Gene description for HLA-DQA1
Gene name major histocompatibility complex, class II, DQ alpha 1
Gene symbol HLA-DQA1
Other names/aliases CD
CELIAC1
DQ-A1
GSE
HLA-DQA
Species Homo sapiens
 Database cross references - HLA-DQA1
ExoCarta ExoCarta_3117
Entrez Gene 3117
HGNC 4942
MIM 146880
UniProt P01909  
 HLA-DQA1 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for HLA-DQA1
Molecular Function
    MHC class II receptor activity GO:0032395 TAS
    peptide antigen binding GO:0042605 ISS
Biological Process
    immune response GO:0006955 NAS
    T cell costimulation GO:0031295 TAS
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    T cell receptor signaling pathway GO:0050852 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
Subcellular Localization
    trans-Golgi network membrane GO:0032588 TAS
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    MHC class II protein complex GO:0042613 ISS
    integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 TAS
    endocytic vesicle membrane GO:0030666 TAS
    integral component of plasma membrane GO:0005887 NAS
    Golgi membrane GO:0000139 TAS
    membrane GO:0016020 IDA
    endosome membrane GO:0010008 IEA
    ER to Golgi transport vesicle membrane GO:0012507 TAS
    lysosomal membrane GO:0005765 TAS
    plasma membrane GO:0005886 TAS
    transport vesicle membrane GO:0030658 TAS
 Experiment description of studies that identified HLA-DQA1 in exosomes
1
Experiment ID 79
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for HLA-DQA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APLP1  
Two-hybrid Homo sapiens
2 RIF1  
Two-hybrid Homo sapiens
3 TLE1  
Two-hybrid Homo sapiens
4 UNC119  
Two-hybrid Homo sapiens
5 SH3GL2  
Two-hybrid Homo sapiens
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