Gene description for CXADR
Gene name coxsackie virus and adenovirus receptor
Gene symbol CXADR
Other names/aliases CAR
CAR4/6
HCAR
Species Homo sapiens
 Database cross references - CXADR
ExoCarta ExoCarta_1525
Vesiclepedia VP_1525
Entrez Gene 1525
HGNC 2559
MIM 602621
UniProt P78310  
 CXADR identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CXADR
Molecular Function
    virus receptor activity GO:0001618 IEA
    signaling receptor binding GO:0005102 IPI
    integrin binding GO:0005178 IPI
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    PDZ domain binding GO:0030165 IPI
    identical protein binding GO:0042802 IDA
    cell adhesion molecule binding GO:0050839 IBA
    cell adhesion molecule binding GO:0050839 IPI
    connexin binding GO:0071253 ISS
    cell adhesive protein binding involved in AV node cell-bundle of His cell communication GO:0086082 IC
Biological Process
    mitochondrion organization GO:0007005 ISS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA
    heart development GO:0007507 ISS
    germ cell migration GO:0008354 ISS
    epithelial structure maintenance GO:0010669 IMP
    actin cytoskeleton organization GO:0030036 IDA
    neutrophil chemotaxis GO:0030593 IMP
    homotypic cell-cell adhesion GO:0034109 IBA
    homotypic cell-cell adhesion GO:0034109 IDA
    cell-cell junction organization GO:0045216 ISS
    gamma-delta T cell activation GO:0046629 ISS
    symbiont entry into host cell GO:0046718 IEA
    defense response to virus GO:0051607 IDA
    cardiac muscle cell development GO:0055013 ISS
    transepithelial transport GO:0070633 IMP
    AV node cell to bundle of His cell communication GO:0086067 ISS
    AV node cell-bundle of His cell adhesion involved in cell communication GO:0086072 ISS
    regulation of AV node cell action potential GO:0098904 ISS
Subcellular Localization
    acrosomal vesicle GO:0001669 ISS
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 HDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IDA
    adherens junction GO:0005912 IDA
    bicellular tight junction GO:0005923 IBA
    bicellular tight junction GO:0005923 IDA
    intercalated disc GO:0014704 IBA
    intercalated disc GO:0014704 IDA
    basolateral plasma membrane GO:0016323 IBA
    basolateral plasma membrane GO:0016323 IDA
    apicolateral plasma membrane GO:0016327 IDA
    cell junction GO:0030054 IDA
    filopodium GO:0030175 ISS
    growth cone GO:0030426 ISS
    neuromuscular junction GO:0031594 IDA
    protein-containing complex GO:0032991 IDA
    neuron projection GO:0043005 ISS
    cell body GO:0044297 ISS
    membrane raft GO:0045121 IDA
 Experiment description of studies that identified CXADR in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
9
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
21
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
22
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CXADR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 ITGB1 3688
