Gene description for LZTS2
Gene name leucine zipper, putative tumor suppressor 2
Gene symbol LZTS2
Other names/aliases LAPSER1
Species Homo sapiens
 Database cross references - LZTS2
ExoCarta ExoCarta_84445
Vesiclepedia VP_84445
Entrez Gene 84445
HGNC 29381
MIM 610454
UniProt Q9BRK4  
 LZTS2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for LZTS2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    mitotic cytokinesis GO:0000281 IEA
    Wnt signaling pathway GO:0016055 IEA
    fibroblast proliferation GO:0048144 IEA
    negative regulation of fibroblast proliferation GO:0048147 IEA
    microtubule severing GO:0051013 IEA
    nuclear export GO:0051168 IEA
    spindle midzone assembly GO:0051255 IEA
    primary ureteric bud growth GO:0060682 IEA
    ureter morphogenesis GO:0072197 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    negative regulation of protein localization to nucleus GO:1900181 IEA
Subcellular Localization
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    microtubule GO:0005874 IEA
    plasma membrane GO:0005886 IDA
    midbody GO:0030496 IEA
    vesicle GO:0031982 IDA
 Experiment description of studies that identified LZTS2 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LZTS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PQBP1  
Two-hybrid Homo sapiens
2 C14orf105  
Two-hybrid Homo sapiens
3 PRR35  
Two-hybrid Homo sapiens
4 RBPMS 11030
Two-hybrid Homo sapiens
5 AES 166
Two-hybrid Homo sapiens
6 RBM41  
Two-hybrid Homo sapiens
7 KPNA2 3838
Two-hybrid Homo sapiens
8 RHOXF2  
Two-hybrid Homo sapiens
9 EIF4E2  
Two-hybrid Homo sapiens
10 SOX2  
Affinity Capture-MS Homo sapiens
11 ZNF426  
Two-hybrid Homo sapiens
12 ARMC7  
Two-hybrid Homo sapiens
13 ZNF446  
Two-hybrid Homo sapiens
14 LMO2  
Two-hybrid Homo sapiens
15 CCNK  
Two-hybrid Homo sapiens
16 CRNKL1 51340
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ACTR3 10096
Proximity Label-MS Homo sapiens
18 PPP1R18 170954
Two-hybrid Homo sapiens
19 PIP4K2B 8396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SMC2 10592
Affinity Capture-MS Homo sapiens
21 TSSK2  
Two-hybrid Homo sapiens
22 C1orf109  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 DGCR6L  
Two-hybrid Homo sapiens
24 GTSE1 51512
Affinity Capture-MS Homo sapiens
25 PPP1R16A 84988
Two-hybrid Homo sapiens
26 BTRC 8945
Affinity Capture-Western Homo sapiens
27 RCOR3  
Two-hybrid Homo sapiens
28 GFI1B  
Two-hybrid Homo sapiens
29 NINL  
Two-hybrid Homo sapiens
30 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 BEX2  
Two-hybrid Homo sapiens
32 LZTS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 MCAM 4162
Proximity Label-MS Homo sapiens
34 COPB1 1315
Two-hybrid Homo sapiens
35 UBASH3B 84959
Two-hybrid Homo sapiens
36 BMS1P5  
Two-hybrid Homo sapiens
37 CDH1 999
Proximity Label-MS Homo sapiens
38 AMPD2 271
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 YAP1 10413
Affinity Capture-MS Homo sapiens
40 MYH9 4627
Affinity Capture-MS Homo sapiens
41 TCHP  
Two-hybrid Homo sapiens
42 PRPF18  
Two-hybrid Homo sapiens
43 ZNF581  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 Coro1c 23790
Affinity Capture-MS Mus musculus
45 PAK7  
Two-hybrid Homo sapiens
46 UTP14C  
Two-hybrid Homo sapiens
47 MPDZ  
Affinity Capture-MS Homo sapiens
48 TEAD4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 CD3EAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 HLA-DPB1 3115
Two-hybrid Homo sapiens
51 ARHGAP32  
Two-hybrid Homo sapiens
52 ABT1 29777
Two-hybrid Homo sapiens
53 RHNO1  
Two-hybrid Homo sapiens
54 MAGEB4  
Two-hybrid Homo sapiens
55 ACAD11 84129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 C19orf66  
Two-hybrid Homo sapiens
57 ZNF250  
Two-hybrid Homo sapiens
58 SH3RF2  
Two-hybrid Homo sapiens
59 GADD45GIP1  
Two-hybrid Homo sapiens
60 SBF1 6305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 NIP7 51388
Two-hybrid Homo sapiens
62 WT1-AS  
Two-hybrid Homo sapiens
63 RAD51D  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 GPANK1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
