Gene description for SEMA4C
Gene name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Gene symbol SEMA4C
Other names/aliases M-SEMA-F
Species Homo sapiens
 Database cross references - SEMA4C
ExoCarta ExoCarta_54910
Entrez Gene 54910
HGNC 10731
MIM 604462
UniProt Q9C0C4  
 SEMA4C identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for SEMA4C
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    semaphorin-plexin signaling pathway GO:0071526 ISS
    muscle cell differentiation GO:0042692 IDA
    neural tube closure GO:0001843 ISS
    cell migration in hindbrain GO:0021535 ISS
    positive regulation of stress-activated MAPK cascade GO:0032874 IDA
    cerebellum development GO:0021549 IEA
Subcellular Localization
    postsynaptic density GO:0014069 ISS
    extracellular space GO:0005615 IDA
    postsynaptic membrane GO:0045211 IEA
    cell junction GO:0030054 IEA
    integral component of membrane GO:0016021 IEA
    synaptic vesicle membrane GO:0030672 ISS
 Experiment description of studies that identified SEMA4C in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for SEMA4C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DLG4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 DLG3 1741
Two-hybrid Homo sapiens
3 GIPC1 10755
Invivo Homo sapiens
Invitro Homo sapiens
4 DLG2 1740
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SEMA4C is involved
No pathways found

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