Proximity Label-MS Homo sapiens
3 ACSL3 2181
Proximity Label-MS Homo sapiens
4 KIF14 9928
Proximity Label-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 ARHGAP1 392
Proximity Label-MS Homo sapiens
7 USP6NL 9712
Proximity Label-MS Homo sapiens
8 TMEM199  
Proximity Label-MS Homo sapiens
9 ANKLE2 23141
Proximity Label-MS Homo sapiens
10 ZDHHC5 25921
Proximity Label-MS Homo sapiens
11 SIPA1L3  
Proximity Label-MS Homo sapiens
12 KIF16B 55614
Proximity Label-MS Homo sapiens
13 OCLN 100506658
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
14 CEP89 84902
Proximity Label-MS Homo sapiens
15 VAPA 9218
Proximity Label-MS Homo sapiens
16 MARCKS 4082
Proximity Label-MS Homo sapiens
17 LAMP3  
Proximity Label-MS Homo sapiens
18 LLGL1 3996
Proximity Label-MS Homo sapiens
19 GJA1 2697
Proximity Label-MS Homo sapiens
20 PKP2 5318
Proximity Label-MS Homo sapiens
21 EFR3A 23167
Proximity Label-MS Homo sapiens
22 PARD3 56288
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
23 CRK 1398
Proximity Label-MS Homo sapiens
24 JPH1 56704
Proximity Label-MS Homo sapiens
25 EPB41L5 57669
Proximity Label-MS Homo sapiens
26 RASAL2 9462
Proximity Label-MS Homo sapiens
27 PTPN13 5783
Proximity Label-MS Homo sapiens
28 ADGRL2 23266
Proximity Label-MS Homo sapiens
29 SRPR 6734
Proximity Label-MS Homo sapiens
30 ARF3 377
Proximity Label-MS Homo sapiens
31 STIM2 57620
Proximity Label-MS Homo sapiens
32 ADD3 120
Proximity Label-MS Homo sapiens
33 SHB 6461
Proximity Label-MS Homo sapiens
34 CNP 1267
Proximity Label-MS Homo sapiens
35 LAMP2 3920
Proximity Label-MS Homo sapiens
36 SYNE2 23224
Proximity Label-MS Homo sapiens
37 BASP1 10409
Proximity Label-MS Homo sapiens
38 GRAMD1A  
Proximity Label-MS Homo sapiens
39 WDR6 11180
Proximity Label-MS Homo sapiens
40 PDE3B  
Proximity Label-MS Homo sapiens
41 APBB1  
Proximity Label-MS Homo sapiens
42 PLCH1  
Proximity Label-MS Homo sapiens
43 STX4 6810
Proximity Label-MS Homo sapiens
44 PALM2  
Proximity Label-MS Homo sapiens
45 SNX6 58533
Proximity Label-MS Homo sapiens
46 RASA3 22821
Proximity Label-MS Homo sapiens
47 MAL  
Two-hybrid Homo sapiens
48 MARVELD2 153562
Proximity Label-MS Homo sapiens
49 GRHPR 9380
Co-fractionation Homo sapiens
50 YES1 7525
Proximity Label-MS Homo sapiens
51 POTEE 445582
Proximity Label-MS Homo sapiens
52 VANGL2  
Proximity Label-MS Homo sapiens
53 SNAP23 8773
Proximity Label-MS Homo sapiens
54 TEX264 51368
Proximity Label-MS Homo sapiens
55 MARK2 2011
Proximity Label-MS Homo sapiens
56 RASSF8 11228
Proximity Label-MS Homo sapiens
57 MLLT4 4301
Proximity Label-MS Homo sapiens
58 WDR41  
Proximity Label-MS Homo sapiens
59 KIAA1462 57608
Proximity Label-MS Homo sapiens
60 FAM171A2 284069
Proximity Label-MS Homo sapiens
61 CPD 1362
Proximity Label-MS Homo sapiens
62 APBB2  
Proximity Label-MS Homo sapiens
63 GOLGA3 2802
Proximity Label-MS Homo sapiens
64 NUMBL 9253
Proximity Label-MS Homo sapiens
65 SMPD4 55627
Proximity Label-MS Homo sapiens
66 DZIP1  
