Gene description for TGFBRAP1
Gene name transforming growth factor, beta receptor associated protein 1
Gene symbol TGFBRAP1
Other names/aliases TRAP-1
TRAP1
Species Homo sapiens
 Database cross references - TGFBRAP1
ExoCarta ExoCarta_9392
Vesiclepedia VP_9392
Entrez Gene 9392
HGNC 16836
MIM 606237
UniProt Q8WUH2  
 TGFBRAP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for TGFBRAP1
Molecular Function
    transforming growth factor beta receptor binding GO:0005160 IDA
    protein binding GO:0005515 IPI
    SMAD binding GO:0046332 IDA
Biological Process
    regulation of DNA-templated transcription GO:0006355 IDA
    intracellular protein transport GO:0006886 IEA
    autophagy GO:0006914 IBA
    signal transduction GO:0007165 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    endosome to lysosome transport GO:0008333 IMP
    endosomal vesicle fusion GO:0034058 IBA
    endosomal vesicle fusion GO:0034058 IMP
    endosomal vesicle fusion GO:0034058 NAS
    regulation of SNARE complex assembly GO:0035542 NAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    early endosome GO:0005769 IDA
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    CORVET complex GO:0033263 NAS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified TGFBRAP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TGFBRAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VPS16 64601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 VPS41 27072
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 C22orf29  
Affinity Capture-MS Homo sapiens
4 RPL32 6161
Affinity Capture-MS Homo sapiens
5 EFNA4  
Affinity Capture-MS Homo sapiens
6 PSMD14 10213
Affinity Capture-MS Homo sapiens
7 SCYL3 57147
Affinity Capture-MS Homo sapiens
8 C15orf27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SYCE1  
Affinity Capture-MS Homo sapiens
10 ORAOV1  
Affinity Capture-MS Homo sapiens
11 S100A6 6277
Affinity Capture-MS Homo sapiens
12 ISOC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MID1IP1  
Affinity Capture-MS Homo sapiens
14 ATG9A 79065
Proximity Label-MS Homo sapiens
15 SMAD4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
16 VSIG8  
Affinity Capture-MS Homo sapiens
17 CSTA 1475
Affinity Capture-MS Homo sapiens
18 RNF7  
Affinity Capture-MS Homo sapiens
19 ACVR1 90
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 VPS33A 65082
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 UVRAG  
Affinity Capture-MS Homo sapiens
22 LRRC25  
Affinity Capture-MS Homo sapiens
23 RNF38  
Affinity Capture-MS Homo sapiens
24 CCDC110  
Affinity Capture-MS Homo sapiens
25 C3orf18  
Affinity Capture-MS Homo sapiens
26 ZFHX3  
Affinity Capture-MS Homo sapiens
27 LRRC61 65999
Affinity Capture-MS Homo sapiens
28 WHAMMP3  
Affinity Capture-MS Homo sapiens
29 NRBF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TTC9C 283237
Affinity Capture-MS Homo sapiens
31 DYDC2  
Affinity Capture-MS Homo sapiens
32 VPS11 55823
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CROCC 9696
Affinity Capture-MS Homo sapiens
34 Vps41  
Affinity Capture-MS Mus musculus
35 C7orf60 154743
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SEMA4C 54910
Affinity Capture-MS Homo sapiens
37 ALOX5  
Two-hybrid Homo sapiens
38 VPS8 23355
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 THRSP  
Affinity Capture-MS Homo sapiens
40 VPS18 57617
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TICAM1  
Affinity Capture-MS Homo sapiens
42 ARFGAP1 55738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TGFBRAP1 is involved
No pathways found





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