Gene description for GIPC2
Gene name GIPC PDZ domain containing family, member 2
Gene symbol GIPC2
Other names/aliases SEMCAP-2
SEMCAP2
Species Homo sapiens
 Database cross references - GIPC2
ExoCarta ExoCarta_54810
Vesiclepedia VP_54810
Entrez Gene 54810
HGNC 18177
UniProt Q8TF65  
 GIPC2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for GIPC2
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified GIPC2 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GIPC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COL6A1 1291
Co-fractionation Homo sapiens
2 INADL 10207
Two-hybrid Homo sapiens
3 PTN  
Two-hybrid Homo sapiens
4 GIPC1 10755
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 IRF4  
Two-hybrid Homo sapiens
6 APPL1 26060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SH3BP4 23677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CTRC  
Two-hybrid Homo sapiens
9 ZBTB26  
Two-hybrid Homo sapiens
10 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
11 PLEKHA2 59339
Two-hybrid Homo sapiens
12 ZCCHC7  
Two-hybrid Homo sapiens
13 SETDB1  
Two-hybrid Homo sapiens
14 GIPC2 54810
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 PSMD14 10213
Affinity Capture-MS Homo sapiens
16 COL1A1 1277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 LZTS2 84445
Two-hybrid Homo sapiens
18 UBE2I 7329
Two-hybrid Homo sapiens
19 IGSF21  
Two-hybrid Homo sapiens
20 UNC119 9094
Two-hybrid Homo sapiens
21 ARHGEF12 23365
Proximity Label-MS Homo sapiens
22 SEMA4C 54910
Affinity Capture-MS Homo sapiens
23 SP100 6672
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GIPC2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here