Gene description for FAM20C
Gene name family with sequence similarity 20, member C
Gene symbol FAM20C
Other names/aliases DMP-4
DMP4
GEF-CK
RNS
Species Homo sapiens
 Database cross references - FAM20C
ExoCarta ExoCarta_56975
Vesiclepedia VP_56975
Entrez Gene 56975
HGNC 22140
MIM 611061
UniProt Q8IXL6  
 FAM20C identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for FAM20C
Molecular Function
    protease binding GO:0002020 IPI
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    manganese ion binding GO:0030145 IDA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    positive regulation of bone mineralization GO:0030501 IEA
    biomineral tissue development GO:0031214 IMP
    osteoclast maturation GO:0036179 IEA
    regulation of fibroblast growth factor receptor signaling pathway GO:0040036 IEA
    post-translational protein modification GO:0043687 TAS
    positive regulation of osteoblast differentiation GO:0045669 IEA
    regulation of phosphorus metabolic process GO:0051174 IEA
    enamel mineralization GO:0070166 IBA
    odontoblast differentiation GO:0071895 IEA
    dentinogenesis GO:0097187 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    extracellular space GO:0005615 IDA
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    Golgi apparatus GO:0005794 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FAM20C in exosomes
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FAM20C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POR 5447
Affinity Capture-MS Homo sapiens
2 EPM2AIP1 9852
Affinity Capture-MS Homo sapiens
3 STT3A 3703
Affinity Capture-MS Homo sapiens
4 TK1 7083
Two-hybrid Homo sapiens
5 CRTAP 10491
Affinity Capture-MS Homo sapiens
6 SACM1L 22908
Affinity Capture-MS Homo sapiens
7 SQSTM1 8878
Affinity Capture-MS Homo sapiens
8 P4HA2 8974
Affinity Capture-MS Homo sapiens
9 ALB 213
Affinity Capture-MS Homo sapiens
10 VMP1 81671
Affinity Capture-MS Homo sapiens
11 HSPA13 6782
Affinity Capture-MS Homo sapiens
12 COPB2 9276
Affinity Capture-MS Homo sapiens
13 ARCN1 372
Affinity Capture-MS Homo sapiens
14 CAND1 55832
Affinity Capture-MS Homo sapiens
15 HNRNPR 10236
Affinity Capture-MS Homo sapiens
16 PTPN1 5770
Affinity Capture-MS Homo sapiens
17 ASPH 444
Affinity Capture-MS Homo sapiens
18 COPA 1314
Affinity Capture-MS Homo sapiens
19 HSPA5 3309
Affinity Capture-MS Homo sapiens
20 RUVBL1 8607
Affinity Capture-MS Homo sapiens
21 ARFGAP2 84364
Affinity Capture-MS Homo sapiens
22 STK26 51765
Affinity Capture-MS Homo sapiens
23 SGPL1 8879
Affinity Capture-MS Homo sapiens
24 SMPD4 55627
Affinity Capture-MS Homo sapiens
25 YES1 7525
Affinity Capture-MS Homo sapiens
26 B4GALT7 11285
Affinity Capture-MS Homo sapiens
27 GLT8D2 83468
Affinity Capture-MS Homo sapiens
28 QPCTL 54814
Affinity Capture-MS Homo sapiens
29 HADHB 3032
Affinity Capture-MS Homo sapiens
30 STX18 53407
Affinity Capture-MS Homo sapiens
31 DDOST 1650
Affinity Capture-MS Homo sapiens
32 UBQLN1 29979
Affinity Capture-MS Homo sapiens
33 HSP90B1 7184
Affinity Capture-MS Homo sapiens
34 STIP1 10963
Affinity Capture-MS Homo sapiens
35 STAU2 27067
Affinity Capture-MS Homo sapiens
36 SERPINH1 871
Affinity Capture-MS Homo sapiens
37 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
38 CCDC47 57003
Affinity Capture-MS Homo sapiens
39 EEF1G 1937
Affinity Capture-MS Homo sapiens
40 P3H1 64175
Affinity Capture-MS Homo sapiens
41 EOGT 285203
Affinity Capture-MS Homo sapiens
