Gene description for DECR2
Gene name 2,4-dienoyl CoA reductase 2, peroxisomal
Gene symbol DECR2
Other names/aliases PDCR
SDR17C1
Species Homo sapiens
 Database cross references - DECR2
ExoCarta ExoCarta_26063
Vesiclepedia VP_26063
Entrez Gene 26063
HGNC 2754
MIM 615839
UniProt Q9NUI1  
 DECR2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for DECR2
Molecular Function
    protein binding GO:0005515 IPI
    2,4-dienoyl-CoA reductase (NADPH) activity GO:0008670 IBA
    2,4-dienoyl-CoA reductase (NADPH) activity GO:0008670 IDA
    trans-2-enoyl-CoA reductase (NADPH) activity GO:0019166 IDA
    trans-2-enoyl-CoA reductase (NADPH) activity GO:0019166 TAS
Biological Process
    fatty acid metabolic process GO:0006631 IBA
    unsaturated fatty acid biosynthetic process GO:0006636 IDA
    fatty acid beta-oxidation using acyl-CoA oxidase GO:0033540 TAS
Subcellular Localization
    peroxisome GO:0005777 IBA
    peroxisomal membrane GO:0005778 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified DECR2 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for DECR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAMP3  
Affinity Capture-MS Homo sapiens
2 LIMA1 51474
Affinity Capture-MS Homo sapiens
3 GBP3  
Affinity Capture-MS Homo sapiens
4 Myh9 17886
Affinity Capture-MS Mus musculus
5 TMPRSS5  
Affinity Capture-MS Homo sapiens
6 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
7 ATP1A3 478
Affinity Capture-MS Homo sapiens
8 MFSD4  
Affinity Capture-MS Homo sapiens
9 C14orf119  
Two-hybrid Homo sapiens
10 BSG 682
Affinity Capture-MS Homo sapiens
11 OSTM1 28962
Affinity Capture-MS Homo sapiens
12 PDGFRA 5156
Affinity Capture-MS Homo sapiens
13 DSCR3 10311
Two-hybrid Homo sapiens
14 TRIM26 7726
Affinity Capture-MS Homo sapiens
15 UBC 7316
Reconstituted Complex Homo sapiens
16 USP11 8237
Two-hybrid Homo sapiens
17 TRIM55  
Two-hybrid Homo sapiens
18 CAPZB 832
Affinity Capture-MS Homo sapiens
19 FFAR1  
Affinity Capture-MS Homo sapiens
20 OSGIN1  
Two-hybrid Homo sapiens
21 APP 351
Reconstituted Complex Homo sapiens
22 WDTC1 23038
Affinity Capture-MS Homo sapiens
23 RNASEH2A 10535
Affinity Capture-MS Homo sapiens
24 Flnb 286940
Affinity Capture-MS Mus musculus
25 GPR45  
Affinity Capture-MS Homo sapiens
26 ATP2B2 491
Affinity Capture-MS Homo sapiens
27 GORASP2 26003
Affinity Capture-MS Homo sapiens
28 TRIM63  
Two-hybrid Homo sapiens
29 SESTD1 91404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ESRP2 80004
Affinity Capture-MS Homo sapiens
31 ZUFSP 221302
Affinity Capture-MS Homo sapiens
32 PEX5 5830
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
33 GLMP 112770
Affinity Capture-MS Homo sapiens
34 Coro1c 23790
Affinity Capture-MS Mus musculus
35 GPR107 57720
Affinity Capture-MS Homo sapiens
36 PDZK1 5174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 TSEN15 116461
Affinity Capture-MS Homo sapiens
38 AGPS 8540
Proximity Label-MS Homo sapiens
39 PPP2CB 5516
Affinity Capture-MS Homo sapiens
40 NEDD4L 23327
Reconstituted Complex Homo sapiens
41 CUL4A 8451
Affinity Capture-MS Homo sapiens
42 EP300 2033
Two-hybrid Homo sapiens
43 ITGA8 8516
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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