Proximity Label-MS Homo sapiens
67 RAB3B 5865
Proximity Label-MS Homo sapiens
68 VKORC1 79001
Two-hybrid Homo sapiens
69 DSC2 1824
Proximity Label-MS Homo sapiens
70 TNIK 23043
Proximity Label-MS Homo sapiens
71 ARF1 375
Proximity Label-MS Homo sapiens
72 MAP4K5 11183
Proximity Label-MS Homo sapiens
73 STBD1 8987
Proximity Label-MS Homo sapiens
74 WDR7 23335
Proximity Label-MS Homo sapiens
75 C11orf52 91894
Proximity Label-MS Homo sapiens
76 ARHGEF10 9639
Proximity Label-MS Homo sapiens
77 STEAP3 55240
Proximity Label-MS Homo sapiens
78 SCFD1 23256
Proximity Label-MS Homo sapiens
79 PGRMC2 10424
Proximity Label-MS Homo sapiens
80 DHCR7 1717
Proximity Label-MS Homo sapiens
81 CD99 4267
Proximity Label-MS Homo sapiens
82 FAM135A  
Proximity Label-MS Homo sapiens
83 STX6 10228
Proximity Label-MS Homo sapiens
84 CCDC47 57003
Proximity Label-MS Homo sapiens
85 PTPN14 5784
Proximity Label-MS Homo sapiens
86 SLC1A5 6510
Proximity Label-MS Homo sapiens
87 RAB11FIP1 80223
Proximity Label-MS Homo sapiens
88 FGD6  
Proximity Label-MS Homo sapiens
89 PALM 5064
Proximity Label-MS Homo sapiens
90 PSMC1 5700
Proximity Label-MS Homo sapiens
91 RAB35 11021
Proximity Label-MS Homo sapiens
92 SNX9 51429
Proximity Label-MS Homo sapiens
93 ESYT2 57488
Proximity Label-MS Homo sapiens
94 SCRIB 23513
Proximity Label-MS Homo sapiens
95 FAF2 23197
Proximity Label-MS Homo sapiens
96 EBAG9 9166
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
97 SMCR8 140775
Proximity Label-MS Homo sapiens
98 GPRIN1 114787
Proximity Label-MS Homo sapiens
99 TMEM87A 25963
Proximity Label-MS Homo sapiens
100 KIAA1804  
Proximity Label-MS Homo sapiens
101 LAMTOR1 55004
Proximity Label-MS Homo sapiens
102 PPP1R16B  
Proximity Label-MS Homo sapiens
103 NOTCH2 4853
Proximity Label-MS Homo sapiens
104 EWSR1 2130
Two-hybrid Homo sapiens
105 CAMLG 819
Proximity Label-MS Homo sapiens
106 LMAN1 3998
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
107 PAK4 10298
Proximity Label-MS Homo sapiens
108 NUP155 9631
Proximity Label-MS Homo sapiens
109 SLC30A1 7779
Proximity Label-MS Homo sapiens
110 LRRC59 55379
Proximity Label-MS Homo sapiens
111 NF2 4771
Proximity Label-MS Homo sapiens
112 HLA-A 3105
Proximity Label-MS Homo sapiens
113 IRS4 8471
Proximity Label-MS Homo sapiens
114 LMNB1 4001
Proximity Label-MS Homo sapiens
115 CYP2S1  
Affinity Capture-MS Homo sapiens
116 SENP2 59343
Proximity Label-MS Homo sapiens
117 EFNB2 1948
Proximity Label-MS Homo sapiens
118 ADD1 118
Proximity Label-MS Homo sapiens
119 EMD 2010
Proximity Label-MS Homo sapiens
120 ZFYVE9  
Proximity Label-MS Homo sapiens
121 SH3BP4 23677
Proximity Label-MS Homo sapiens
122 SORBS1 10580
Proximity Label-MS Homo sapiens
123 XPO1 7514
Proximity Label-MS Homo sapiens
124 DRG1 4733
Proximity Label-MS Homo sapiens
125 LYN 4067
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
126 MCAM 4162
Proximity Label-MS Homo sapiens
127 EFR3B  
Proximity Label-MS Homo sapiens
128 RAB4A 5867
Proximity Label-MS Homo sapiens