42 MTDH 92140
Affinity Capture-MS Homo sapiens
43 TOR3A 64222
Affinity Capture-MS Homo sapiens
44 DDX41 51428
Affinity Capture-MS Homo sapiens
45 TMEM106A  
Affinity Capture-MS Homo sapiens
46 IMPAD1 54928
Affinity Capture-MS Homo sapiens
47 FAM20C 56975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 DHCR7 1717
Affinity Capture-MS Homo sapiens
49 GLT8D1 55830
Affinity Capture-MS Homo sapiens
50 AP3M1 26985
Affinity Capture-MS Homo sapiens
51 ANXA7 310
Affinity Capture-MS Homo sapiens
52 ATP2A2 488
Affinity Capture-MS Homo sapiens
53 TCP1 6950
Affinity Capture-MS Homo sapiens
54 P4HA1 5033
Affinity Capture-MS Homo sapiens
55 SLC1A5 6510
Affinity Capture-MS Homo sapiens
56 ERO1L 30001
Affinity Capture-MS Homo sapiens
57 IKBIP 121457
Affinity Capture-MS Homo sapiens
58 EMD 2010
Affinity Capture-MS Homo sapiens
59 VPS45 11311
Affinity Capture-MS Homo sapiens
60 TBL2 26608
Affinity Capture-MS Homo sapiens
61 CLU 1191
Affinity Capture-MS Homo sapiens
62 TMEM165 55858
Affinity Capture-MS Homo sapiens
63 COPG1 22820
Affinity Capture-MS Homo sapiens
64 FADS1 3992
Affinity Capture-MS Homo sapiens
65 COPB1 1315
Affinity Capture-MS Homo sapiens
66 POFUT1 23509
Affinity Capture-MS Homo sapiens
67 TMEM43 79188
Affinity Capture-MS Homo sapiens
68 PLOD2 5352
Affinity Capture-MS Homo sapiens
69 CDKAL1  
Affinity Capture-MS Homo sapiens
70 FAM118B  
Two-hybrid Homo sapiens
71 VCP 7415
Affinity Capture-MS Homo sapiens
72 BACE2 25825
Affinity Capture-MS Homo sapiens
73 PIGT 51604
Affinity Capture-MS Homo sapiens
74 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
75 APMAP 57136
Affinity Capture-MS Homo sapiens
76 HM13 81502
Affinity Capture-MS Homo sapiens
77 ZMPSTE24 10269
Affinity Capture-MS Homo sapiens
78 P4HB 5034
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
79 RPN1 6184
Affinity Capture-MS Homo sapiens
80 PCSK9 255738
Affinity Capture-MS Homo sapiens
81 PIGS 94005
Affinity Capture-MS Homo sapiens
82 AP3B1 8546
Affinity Capture-MS Homo sapiens
83 PDIA6 10130
Affinity Capture-MS Homo sapiens
84 CDC42EP1 11135
Affinity Capture-MS Homo sapiens
85 SDF4 51150
Affinity Capture-MS Homo sapiens
86 PICALM 8301
Affinity Capture-MS Homo sapiens
87 SLC33A1 9197
Affinity Capture-MS Homo sapiens
88 DNAJB11 51726
Affinity Capture-MS Homo sapiens
89 ARFGAP1 55738
Affinity Capture-MS Homo sapiens
90 ACBD3 64746
Affinity Capture-MS Homo sapiens
91 ERGIC3 51614
Affinity Capture-MS Homo sapiens
92 CAT 847
Affinity Capture-MS Homo sapiens
93 ALG1 56052
Affinity Capture-MS Homo sapiens
94 DNAJB14  
Affinity Capture-MS Homo sapiens
95 TMPO 7112
Affinity Capture-MS Homo sapiens
96 RAP1GDS1 5910
Affinity Capture-MS Homo sapiens
97 IPO5 3843
Affinity Capture-MS Homo sapiens
98 GPAA1 8733
Affinity Capture-MS Homo sapiens
99 MBOAT7 79143
Affinity Capture-MS Homo sapiens
100 RPN2 6185
Affinity Capture-MS Homo sapiens
101 ERLEC1 27248
Affinity Capture-MS Homo sapiens
102 CANX 821
Affinity Capture-MS Homo sapiens
103 ATL3 25923
Affinity Capture-MS Homo sapiens
104 UGGT1 56886
Affinity Capture-MS Homo sapiens
105 TXNDC5 81567
Affinity Capture-MS Homo sapiens
106 ZNF622 90441
Affinity Capture-MS Homo sapiens
107 SLC27A4 10999
Affinity Capture-MS Homo sapiens
108 DLG1 1739
Affinity Capture-MS Homo sapiens
109 CALR 811
Affinity Capture-MS Homo sapiens
110 ASS1 445
Affinity Capture-MS Homo sapiens
111 S100A7 6278
Affinity Capture-MS Homo sapiens
112 PDIA3 2923
Affinity Capture-MS Homo sapiens
