Gene description for IL7
Gene name interleukin 7
Gene symbol IL7
Other names/aliases IL-7
Species Homo sapiens
 Database cross references - IL7
ExoCarta ExoCarta_3574
Entrez Gene 3574
HGNC 6023
MIM 146660
UniProt P13232  
 IL7 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL7
Molecular Function
    protein binding GO:0005515 IPI
    cytokine activity GO:0005125 IBA
    interleukin-7 receptor binding GO:0005139 IEA
    growth factor activity GO:0008083 ISS
Biological Process
    negative regulation of apoptotic process GO:0043066 ISS
    T cell lineage commitment GO:0002360 IBA
    positive regulation of T cell differentiation GO:0045582 ISS
    positive regulation of cell proliferation GO:0008284 TAS
    cell-cell signaling GO:0007267 TAS
    humoral immune response GO:0006959 TAS
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IEA
    regulation of gene expression GO:0010468 IEA
    negative regulation of catalytic activity GO:0043086 IEA
    homeostasis of number of cells within a tissue GO:0048873 IEA
    positive regulation of organ growth GO:0046622 IEA
    organ morphogenesis GO:0009887 TAS
    positive regulation of B cell proliferation GO:0030890 ISS
    bone resorption GO:0045453 ISS
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified IL7 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IL2RG  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which IL7 is involved
PathwayEvidenceSource
Interleukin-7 signaling TAS Reactome





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