Gene description for PLK1
Gene name	polo-like kinase 1
Gene symbol	PLK1
Other names/aliases	PLK STPK13
Species	Homo sapiens
Database cross references - PLK1
ExoCarta	ExoCarta_5347
Entrez Gene	5347
HGNC	9077
MIM	602098
UniProt	P53350
PLK1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for PLK1

Molecular Function     protein serine/threonine kinase activity GO:0004674 IMP     microtubule binding GO:0008017 IDA     protein binding GO:0005515 IPI     protein kinase activity GO:0004672 IDA     protein kinase binding GO:0019901 IPI     kinase activity GO:0016301 TAS     ATP binding GO:0005524 IEA     anaphase-promoting complex binding GO:0010997 IPI Biological Process     microtubule bundle formation GO:0001578 IDA     activation of APC-Cdc20 complex activity GO:0007092 IDA     mitotic cell cycle GO:0000278 TAS     anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 TAS     mitotic nuclear envelope disassembly GO:0007077 TAS     mitotic nuclear division GO:0007067 IMP     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS     regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS     regulation of mitotic metaphase/anaphase transition GO:0030071 IMP     cell proliferation GO:0008283 TAS     cytokinesis GO:0000910 IMP     mitotic spindle assembly checkpoint GO:0007094 IMP     protein destabilization GO:0031648 IDA     negative regulation of apoptotic process GO:0043066 IMP     establishment of protein localization GO:0045184 IMP     mitotic sister chromatid segregation GO:0000070 IMP     response to antibiotic GO:0046677 IEA     regulation of mitotic cell cycle GO:0007346 IMP     protein phosphorylation GO:0006468 IDA     peptidyl-serine phosphorylation GO:0018105 IDA     polar body extrusion after meiotic divisions GO:0040038 IEA     regulation of protein binding GO:0043393 IMP     G2/M transition of mitotic cell cycle GO:0000086 TAS     negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IMP     protein ubiquitination GO:0016567 IDA     centrosome organization GO:0051297 IMP     regulation of cell cycle GO:0051726 TAS     metaphase/anaphase transition of mitotic cell cycle GO:0007091 TAS     positive regulation of peptidyl-threonine phosphorylation GO:0010800 IMP     regulation of mitotic spindle assembly GO:1901673 IDA     mitotic cytokinesis GO:0000281 IDA     small GTPase mediated signal transduction GO:0007264 TAS     positive regulation of ubiquitin-protein transferase activity GO:0051443 IMP     organelle organization GO:0006996 TAS     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP     positive regulation of proteolysis GO:0045862 IDA     protein localization to chromatin GO:0071168 IDA     G2 DNA damage checkpoint GO:0031572 IDA Subcellular Localization     spindle midzone GO:0051233 IDA     centrosome GO:0005813 IDA     midbody GO:0030496 IDA     nucleoplasm GO:0005654 TAS     microtubule cytoskeleton GO:0015630 IDA     cytosol GO:0005829 TAS     spindle microtubule GO:0005876 IDA     nucleus GO:0005634 IDA     kinetochore GO:0000776 IDA     spindle GO:0005819 IDA     spindle pole GO:0000922 IDA     nucleolus GO:0005730 IDA     condensed nuclear chromosome outer kinetochore GO:0000942 IDA     cytoplasm GO:0005737 IDA