Gene description for PLEKHA1
Gene name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Gene symbol PLEKHA1
Other names/aliases TAPP1
Species Homo sapiens
 Database cross references - PLEKHA1
ExoCarta ExoCarta_59338
Entrez Gene 59338
HGNC 14335
MIM 607772
UniProt Q9HB21  
 PLEKHA1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PLEKHA1
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
    PDZ domain binding GO:0030165 IPI
Biological Process
    negative regulation of protein kinase B signaling GO:0051898 IMP
    luteinization GO:0001553 IEA
    palate development GO:0060021 IEA
    estrogen metabolic process GO:0008210 IEA
    phosphatidylinositol 3-kinase signaling GO:0014065 IDA
    multicellular organism growth GO:0035264 IEA
    skeletal system morphogenesis GO:0048705 IEA
    establishment of protein localization GO:0045184 IDA
    spermatogenesis GO:0007283 IEA
    post-embryonic development GO:0009791 IEA
    cellular response to hydrogen peroxide GO:0070301 IDA
    ruffle organization GO:0031529 IDA
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    androgen metabolic process GO:0008209 IEA
    B cell receptor signaling pathway GO:0050853 IDA
    Leydig cell differentiation GO:0033327 IEA
    face morphogenesis GO:0060325 IEA
Subcellular Localization
    ruffle membrane GO:0032587 IDA
    extracellular exosome GO:0070062 IDA
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PLEKHA1 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PLEKHA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPDZ  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PLEKHA1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here