Gene description for SESTD1
Gene name SEC14 and spectrin domains 1
Gene symbol SESTD1
Other names/aliases SOLO
Species Homo sapiens
 Database cross references - SESTD1
ExoCarta ExoCarta_91404
Entrez Gene 91404
HGNC 18379
UniProt Q86VW0  
 SESTD1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SESTD1
Molecular Function
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    phosphatidylserine binding GO:0001786 IDA
    phosphatidylcholine binding GO:0031210 IDA
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
    1-phosphatidylinositol binding GO:0005545 IDA
    phosphatidic acid binding GO:0070300 IDA
    phosphatidylinositol-4-phosphate binding GO:0070273 IDA
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA
    phosphatidylinositol-5-phosphate binding GO:0010314 IDA
Subcellular Localization
    calcium channel complex GO:0034704 IPI
 Experiment description of studies that identified SESTD1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SESTD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SESTD1 is involved
No pathways found





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