Gene description for LRRC61
Gene name leucine rich repeat containing 61
Gene symbol LRRC61
Other names/aliases HSPC295
Species Homo sapiens
 Database cross references - LRRC61
ExoCarta ExoCarta_65999
Vesiclepedia VP_65999
Entrez Gene 65999
HGNC 21704
UniProt Q9BV99  
 LRRC61 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for LRRC61
Molecular Function
    protein binding GO:0005515 IPI
    alpha-tubulin binding GO:0043014 IBA
    dynein heavy chain binding GO:0045504 IBA
Biological Process
    outer dynein arm assembly GO:0036158 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified LRRC61 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LRRC61
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNX1 6642
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ENKD1  
Two-hybrid Homo sapiens
3 TNIP1 10318
Proximity Label-MS Homo sapiens
4 DNAJC27  
Affinity Capture-MS Homo sapiens
5 SNRPE 6635
Proximity Label-MS Homo sapiens
6 C1orf216  
Two-hybrid Homo sapiens
7 TGFBRAP1 9392
Affinity Capture-MS Homo sapiens
8 INPPL1 3636
Affinity Capture-MS Homo sapiens
9 FAM222B  
Two-hybrid Homo sapiens
10 RPAP1  
Proximity Label-MS Homo sapiens
11 POLD1 5424
Proximity Label-MS Homo sapiens
12 CARM1 10498
Affinity Capture-MS Homo sapiens
13 FAM184A 79632
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FKBP8 23770
Proximity Label-MS Homo sapiens
15 PLEKHA1 59338
Affinity Capture-MS Homo sapiens
16 NUDT19 390916
Proximity Label-MS Homo sapiens
17 KIAA1524 57650
Affinity Capture-MS Homo sapiens
18 SNX6 58533
Proximity Label-MS Homo sapiens
19 WRAP73 49856
Proximity Label-MS Homo sapiens
20 CDK5RAP2 55755
Proximity Label-MS Homo sapiens
21 PI4K2B 55300
Affinity Capture-MS Homo sapiens
22 TEX264 51368
Affinity Capture-MS Homo sapiens
23 MOV10 4343
Affinity Capture-RNA Homo sapiens
24 YME1L1 10730
Affinity Capture-MS Homo sapiens
25 VCL 7414
Proximity Label-MS Homo sapiens
26 SLC3A2 6520
Affinity Capture-MS Homo sapiens
27 NEDD1 121441
Affinity Capture-MS Homo sapiens
28 MGEA5 10724
Proximity Label-MS Homo sapiens
29 TLN1 7094
Proximity Label-MS Homo sapiens
30 TARS2 80222
Proximity Label-MS Homo sapiens
31 FLNC 2318
Affinity Capture-MS Homo sapiens
32 PKN1 5585
Two-hybrid Homo sapiens
33 HGS 9146
Two-hybrid Homo sapiens
34 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
35 CUX1 1523
Affinity Capture-MS Homo sapiens
36 SIK2  
Affinity Capture-MS Homo sapiens
37 SNX5 27131
Proximity Label-MS Homo sapiens
38 VPS11 55823
Affinity Capture-MS Homo sapiens
39 RABEP2 79874
Affinity Capture-MS Homo sapiens
40 TYK2 7297
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRC61 is involved
No pathways found





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