129 SNAP47 116841
Proximity Label-MS Homo sapiens
130 SCAMP1 9522
Proximity Label-MS Homo sapiens
131 ANKS6 203286
Proximity Label-MS Homo sapiens
132 PDXDC1 23042
Proximity Label-MS Homo sapiens
133 DNAJC5 80331
Proximity Label-MS Homo sapiens
134 ADD2 119
Proximity Label-MS Homo sapiens
135 MB21D2  
Proximity Label-MS Homo sapiens
136 CDKAL1  
Proximity Label-MS Homo sapiens
137 CDH1 999
Proximity Label-MS Homo sapiens
138 CYB5A 1528
Proximity Label-MS Homo sapiens
139 CLCC1 23155
Proximity Label-MS Homo sapiens
140 NUMB 8650
Proximity Label-MS Homo sapiens
141 DIRAS3  
Proximity Label-MS Homo sapiens
142 SPRY4 81848
Proximity Label-MS Homo sapiens
143 RELL1 768211
Proximity Label-MS Homo sapiens
144 OGT 8473
Reconstituted Complex Homo sapiens
145 GORASP2 26003
Proximity Label-MS Homo sapiens
146 HIST1H1E 3008
Proximity Label-MS Homo sapiens
147 FERMT2 10979
Proximity Label-MS Homo sapiens
148 GOPC 57120
Proximity Label-MS Homo sapiens
149 TACC1 6867
Proximity Label-MS Homo sapiens
150 TBC1D10B 26000
Proximity Label-MS Homo sapiens
151 PREB 10113
Proximity Label-MS Homo sapiens
152 PIK3R1 5295
Proximity Label-MS Homo sapiens
153 STX5 6811
Proximity Label-MS Homo sapiens
154 ARL13B 200894
Proximity Label-MS Homo sapiens
155 MPP7 143098
Proximity Label-MS Homo sapiens
156 DLG1 1739
Proximity Label-MS Homo sapiens
157 FLOT2 2319
Proximity Label-MS Homo sapiens
158 ANKRD26 22852
Proximity Label-MS Homo sapiens
159 CTDSPL 10217
Proximity Label-MS Homo sapiens
160 SLC30A6 55676
Proximity Label-MS Homo sapiens
161 NDC1 55706
Proximity Label-MS Homo sapiens
162 UBXN6 80700
Proximity Label-MS Homo sapiens
163 ACBD3 64746
Proximity Label-MS Homo sapiens
164 TMEM185A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 SLC4A7 9497
Proximity Label-MS Homo sapiens
166 DST 667
Proximity Label-MS Homo sapiens
167 SEC63 11231
Proximity Label-MS Homo sapiens
168 FGD1  
Proximity Label-MS Homo sapiens
169 EPB41L1 2036
Proximity Label-MS Homo sapiens
170 DIP2B 57609
Proximity Label-MS Homo sapiens
171 SEC24B 10427
Proximity Label-MS Homo sapiens
172 ARHGAP32  
Proximity Label-MS Homo sapiens
173 FAM83B  
Proximity Label-MS Homo sapiens
174 FAM129B 64855
Proximity Label-MS Homo sapiens
175 VAPB 9217
Proximity Label-MS Homo sapiens
176 CANX 821
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
177 SLC12A2 6558
Proximity Label-MS Homo sapiens
178 RAB5A 5868
Proximity Label-MS Homo sapiens
179 CDCA3 83461
Proximity Label-MS Homo sapiens
180 NBEA  
Proximity Label-MS Homo sapiens
181 SLC39A6 25800
Proximity Label-MS Homo sapiens
182 ATP2B1 490
Proximity Label-MS Homo sapiens
183 ADCY9 115
Proximity Label-MS Homo sapiens
184 ERBB2IP 55914
Proximity Label-MS Homo sapiens
185 HMOX2 3163
Proximity Label-MS Homo sapiens
186 LAMP1 3916
Proximity Label-MS Homo sapiens
187 CDC42EP1 11135
Proximity Label-MS Homo sapiens
188 FAM171A1 221061
Proximity Label-MS Homo sapiens
189 NEBL 10529
Proximity Label-MS Homo sapiens
190 TJP1 7082
Proximity Label-MS Homo sapiens
