Gene description for Notch2
Gene name notch 2
Gene symbol Notch2
Other names/aliases AI853703
N2
Species Mus musculus
 Database cross references - Notch2
ExoCarta ExoCarta_18129
Vesiclepedia VP_18129
Entrez Gene 18129
UniProt O35516  
 Notch2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Notch2
Molecular Function
    enzyme binding GO:0019899 IPI
    calcium ion binding GO:0005509 IEA
    NF-kappaB binding GO:0051059 IPI
    protein binding GO:0005515 IPI
Biological Process
    regulation of developmental process GO:0050793 IEA
    positive regulation of apoptotic process GO:0043065 IGI
    pulmonary valve morphogenesis GO:0003184 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    embryonic limb morphogenesis GO:0030326 IGI
    positive regulation of Ras protein signal transduction GO:0046579 ISO
    regulation of transcription from RNA polymerase II promoter GO:0006357 IMP
    inflammatory response to antigenic stimulus GO:0002437 IGI
    positive regulation of osteoclast differentiation GO:0045672 IDA
    in utero embryonic development GO:0001701 IMP
    Notch signaling pathway GO:0007219 TAS
    wound healing GO:0042060 IDA
    interleukin-4 secretion GO:0072602 IGI
    atrial septum morphogenesis GO:0060413 ISO
    myeloid dendritic cell differentiation GO:0043011 IMP
    defense response to bacterium GO:0042742 IMP
    transcription, DNA-templated GO:0006351 IEA
    cell differentiation GO:0030154 IEA
    multicellular organism growth GO:0035264 IMP
    heart looping GO:0001947 IGI
    humoral immune response GO:0006959 IGI
    hepatocyte proliferation GO:0072574 IMP
    positive regulation of cell proliferation GO:0008284 IMP
    organ morphogenesis GO:0009887 TAS
    multicellular organismal development GO:0007275 IEA
    placenta blood vessel development GO:0060674 IMP
    cell growth GO:0016049 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    placenta development GO:0001890 IMP
    intrahepatic bile duct development GO:0035622 IMP
    cholangiocyte proliferation GO:1990705 IMP
    liver morphogenesis GO:0072576 IMP
    ciliary body morphogenesis GO:0061073 IMP
    cell fate determination GO:0001709 TAS
    left/right axis specification GO:0070986 IGI
    liver development GO:0001889 IMP
    cell cycle arrest GO:0007050 ISO
    bone remodeling GO:0046849 ISO
    positive regulation of BMP signaling pathway GO:0030513 IMP
    determination of left/right symmetry GO:0007368 IMP
    morphogenesis of an epithelial sheet GO:0002011 IMP
Subcellular Localization
    cilium GO:0005929 IDA
    receptor complex GO:0043235 ISO
    integral component of membrane GO:0016021 IEA
    integral component of plasma membrane GO:0005887 ISO
    membrane GO:0016020 ISO
    cell surface GO:0009986 ISO
    cell GO:0005623 IGI
    plasma membrane GO:0005886 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Notch2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Notch2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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