Gene description for STXBP4
Gene name syntaxin binding protein 4
Gene symbol STXBP4
Other names/aliases Synip
Species Homo sapiens
 Database cross references - STXBP4
ExoCarta ExoCarta_252983
Vesiclepedia VP_252983
Entrez Gene 252983
HGNC 19694
MIM 610415
UniProt Q6ZWJ1  
 STXBP4 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for STXBP4
Molecular Function
    protein binding GO:0005515 IPI
    syntaxin binding GO:0019905 IBA
    syntaxin binding GO:0019905 IPI
Biological Process
    protein targeting GO:0006605 IEA
    DNA damage response GO:0006974 IDA
    insulin receptor signaling pathway GO:0008286 IBA
    regulation of D-glucose transmembrane transport GO:0010827 IEA
    positive regulation of keratinocyte proliferation GO:0010838 IMP
    protein stabilization GO:0050821 IMP
    regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 IDA
    cellular response to type II interferon GO:0071346 IEA
    positive regulation of cell cycle G1/S phase transition GO:1902808 IMP
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IBA
    phagocytic vesicle GO:0045335 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified STXBP4 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for STXBP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PMEPA1 56937
Affinity Capture-MS Homo sapiens
2 PEX14 5195
Proximity Label-MS Homo sapiens
3 HOMER1  
Affinity Capture-MS Homo sapiens
4 PRRG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ENKD1  
Two-hybrid Homo sapiens
6 VPS16 64601
Affinity Capture-MS Homo sapiens
7 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
8 PRKY  
Affinity Capture-MS Homo sapiens
9 AMOT  
Proximity Label-MS Homo sapiens
10 CBFA2T3  
Affinity Capture-MS Homo sapiens
11 TULP4 56995
Affinity Capture-MS Homo sapiens
12 VPS28 51160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PXN 5829
Proximity Label-MS Homo sapiens
14 TP53 7157
Synthetic Growth Defect Homo sapiens
15 METTL10  
Affinity Capture-MS Homo sapiens
16 CUEDC1 404093
Affinity Capture-MS Homo sapiens
17 EGLN3  
Affinity Capture-MS Homo sapiens
18 NINL  
Proximity Label-MS Homo sapiens
19 CCDC120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 KRT8 3856
Proximity Label-MS Homo sapiens
21 STRN4 29888
Affinity Capture-MS Homo sapiens
22 CDK5RAP2 55755
Proximity Label-MS Homo sapiens
23 PRRG1 5638
Affinity Capture-MS Homo sapiens
24 LDLRAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SUSD6 9766
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CCT8L2  
Affinity Capture-MS Homo sapiens
27 RGS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FAM184A 79632
Proximity Label-MS Homo sapiens
29 SMAD4  
Affinity Capture-MS Homo sapiens
30 HSPA1A 3303
Affinity Capture-MS Homo sapiens
31 ATN1  
Two-hybrid Homo sapiens
32 DUSP16  
Affinity Capture-MS Homo sapiens
33 NPRL2  
Affinity Capture-MS Homo sapiens
34 PMF1  
Affinity Capture-MS Homo sapiens
35 TRIM54  
Two-hybrid Homo sapiens
36 WDTC1 23038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ERP44 23071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 KLHL42  
Two-hybrid Homo sapiens
39 CDR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 LAPTM5 7805
Affinity Capture-MS Homo sapiens
41 MBIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PTPN21 11099
Affinity Capture-MS Homo sapiens
43 C20orf195  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TMEM252  
Affinity Capture-MS Homo sapiens
45 PTPN13 5783
Affinity Capture-MS Homo sapiens
46 NPAS1  
Affinity Capture-MS Homo sapiens
47 FLOT1 10211
Proximity Label-MS Homo sapiens
48 MPP5 64398
Affinity Capture-MS Homo sapiens
49 RFXANK  
Affinity Capture-MS Homo sapiens
50 CIT 11113
Affinity Capture-MS Homo sapiens
51 SPATA2  
Affinity Capture-MS Homo sapiens
52 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 FAM189A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PPARD  
Affinity Capture-MS Homo sapiens
55 ARRDC3 57561
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 LGI1  
Affinity Capture-MS Homo sapiens
57 FBXO28  
Affinity Capture-MS Homo sapiens
58 DYNLL2 140735
Affinity Capture-MS Homo sapiens
59 KIAA0226  
Affinity Capture-MS Homo sapiens
60 LATS1  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 LATS2 26524
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
62 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 LURAP1  
Affinity Capture-MS Homo sapiens
64 Plk1  
Affinity Capture-MS Mus musculus
65 C17orf59 54785
Proximity Label-MS Homo sapiens
66 DGCR2 9993
Affinity Capture-MS Homo sapiens
67 SYCE1  
Affinity Capture-MS Homo sapiens
68 PTPN14 5784
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which STXBP4 is involved
No pathways found





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