Gene description for LTBR
Gene name lymphotoxin beta receptor (TNFR superfamily, member 3)
Gene symbol LTBR
Other names/aliases CD18
D12S370
LT-BETA-R
TNF-R-III
TNFCR
TNFR-RP
TNFR2-RP
TNFR3
TNFRSF3
Species Homo sapiens
 Database cross references - LTBR
ExoCarta ExoCarta_4055
Vesiclepedia VP_4055
Entrez Gene 4055
HGNC 6718
MIM 600979
UniProt P36941  
 LTBR identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for LTBR
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    cellular response to mechanical stimulus GO:0071260 IEP
    myeloid dendritic cell differentiation GO:0043011 IEA
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 TAS
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP
    positive regulation of JNK cascade GO:0046330 IMP
    viral process GO:0016032 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified LTBR in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for LTBR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFSF14  
Affinity Capture-MS Homo sapiens
2 DIABLO 56616
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 LTA  
Invivo Homo sapiens
4 TRAF3 7187
Affinity Capture-Western Homo sapiens
5 TRAF4 9618
Invitro Homo sapiens
6 TRAF5  
Invitro Homo sapiens
Invivo Homo sapiens
7 LTBR 4055
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LTBR is involved
No pathways found





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