65 Cep72  
Affinity Capture-MS Mus musculus
66 Uso1 56041
Affinity Capture-MS Mus musculus
67 TRAF5  
Affinity Capture-MS Homo sapiens
68 Cep78  
Affinity Capture-MS Mus musculus
69 RHPN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 CTNNA1 1495
Proximity Label-MS Homo sapiens
71 PRKAB2 5565
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
72 KRT19 3880
Proximity Label-MS Homo sapiens
73 C8orf33 65265
Two-hybrid Homo sapiens
74 EAPP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 GRB2 2885
Two-hybrid Homo sapiens
76 WWOX 51741
Affinity Capture-MS Homo sapiens
77 TCEB3 6924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 LCK 3932
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
79 MORF4L2  
Two-hybrid Homo sapiens
80 MTA1 9112
Two-hybrid Homo sapiens
81 CWF19L2  
Two-hybrid Homo sapiens
82 LATS1  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
83 PSMA1 5682
Two-hybrid Homo sapiens
84 ERCC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 CHIC2 26511
Two-hybrid Homo sapiens
86 FAM221B  
Two-hybrid Homo sapiens
87 HM13 81502
Two-hybrid Homo sapiens
88 HIC2 23119
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 CEP135  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
90 TTLL10 254173
Two-hybrid Homo sapiens
91 DUSP4 1846
Two-hybrid Homo sapiens
92 SNW1 22938
Two-hybrid Homo sapiens
93 CLIP4  
Two-hybrid Homo sapiens
94 MIS18BP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 RANGAP1 5905
Affinity Capture-MS Homo sapiens
96 KIF9 64147
Two-hybrid Homo sapiens
97 NUDT15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 FRG1 2483
Two-hybrid Homo sapiens
99 PTPN22  
Proximity Label-MS Homo sapiens
100 GJA1 2697
Proximity Label-MS Homo sapiens
101 SCNM1  
Two-hybrid Homo sapiens
102 APC  
Affinity Capture-MS Homo sapiens
103 GFAP 2670
Proximity Label-MS Homo sapiens
104 GMCL1P1  
Two-hybrid Homo sapiens
105 EYA2  
Proximity Label-MS Homo sapiens
106 TTC23  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
107 SRSF2 6427
Two-hybrid Homo sapiens
108 SPG7  
Two-hybrid Homo sapiens
109 LZTS3  
Affinity Capture-MS Homo sapiens
110 HOXB9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
111 TTLL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 SASS6 163786
Proximity Label-MS Homo sapiens
113 ZNF74  
Affinity Capture-MS Homo sapiens
114 CPSF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 RECQL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 C11orf52 91894
Proximity Label-MS Homo sapiens
117 PLCG1 5335
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 CABP5  
Two-hybrid Homo sapiens
119 ZNF644  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 PHF1  
Two-hybrid Homo sapiens
121 ARNT2  
Two-hybrid Homo sapiens
122 AMOT  
Proximity Label-MS Homo sapiens
123 DYRK1B  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 IQCE 23288
Two-hybrid Homo sapiens
125 AGAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 RNF41  
Two-hybrid Homo sapiens
127 TPR 7175
Affinity Capture-MS Homo sapiens
128 RNF32  
Two-hybrid Homo sapiens
129 CDKN1A  
Two-hybrid Homo sapiens
130 LYN 4067
Proximity Label-MS Homo sapiens
131 NBN 4683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 ZMYM1 79830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 CTC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 NCAPD3 23310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 SIPA1L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 RIN1 9610
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
137 C20orf195  
Two-hybrid Homo sapiens
138 THAP10  
Two-hybrid Homo sapiens
139 TXNL4A 10907
Two-hybrid Homo sapiens
140 MRM1  
Affinity Capture-MS Homo sapiens
141 CCNC  
Two-hybrid Homo sapiens
142 XPO1 7514
Affinity Capture-MS Homo sapiens
143 NCBP2 22916
Two-hybrid Homo sapiens
144 FAM50B  
Two-hybrid Homo sapiens
145 NCAPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 RAB11A 8766
Proximity Label-MS Homo sapiens
147 FGF12  
Two-hybrid Homo sapiens
148 PRKAA2 5563
Two-hybrid Homo sapiens
