Gene description for SCYL3
Gene name SCY1-like 3 (S. cerevisiae)
Gene symbol SCYL3
Other names/aliases PACE-1
PACE1
Species Homo sapiens
 Database cross references - SCYL3
ExoCarta ExoCarta_57147
Vesiclepedia VP_57147
Entrez Gene 57147
HGNC 19285
MIM 608192
UniProt Q8IZE3  
 SCYL3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SCYL3
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    kinase activity GO:0016301 IDA
    identical protein binding GO:0042802 IEA
Biological Process
    inflammatory response GO:0006954 IEA
    protein localization GO:0008104 IEA
    cell migration GO:0016477 NAS
    spinal cord motor neuron differentiation GO:0021522 IEA
    neuron development GO:0048666 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    lamellipodium GO:0030027 IDA
 Experiment description of studies that identified SCYL3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SCYL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCDC115 84317
Affinity Capture-MS Homo sapiens
2 GABARAPL1 23710
Two-hybrid Homo sapiens
3 COPG2 26958
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 ZFPL1 7542
Affinity Capture-MS Homo sapiens
6 TXN2 25828
Two-hybrid Homo sapiens
7 COPZ1 22818
Affinity Capture-MS Homo sapiens
8 WDR45B 56270
Affinity Capture-MS Homo sapiens
9 EBAG9 9166
Proximity Label-MS Homo sapiens
10 VAPB 9217
Affinity Capture-MS Homo sapiens
11 OCLN 100506658
Proximity Label-MS Homo sapiens
12 LAMTOR1 55004
Proximity Label-MS Homo sapiens
13 METTL7A 25840
Proximity Label-MS Homo sapiens
14 RAB9A 9367
Proximity Label-MS Homo sapiens
15 RAB5A 5868
Proximity Label-MS Homo sapiens
16 TGFBRAP1 9392
Affinity Capture-MS Homo sapiens
17 GJA1 2697
Proximity Label-MS Homo sapiens
18 INPPL1 3636
Affinity Capture-MS Homo sapiens
19 NCAPH2  
Affinity Capture-MS Homo sapiens
20 RAB11A 8766
Proximity Label-MS Homo sapiens
21 TPTE  
Proximity Label-MS Homo sapiens
22 MTCH2 23788
Affinity Capture-MS Homo sapiens
23 HSD3B7 80270
Proximity Label-MS Homo sapiens
24 LHX8  
Two-hybrid Homo sapiens
25 ATG9A 79065
Proximity Label-MS Homo sapiens
26 RFX1  
Affinity Capture-MS Homo sapiens
27 SYAP1 94056
Affinity Capture-MS Homo sapiens
28 COPE 11316
Affinity Capture-MS Homo sapiens
29 HDAC11  
Affinity Capture-MS Homo sapiens
30 CXADR 1525
Proximity Label-MS Homo sapiens
31 JPH1 56704
Affinity Capture-MS Homo sapiens
32 COPA 1314
Affinity Capture-MS Homo sapiens
33 COPG1 22820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FHL2 2274
Affinity Capture-MS Homo sapiens
35 RAB4A 5867
Proximity Label-MS Homo sapiens
36 XPO1 7514
Affinity Capture-MS Homo sapiens
37 FARSB 10056
Affinity Capture-MS Homo sapiens
38 B3GAT1  
Proximity Label-MS Homo sapiens
39 RAP1B 5908
Affinity Capture-MS Homo sapiens
40 NCAPD3 23310
Affinity Capture-MS Homo sapiens
41 AURKA 6790
Affinity Capture-MS Homo sapiens
42 SRBD1  
Affinity Capture-MS Homo sapiens
43 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
44 RAB7A 7879
Proximity Label-MS Homo sapiens
45 TRMT2B  
Affinity Capture-MS Homo sapiens
46 ACTR3 10096
Proximity Label-MS Homo sapiens
47 GOLGA1  
Proximity Label-MS Homo sapiens
48 COPB2 9276
Affinity Capture-MS Homo sapiens
49 RAC3 5881
Affinity Capture-MS Homo sapiens
50 CYC1 1537
Affinity Capture-MS Homo sapiens
51 EZR 7430
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
52 MRPS17 51373
Affinity Capture-MS Homo sapiens
53 UTP6  
Affinity Capture-MS Homo sapiens
54 UQCRH 7388
Affinity Capture-MS Homo sapiens
55 CAV1 857
Proximity Label-MS Homo sapiens
56 ELOVL5 60481
Proximity Label-MS Homo sapiens
57 ARSF 416
Affinity Capture-MS Homo sapiens
58 TRAPPC10 7109
Affinity Capture-MS Homo sapiens
59 NMD3 51068
Affinity Capture-MS Homo sapiens
60 STX6 10228
Proximity Label-MS Homo sapiens
61 VPS11 55823
Affinity Capture-MS Homo sapiens
62 ATG7 10533
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SCYL3 is involved
No pathways found





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