Gene description for LZTS2
Gene name leucine zipper, putative tumor suppressor 2
Gene symbol LZTS2
Other names/aliases LAPSER1
Species Homo sapiens
 Database cross references - LZTS2
ExoCarta ExoCarta_84445
Entrez Gene 84445
HGNC 29381
MIM 610454
UniProt Q9BRK4  
 LZTS2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for LZTS2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    mitotic nuclear division GO:0007067 IEA
    negative regulation of cell proliferation GO:0008285 IEA
    kidney development GO:0001822 IEA
    nuclear export GO:0051168 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IEA
    spindle midzone assembly GO:0051255 IEA
    cytokinesis GO:0000910 IEA
    Wnt signaling pathway GO:0016055 IEA
    microtubule severing GO:0051013 IEA
    negative regulation of protein localization to nucleus GO:1900181 IEA
Subcellular Localization
    midbody GO:0030496 IEA
    microtubule GO:0005874 IEA
    centrosome GO:0005813 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified LZTS2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LZTS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DIPA  
Two-hybrid Homo sapiens
2 TRIM29  
Two-hybrid Homo sapiens
3 KIAA0980  
Two-hybrid Homo sapiens
4 ZNF581  
Two-hybrid Homo sapiens
5 PAK7  
Two-hybrid Homo sapiens
6 TRAF2  
Two-hybrid Homo sapiens
7 RBPMS  
Two-hybrid Homo sapiens
8 PEPP-2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LZTS2 is involved
No pathways found





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