Gene description for WDTC1
Gene name WD and tetratricopeptide repeats 1
Gene symbol WDTC1
Other names/aliases ADP
DCAF9
Species Homo sapiens
 Database cross references - WDTC1
ExoCarta ExoCarta_23038
Entrez Gene 23038
HGNC 29175
UniProt Q8N5D0  
 WDTC1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for WDTC1
Molecular Function
    enzyme inhibitor activity GO:0004857 IEA
    histone binding GO:0042393 IEA
    protein binding GO:0005515 IPI
    histone deacetylase binding GO:0042826 IEA
Biological Process
    multicellular organism growth GO:0035264 IEA
    in utero embryonic development GO:0001701 IEA
    negative regulation of fatty acid biosynthetic process GO:0045717 IEA
    regulation of cell size GO:0008361 IEA
    glucose metabolic process GO:0006006 IEA
    cellular chemical homeostasis GO:0055082 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    negative regulation of catalytic activity GO:0043086 IEA
    cellular response to insulin stimulus GO:0032869 IEA
    protein ubiquitination GO:0016567 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified WDTC1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for WDTC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VCL 7414
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which WDTC1 is involved
No pathways found





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