149 WDR33 55339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 FAM90A1  
Two-hybrid Homo sapiens
151 TSSC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 MORF4L1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
153 KAZN  
Two-hybrid Homo sapiens
154 CEP250 11190
Affinity Capture-MS Homo sapiens
155 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 ZMYM6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 UBASH3A 53347
Two-hybrid Homo sapiens
158 PKP4 8502
Two-hybrid Homo sapiens
159 GLYCTK  
Two-hybrid Homo sapiens
160 SESTD1 91404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 RHOB 388
Proximity Label-MS Homo sapiens
162 NCAPG2 54892
Affinity Capture-MS Homo sapiens
163 SLU7  
Two-hybrid Homo sapiens
164 SNHG11  
Two-hybrid Homo sapiens
165 FRMD6 122786
Two-hybrid Homo sapiens
166 HUWE1 10075
Affinity Capture-MS Homo sapiens
167 RNF43  
Proximity Label-MS Homo sapiens
168 CEP290  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 TRAF2 7186
Two-hybrid Homo sapiens
171 NEK6 10783
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
172 Myo1c 17913
Affinity Capture-MS Mus musculus
173 SIPA1L3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
175 FAM184A 79632
Proximity Label-MS Homo sapiens
176 TROAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 PHF19  
Two-hybrid Homo sapiens
178 ZNF490  
Two-hybrid Homo sapiens
179 ABI2 10152
Two-hybrid Homo sapiens
180 C2CD5 9847
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 KRAS 3845
Proximity Label-MS Homo sapiens
182 SH3KBP1 30011
Two-hybrid Homo sapiens
183 LMO1  
Two-hybrid Homo sapiens
184 MYO18A 399687
Affinity Capture-MS Homo sapiens
185 GATA1  
Two-hybrid Homo sapiens
186 BAHD1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
187 MORN3  
Two-hybrid Homo sapiens
188 OCLN 100506658
Proximity Label-MS Homo sapiens
189 PARD3 56288
Proximity Label-MS Homo sapiens
190 CATSPER1  
Two-hybrid Homo sapiens
191 ISCA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 BYSL 705
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
193 STX4 6810
Proximity Label-MS Homo sapiens
194 ZNF414  
Affinity Capture-MS Homo sapiens
195 ZMAT2  
Two-hybrid Homo sapiens
196 MLLT4 4301
Proximity Label-MS Homo sapiens
197 CEP57L1  
Two-hybrid Homo sapiens
198 SOGA1 140710
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 LASP1 3927
Two-hybrid Homo sapiens
200 SUPV3L1 6832
Two-hybrid Homo sapiens
201 IQGAP1 8826
Affinity Capture-MS Homo sapiens
202 SUV39H1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
203 BRPF3  
Affinity Capture-MS Homo sapiens
204 POLR1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 DUSP5  
Affinity Capture-MS Homo sapiens
206 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 USF2 7392
Two-hybrid Homo sapiens
208 ZNF20  
Two-hybrid Homo sapiens
209 CEP131 22994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 VEZF1  
Two-hybrid Homo sapiens
211 SPATA24  
Two-hybrid Homo sapiens
212 CDC23 8697
Two-hybrid Homo sapiens
213 FKBP6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
214 CXADR 1525
Proximity Label-MS Homo sapiens
215 CHCHD3 54927
Two-hybrid Homo sapiens
216 TCEA2  
Two-hybrid Homo sapiens
217 TRIM42  
Two-hybrid Homo sapiens
218 KIAA1683  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
219 GTF2H1 2965
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 TSSK3  
Two-hybrid Homo sapiens
221 DIRAS3  
Proximity Label-MS Homo sapiens
222 ZNF324  
Affinity Capture-MS Homo sapiens
223 FAM103A1  
Two-hybrid Homo sapiens
224 UNC119 9094
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
225 PIK3R1 5295
Affinity Capture-Western Homo sapiens
226 MEMO1 51072
Two-hybrid Homo sapiens
227 BMX  
Affinity Capture-MS Homo sapiens
228 LATS2 26524
Proximity Label-MS Homo sapiens
229 FGF4  
Affinity Capture-MS Homo sapiens
230 STAC  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
231 ASPM 259266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
232 ZNF572  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
233 RBFOX1 54715
Two-hybrid Homo sapiens