Gene description for STXBP4
Gene name syntaxin binding protein 4
Gene symbol STXBP4
Other names/aliases Synip
Species Homo sapiens
 Database cross references - STXBP4
ExoCarta ExoCarta_252983
Entrez Gene 252983
HGNC 19694
MIM 610415
UniProt Q6ZWJ1  
 STXBP4 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for STXBP4
Molecular Function
    syntaxin binding GO:0019905 IPI
    protein binding GO:0005515 IPI
Biological Process
    protein stabilization GO:0050821 IMP
    regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 IDA
    positive regulation of cell cycle G1/S phase transition GO:1902808 IMP
    positive regulation of keratinocyte proliferation GO:0010838 IMP
    protein targeting GO:0006605 IEA
    insulin receptor signaling pathway GO:0008286 IEA
    cellular response to DNA damage stimulus GO:0006974 IDA
    glucose transport GO:0015758 IEA
Subcellular Localization
    intermediate filament cytoskeleton GO:0045111 IDA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified STXBP4 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for STXBP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which STXBP4 is involved
No pathways found





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