Gene description for VPS18
Gene name vacuolar protein sorting 18 homolog (S. cerevisiae)
Gene symbol VPS18
Other names/aliases PEP3
Species Homo sapiens
 Database cross references - VPS18
ExoCarta ExoCarta_57617
Entrez Gene 57617
HGNC 15972
MIM 608551
UniProt Q9P253  
 VPS18 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for VPS18
Molecular Function
    syntaxin binding GO:0019905 IDA
    protein binding, bridging GO:0030674 IBA
    protein binding GO:0005515 IPI
    actin binding GO:0003779 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    endosome organization GO:0007032 IDA
    intracellular protein transport GO:0006886 IEA
    regulation of SNARE complex assembly GO:0035542 IBA
    lysosome organization GO:0007040 IDA
    vesicle docking involved in exocytosis GO:0006904 IBA
    viral entry into host cell GO:0046718 IEA
Subcellular Localization
    early endosome GO:0005769 IEA
    lysosomal membrane GO:0005765 IDA
    lysosome GO:0005764 IDA
    HOPS complex GO:0030897 IDA
    late endosome GO:0005770 IDA
    late endosome membrane GO:0031902 IEA
    actin filament GO:0005884 IEA
 Experiment description of studies that identified VPS18 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VPS18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VPS33A 65082
Invivo Homo sapiens
Invivo Homo sapiens
2 CCNA1  
Affinity Capture-MS Homo sapiens
3 STX7 8417
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
4 VPS16 64601
Invivo Homo sapiens
Invivo Homo sapiens
5 VPS18 57617
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
6 VPS11 55823
Invivo Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which VPS18 is involved
No pathways found





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