191 MAP4K4 9448
Proximity Label-MS Homo sapiens
192 RICTOR 253260
Proximity Label-MS Homo sapiens
193 STIM1 6786
Proximity Label-MS Homo sapiens
194 USP54 159195
Proximity Label-MS Homo sapiens
195 EGFR 1956
Proximity Label-MS Homo sapiens
196 C1orf21  
Proximity Label-MS Homo sapiens
197 SLC7A5 8140
Proximity Label-MS Homo sapiens
198 ARF6 382
Proximity Label-MS Homo sapiens
199 KCNB2  
Proximity Label-MS Homo sapiens
200 VAMP2 6844
Proximity Label-MS Homo sapiens
201 GAB1  
Proximity Label-MS Homo sapiens
202 PLEKHA5 54477
Proximity Label-MS Homo sapiens
203 LZTS2 84445
Proximity Label-MS Homo sapiens
204 CDC42BPA 8476
Proximity Label-MS Homo sapiens
205 KIRREL 55243
Proximity Label-MS Homo sapiens
206 FTSJ1 24140
Proximity Label-MS Homo sapiens
207 TJP2 9414
Proximity Label-MS Homo sapiens
208 RPA3 6119
Proximity Label-MS Homo sapiens
209 SLC3A2 6520
Proximity Label-MS Homo sapiens
210 PTPN1 5770
Proximity Label-MS Homo sapiens
211 PKP4 8502
Proximity Label-MS Homo sapiens
212 RAB9A 9367
Proximity Label-MS Homo sapiens
213 MPZL1 9019
Proximity Label-MS Homo sapiens
214 SH3D19 152503
Proximity Label-MS Homo sapiens
215 SLC6A15 55117
Proximity Label-MS Homo sapiens
216 PPFIBP1 8496
Proximity Label-MS Homo sapiens
217 PEAK1 79834
Proximity Label-MS Homo sapiens
218 FNDC3A 22862
Proximity Label-MS Homo sapiens
219 AMOT 154796
Proximity Label-MS Homo sapiens
220 DDRGK1 65992
Proximity Label-MS Homo sapiens
221 RHOB 388
Proximity Label-MS Homo sapiens
222 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
223 CCDC88A 55704
Proximity Label-MS Homo sapiens
224 TRIP11 9321
Proximity Label-MS Homo sapiens
225 LEMD3  
Proximity Label-MS Homo sapiens
226 CPNE8 144402
Proximity Label-MS Homo sapiens
227 OSBPL8 114882
Proximity Label-MS Homo sapiens
228 BAIAP2 10458
Proximity Label-MS Homo sapiens
229 CASKIN2  
Proximity Label-MS Homo sapiens
230 FLOT1 10211
Proximity Label-MS Homo sapiens
231 FARP1 10160
Proximity Label-MS Homo sapiens
232 CCDC8  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
233 MON2 23041
Proximity Label-MS Homo sapiens
234 GOLGB1 2804
Proximity Label-MS Homo sapiens
235 STUB1 10273
Proximity Label-MS Homo sapiens
236 PIP5K1A 8394
Proximity Label-MS Homo sapiens
237 MARK3 4140
Proximity Label-MS Homo sapiens
238 DEPDC1B 55789
Proximity Label-MS Homo sapiens
239 SLC38A2 54407
Proximity Label-MS Homo sapiens
240 GPRIN3  
Proximity Label-MS Homo sapiens
241 KIAA1549  
Proximity Label-MS Homo sapiens
242 PVRL2 5819
Proximity Label-MS Homo sapiens
243 ALDH3A2 224
Proximity Label-MS Homo sapiens
244 SHISA2 387914
Proximity Label-MS Homo sapiens
245 TRIM13  
Proximity Label-MS Homo sapiens
246 EPB41L4B 54566
Proximity Label-MS Homo sapiens
247 TMEM57  
Proximity Label-MS Homo sapiens
248 UBXN4 23190
Proximity Label-MS Homo sapiens
249 RAB11FIP5 26056
Proximity Label-MS Homo sapiens
250 LNX2  
Two-hybrid Homo sapiens
251 VRK2 7444
Proximity Label-MS Homo sapiens
252 VAMP3 9341
Proximity Label-MS Homo sapiens
