Gene description for NOTCH3
Gene name notch 3
Gene symbol NOTCH3
Other names/aliases CADASIL
Species Homo sapiens
 Database cross references - NOTCH3
ExoCarta ExoCarta_4854
Entrez Gene 4854
HGNC 7883
MIM 600276
UniProt Q9UM47  
 NOTCH3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NOTCH3
Molecular Function
    enzyme binding GO:0019899 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    negative regulation of neuron differentiation GO:0045665 IEA
    Notch signaling pathway GO:0007219 TAS
    gene expression GO:0010467 TAS
    forebrain development GO:0030900 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    neuron fate commitment GO:0048663 IEA
    Notch receptor processing GO:0007220 TAS
    glomerular capillary formation GO:0072104 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    integral component of membrane GO:0016021 IEA
    extracellular region GO:0005576 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    Golgi membrane GO:0000139 TAS
    actin cytoskeleton GO:0015629 IDA
    nucleoplasm GO:0005654 TAS
    plasma membrane GO:0005886 TAS
    cytoplasm GO:0005737 IDA
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified NOTCH3 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NOTCH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DLL1  
Reconstituted Complex Homo sapiens
2 JAG2  
Reconstituted Complex Homo sapiens
3 MAML1  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
5 JAG1 182
Reconstituted Complex Homo sapiens
6 NOTCH1 4851
Phenotypic Suppression Homo sapiens
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