Gene description for SSTR1
Gene name somatostatin receptor 1
Gene symbol SSTR1
Other names/aliases SRIF-2
SS-1-R
SS1-R
SS1R
Species Homo sapiens
 Database cross references - SSTR1
ExoCarta ExoCarta_6751
Entrez Gene 6751
HGNC 11330
MIM 182451
UniProt P30872  
 SSTR1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SSTR1
Molecular Function
    somatostatin receptor activity GO:0004994 IDA
    neuropeptide binding GO:0042923 IBA
Biological Process
    cell surface receptor signaling pathway GO:0007166 TAS
    synaptic transmission GO:0007268 IBA
    spermatogenesis GO:0007283 IEA
    cerebellum development GO:0021549 IEA
    response to starvation GO:0042594 IEA
    cell-cell signaling GO:0007267 TAS
    response to nutrient GO:0007584 TAS
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS
    digestion GO:0007586 TAS
    somatostatin signaling pathway GO:0038170 IBA
    forebrain development GO:0030900 IEA
    negative regulation of cell proliferation GO:0008285 TAS
    glutamate receptor signaling pathway GO:0007215 IEA
    neuropeptide signaling pathway GO:0007218 IBA
    cellular response to estradiol stimulus GO:0071392 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 TAS
    neuron projection GO:0043005 IBA
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified SSTR1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SSTR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CORT  
Invivo Homo sapiens
Invivo Homo sapiens
2 SST  
Invivo Homo sapiens
3 SSTR5  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SSTR1 is involved
PathwayEvidenceSource
G alpha (i) signalling events TAS Reactome
Peptide ligand-binding receptors TAS Reactome





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