253 VPS13B  
Proximity Label-MS Homo sapiens
254 PPFIA1 8500
Proximity Label-MS Homo sapiens
255 PSD3 23362
Proximity Label-MS Homo sapiens
256 FAM171B  
Proximity Label-MS Homo sapiens
257 LSR 51599
Proximity Label-MS Homo sapiens
258 DNAJA2 10294
Proximity Label-MS Homo sapiens
259 CKB 1152
Proximity Label-MS Homo sapiens
260 FAM3C 10447
Two-hybrid Homo sapiens
261 LSG1  
Proximity Label-MS Homo sapiens
262 EFNB1 1947
Proximity Label-MS Homo sapiens
263 LATS2 26524
Proximity Label-MS Homo sapiens
264 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
265 PLEKHA1 59338
Proximity Label-MS Homo sapiens
266 NISCH 11188
Proximity Label-MS Homo sapiens
267 SEC24A 10802
Proximity Label-MS Homo sapiens
268 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
269 ATP2A2 488
Proximity Label-MS Homo sapiens
270 PLK1 5347
Proximity Label-MS Homo sapiens
271 ROR2 4920
Proximity Label-MS Homo sapiens
272 NCK2 8440
Proximity Label-MS Homo sapiens
273 PDZD8 118987
Proximity Label-MS Homo sapiens
274 RABL3 285282
Proximity Label-MS Homo sapiens
275 PPP1R9A  
Proximity Label-MS Homo sapiens
276 PPP1R13B  
Proximity Label-MS Homo sapiens
277 RAB2A 5862
Proximity Label-MS Homo sapiens
278 PHACTR4 65979
Proximity Label-MS Homo sapiens
279 INF2 64423
Proximity Label-MS Homo sapiens
280 KIAA0754  
Proximity Label-MS Homo sapiens
281 MARK1 4139
Proximity Label-MS Homo sapiens
282 ACOT1 641371
Co-fractionation Homo sapiens
283 FRS2 10818
Proximity Label-MS Homo sapiens
284 RAB7A 7879
Proximity Label-MS Homo sapiens
285 ATP1A1 476
Proximity Label-MS Homo sapiens
286 RAB11A 8766
Proximity Label-MS Homo sapiens
287 SLC6A8 6535
Proximity Label-MS Homo sapiens
288 YKT6 10652
Proximity Label-MS Homo sapiens
289 CDK5RAP3 80279
Proximity Label-MS Homo sapiens
290 EHBP1 23301
Proximity Label-MS Homo sapiens
291 EPHA2 1969
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
292 TULP3 7289
Proximity Label-MS Homo sapiens
293 PIK3R2 5296
Proximity Label-MS Homo sapiens
294 KRAS 3845
Proximity Label-MS Homo sapiens
295 RAB5C 5878
Proximity Label-MS Homo sapiens
296 DSG2 1829
Proximity Label-MS Homo sapiens
297 SLC33A1 9197
Proximity Label-MS Homo sapiens
298 COPB2 9276
Proximity Label-MS Homo sapiens
299 CKAP4 10970
Proximity Label-MS Homo sapiens
300 VANGL1 81839
Proximity Label-MS Homo sapiens
301 ANKRD46 157567
Two-hybrid Homo sapiens
302 MTMR1 8776
Proximity Label-MS Homo sapiens
303 MAGI1  
Proximity Label-MS Homo sapiens
304 CAV1 857
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
305 SCYL3 57147
Proximity Label-MS Homo sapiens
306 ESYT1 23344
Proximity Label-MS Homo sapiens
307 VEZT 55591
Proximity Label-MS Homo sapiens
308 LNX1  
Two-hybrid Homo sapiens
309 SNAP29 9342
Proximity Label-MS Homo sapiens
310 CTNND1 1500
Proximity Label-MS Homo sapiens
311 UBA52 7311
Proximity Label-MS Homo sapiens
312 NSDHL 50814
Proximity Label-MS Homo sapiens
313 LRRC1 55227
Proximity Label-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here