Gene description for EGFL7
Gene name EGF-like-domain, multiple 7
Gene symbol EGFL7
Other names/aliases NEU1
VE-STATIN
ZNEU1
Species Homo sapiens
 Database cross references - EGFL7
ExoCarta ExoCarta_51162
Entrez Gene 51162
HGNC 20594
MIM 608582
UniProt Q9UHF1  
 EGFL7 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for EGFL7
Molecular Function
    calcium ion binding GO:0005509 IEA
    Notch binding GO:0005112 IEA
Biological Process
    blood vessel development GO:0001568 ISS
    negative regulation of Notch signaling pathway GO:0045746 IMP
    vasculogenesis GO:0001570 ISS
    cell adhesion GO:0007155 IEA
    angiogenesis GO:0001525 IEA
    negative regulation of cell migration GO:0030336 IEA
    positive regulation of endothelial cell proliferation GO:0001938 IMP
Subcellular Localization
    extracellular matrix GO:0031012 IDA
    extracellular space GO:0005615 IEA
    extracellular region GO:0005576 ISS
 Experiment description of studies that identified EGFL7 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EGFL7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which EGFL7 is involved
No pathways found





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