LPPR2  
Affinity Capture-MS Homo sapiens
10 SLC25A3 5250
Affinity Capture-MS Homo sapiens
11 VOPP1  
Affinity Capture-MS Homo sapiens
12 TNF  
Affinity Capture-MS Homo sapiens
13 SLC35C1  
Affinity Capture-MS Homo sapiens
14 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 FAM57A  
Affinity Capture-MS Homo sapiens
16 ZDHHC7  
Affinity Capture-MS Homo sapiens
17 S1PR1 1901
Affinity Capture-MS Homo sapiens
18 TMEM223  
Affinity Capture-MS Homo sapiens
19 EXTL3 2137
Affinity Capture-MS Homo sapiens
20 ADRB2  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
21 LHFPL1  
Affinity Capture-MS Homo sapiens
22 GPR182  
Affinity Capture-MS Homo sapiens
23 EDEM1  
Affinity Capture-MS Homo sapiens
24 P2RY2 5029
Affinity Capture-MS Homo sapiens
25 TMEM199  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SPSB4  
Affinity Capture-MS Homo sapiens
27 TYROBP  
Affinity Capture-MS Homo sapiens
28 TMUB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ERLIN2 11160
Affinity Capture-MS Homo sapiens
30 GPR27  
Affinity Capture-MS Homo sapiens
31 TMEM155  
Affinity Capture-MS Homo sapiens
32 ATP1B3 483
Affinity Capture-MS Homo sapiens
33 APOC4  
Affinity Capture-MS Homo sapiens
34 C8orf74  
Affinity Capture-MS Homo sapiens
35 OR4N2  
Affinity Capture-MS Homo sapiens
36 ATP1B1 481
Affinity Capture-MS Homo sapiens
37 TMEM173  
Affinity Capture-MS Homo sapiens
38 MS4A15  
Affinity Capture-MS Homo sapiens
39 ATP6V0C 527
Affinity Capture-MS Homo sapiens
40 SSTR1 6751
Affinity Capture-MS Homo sapiens
41 APOA2 336
Affinity Capture-MS Homo sapiens
42 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
43 BCL2  
Affinity Capture-MS Homo sapiens
44 RNF5  
Affinity Capture-MS Homo sapiens
45 GPR88  
Affinity Capture-MS Homo sapiens
46 FAM69A 388650
Affinity Capture-MS Homo sapiens
47 OR6T1  
Affinity Capture-MS Homo sapiens
48 APOC3 345
Affinity Capture-MS Homo sapiens
49 S1PR4  
Affinity Capture-MS Homo sapiens
50 GPR21  
Affinity Capture-MS Homo sapiens
51 ASPH 444
Affinity Capture-MS Homo sapiens
52 FAM189A2  
Affinity Capture-MS Homo sapiens
53 CLSTN1 22883
Affinity Capture-MS Homo sapiens
54 STYK1  
Affinity Capture-MS Homo sapiens
55 SPSB2  
Affinity Capture-MS Homo sapiens
56 BCL2L1 598
Affinity Capture-MS Homo sapiens
57 P2RX2  
Affinity Capture-MS Homo sapiens
58 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TNFRSF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 CNR2  
Affinity Capture-MS Homo sapiens
61 CD3E 916
Affinity Capture-MS Homo sapiens
62 RNF185  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
63 ANKRD46 157567
Affinity Capture-MS Homo sapiens
64 B3GAT3 26229
Affinity Capture-MS Homo sapiens
65 LHFPL5  
Affinity Capture-MS Homo sapiens
66 TNFSF18 8995
Affinity Capture-MS Homo sapiens
67 GPR173  
Affinity Capture-MS Homo sapiens
68 CMKLR1 1240
Affinity Capture-MS Homo sapiens
69 TMCO3 55002
Affinity Capture-MS Homo sapiens
70 PTAFR  
Affinity Capture-MS Homo sapiens
71 ABHD14A  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM259 is involved
No pathways found





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