Gene description for ZMPSTE24
Gene name zinc metallopeptidase STE24
Gene symbol ZMPSTE24
Other names/aliases FACE-1
FACE1
HGPS
PRO1
STE24
Ste24p
Species Homo sapiens
 Database cross references - ZMPSTE24
ExoCarta ExoCarta_10269
Entrez Gene 10269
HGNC 12877
MIM 606480
UniProt O75844  
 ZMPSTE24 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ZMPSTE24
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    metal ion binding GO:0046872 IEA
    metalloexopeptidase activity GO:0008235 TAS
Biological Process
    proteolysis GO:0006508 TAS
    prenylated protein catabolic process GO:0030327 IEA
    CAAX-box protein processing GO:0071586 IEA
    nuclear envelope organization GO:0006998 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    extracellular exosome GO:0070062 IDA
    nuclear inner membrane GO:0005637 IEA
    membrane GO:0016020 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified ZMPSTE24 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ZMPSTE24
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ZMPSTE24 is involved
No pathways found





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