113 EPHX1 2052
Affinity Capture-MS Homo sapiens
114 TRIM68 55128
Affinity Capture-MS Homo sapiens
115 YIPF5 81555
Affinity Capture-MS Homo sapiens
116 PIGK 10026
Affinity Capture-MS Homo sapiens
117 RCN1 5954
Affinity Capture-MS Homo sapiens
118 GDI2 2665
Affinity Capture-MS Homo sapiens
119 ERP44 23071
Affinity Capture-MS Homo sapiens
120 AKAP8  
Affinity Capture-MS Homo sapiens
121 TAPBP 6892
Affinity Capture-MS Homo sapiens
122 RETSAT 54884
Affinity Capture-MS Homo sapiens
123 IST1 9798
Affinity Capture-MS Homo sapiens
124 NUCB1 4924
Affinity Capture-MS Homo sapiens
125 SET 6418
Affinity Capture-MS Homo sapiens
126 EGFR 1956
Affinity Capture-MS Homo sapiens
127 SUV39H2 79723
Two-hybrid Homo sapiens
128 GLA 2717
Affinity Capture-MS Homo sapiens
129 PLIN3 10226
Affinity Capture-MS Homo sapiens
130 NCLN 56926
Affinity Capture-MS Homo sapiens
131 DNAJC10 54431
Affinity Capture-MS Homo sapiens
132 RCN2 5955
Affinity Capture-MS Homo sapiens
133 DDRGK1 65992
Affinity Capture-MS Homo sapiens
134 GALNT2 2590
Affinity Capture-MS Homo sapiens
135 GANAB 23193
Affinity Capture-MS Homo sapiens
136 HSPD1 3329
Affinity Capture-MS Homo sapiens
137 HLA-A 3105
Affinity Capture-MS Homo sapiens
138 ALG2 85365
Affinity Capture-MS Homo sapiens
139 PDIA5 10954
Affinity Capture-MS Homo sapiens
140 XXYLT1 152002
Affinity Capture-MS Homo sapiens
141 AHSA1 10598
Affinity Capture-MS Homo sapiens
142 LBR 3930
Affinity Capture-MS Homo sapiens
143 MAP2K2 5605
Affinity Capture-MS Homo sapiens
144 ALDH3A2 224
Affinity Capture-MS Homo sapiens
145 SMN1 6606
Two-hybrid Homo sapiens
146 UBXN4 23190
Affinity Capture-MS Homo sapiens
147 WDR77 79084
Affinity Capture-MS Homo sapiens
148 RRS1 23212
Affinity Capture-MS Homo sapiens
149 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
150 EHD4 30844
Affinity Capture-MS Homo sapiens
151 CALU 813
Affinity Capture-MS Homo sapiens
152 KEAP1 9817
Affinity Capture-MS Homo sapiens
153 BST2 684
Affinity Capture-MS Homo sapiens
154 PFDN1 5201
Two-hybrid Homo sapiens
155 SIL1 64374
Affinity Capture-MS Homo sapiens
156 ERLIN2 11160
Affinity Capture-MS Homo sapiens
157 FKBP9 11328
Affinity Capture-MS Homo sapiens
158 FKBP4 2288
Affinity Capture-MS Homo sapiens
159 PTPN2 5771
Affinity Capture-MS Homo sapiens
160 SLC39A14 23516
Affinity Capture-MS Homo sapiens
161 TAF1D  
Two-hybrid Homo sapiens
162 DDX58 23586
Affinity Capture-RNA Homo sapiens
163 MAP2K1 5604
Affinity Capture-MS Homo sapiens
164 EDEM2  
Affinity Capture-MS Homo sapiens
165 SPTLC2 9517
Affinity Capture-MS Homo sapiens
166 AUP1 550
Affinity Capture-MS Homo sapiens
167 PREB 10113
Affinity Capture-MS Homo sapiens
168 ST3GAL4 6484
Affinity Capture-MS Homo sapiens
169 ERGIC2 51290
Affinity Capture-MS Homo sapiens
170 PLD3 23646
Affinity Capture-MS Homo sapiens
171 LRPAP1 4043
Affinity Capture-MS Homo sapiens
172 TSC22D1 8848
Two-hybrid Homo sapiens
173 SEC62 7095
Affinity Capture-MS Homo sapiens
174 ATP1A1 476
Affinity Capture-MS Homo sapiens
175 INPP5K 51763
Affinity Capture-MS Homo sapiens
176 NCEH1 57552
Affinity Capture-MS Homo sapiens
177 CKAP4 10970
Affinity Capture-MS Homo sapiens
178 HLA-C 3107
Affinity Capture-MS Homo sapiens
179 PCYT1A 5130
Affinity Capture-MS Homo sapiens
180 ESYT1 23344
Affinity Capture-MS Homo sapiens
181 FDFT1 2222
Affinity Capture-MS Homo sapiens
182 SEC61A1 29927
Affinity Capture-MS Homo sapiens
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