Gene description for TAPBP
Gene name TAP binding protein (tapasin)
Gene symbol TAPBP
Other names/aliases NGS17
TAPA
TPN
TPSN
Species Homo sapiens
 Database cross references - TAPBP
ExoCarta ExoCarta_6892
Entrez Gene 6892
HGNC 11566
MIM 601962
UniProt O15533  
 TAPBP identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
 Gene ontology annotations for TAPBP
Molecular Function
    TAP1 binding GO:0046978 TAS
    MHC class I protein binding GO:0042288 TAS
    TAP2 binding GO:0046979 TAS
    peptide antigen-transporting ATPase activity GO:0015433 TAS
    protein binding GO:0005515 IPI
    unfolded protein binding GO:0051082 TAS
    peptide antigen binding GO:0042605 TAS
Biological Process
    antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 IEA
    amide transport GO:0042886 TAS
    immune response GO:0006955 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS
    retrograde vesicle-mediated transport, Golgi to ER GO:0006890 NAS
    protein complex assembly GO:0006461 TAS
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
    peptide antigen stabilization GO:0050823 ISS
    peptide transport GO:0015833 TAS
Subcellular Localization
    integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 TAS
    TAP complex GO:0042825 IDA
    MHC class I peptide loading complex GO:0042824 NAS
    endoplasmic reticulum GO:0005783 TAS
    endoplasmic reticulum membrane GO:0005789 IDA
    Golgi membrane GO:0000139 IDA
    integral component of membrane GO:0016021 TAS
 Experiment description of studies that identified TAPBP in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TAPBP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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