Gene description for FAM20C
Gene name family with sequence similarity 20, member C
Gene symbol FAM20C
Other names/aliases DMP-4
DMP4
GEF-CK
RNS
Species Homo sapiens
 Database cross references - FAM20C
ExoCarta ExoCarta_56975
Entrez Gene 56975
HGNC 22140
MIM 611061
UniProt Q8IXL6  
 FAM20C identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for FAM20C
Molecular Function
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activity GO:0004674 IDA
    calcium ion binding GO:0005509 IEA
Biological Process
    protein phosphorylation GO:0006468 IEA
    dentinogenesis GO:0097187 IEA
    positive regulation of bone mineralization GO:0030501 IEA
    positive regulation of osteoblast differentiation GO:0045669 IEA
    regulation of fibroblast growth factor receptor signaling pathway GO:0040036 IEA
    enamel mineralization GO:0070166 IEA
    odontoblast differentiation GO:0071895 IEA
    osteoclast maturation GO:0036179 IEA
    regulation of phosphorus metabolic process GO:0051174 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    Golgi apparatus GO:0005794 IDA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified FAM20C in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FAM20C
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FAM20C is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here