Gene description for GABARAPL1
Gene name GABA(A) receptor-associated protein like 1
Gene symbol GABARAPL1
Other names/aliases APG8-LIKE
APG8L
ATG8
ATG8B
ATG8L
GEC1
Species Homo sapiens
 Database cross references - GABARAPL1
ExoCarta ExoCarta_23710
Vesiclepedia VP_23710
Entrez Gene 23710
HGNC 4068
MIM 607420
UniProt Q9H0R8  
 GABARAPL1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GABARAPL1
Molecular Function
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IDA
    phosphatidylethanolamine binding GO:0008429 IBA
    Tat protein binding GO:0030957 IPI
    ubiquitin protein ligase binding GO:0031625 IBA
    ubiquitin protein ligase binding GO:0031625 IPI
    beta-tubulin binding GO:0048487 ISS
    GABA receptor binding GO:0050811 IBA
    GABA receptor binding GO:0050811 ISS
Biological Process
    autophagosome assembly GO:0000045 IBA
    mitophagy GO:0000423 IBA
    cellular response to nitrogen starvation GO:0006995 IBA
    glycophagy GO:0061723 IEA
    autophagosome maturation GO:0097352 IBA
Subcellular Localization
    autophagosome membrane GO:0000421 IBA
    autophagosome membrane GO:0000421 TAS
    mitochondrion GO:0005739 IGI
    autophagosome GO:0005776 IDA
    endoplasmic reticulum GO:0005783 IEA
    Golgi apparatus GO:0005794 IEA
    cytosol GO:0005829 TAS
    microtubule GO:0005874 IEA
    cytoplasmic vesicle membrane GO:0030659 IEA
 Experiment description of studies that identified GABARAPL1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GABARAPL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 HBB 3043
Affinity Capture-MS Homo sapiens
3 TNIP1 10318
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 TBC1D10A 83874
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 CHRNA4  
Affinity Capture-MS Homo sapiens
6 TBC1D2 55357
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 ZBTB22  
Two-hybrid Homo sapiens
8 LLGL1 3996
Affinity Capture-MS Homo sapiens
9 SRPK2 6733
Biochemical Activity Homo sapiens
10 TBC1D16  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 STRN3 29966
Two-hybrid Homo sapiens
12 CALCOCO1 57658
Affinity Capture-Western Homo sapiens
13 BNIP3L  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
14 RABGAP1L 9910
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 ATG4C  
Affinity Capture-MS Homo sapiens
16 MEFV  
Reconstituted Complex Homo sapiens
17 APEX1 328
Affinity Capture-RNA Homo sapiens
18 KBTBD6  
Affinity Capture-MS Homo sapiens
19 UMAD1  
Two-hybrid Homo sapiens
20 PIK3CG  
Affinity Capture-MS Homo sapiens
21 STBD1 8987
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
22 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
23 SIRT1  
Affinity Capture-Western Homo sapiens
24 PTPRR  
Two-hybrid Homo sapiens
25 CLINT1 9685
Affinity Capture-MS Homo sapiens
26 ATG7 10533
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
27 ATG4D  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
28 WDFY3 23001
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
29 VDR  
Two-hybrid Homo sapiens
30 NEDD4 4734
Affinity Capture-MS Homo sapiens
31 DVL2 1856
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 PRNP 5621
Affinity Capture-MS Homo sapiens
33 TBC1D1 23216
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
34 CCT2 10576
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
35 TBC1D17 79735
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
36 TP53INP1  
Two-hybrid Homo sapiens
37 S100A2 6273
Co-fractionation Homo sapiens
38 ATG4A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 PSMB4 5692
Two-hybrid Homo sapiens
40 OPRK1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
41 CREB3L2 64764
Two-hybrid Homo sapiens
42 RB1CC1 9821
Affinity Capture-Western Homo sapiens
43 AMFR 267
Affinity Capture-MS Homo sapiens
44 NBR1 4077
Affinity Capture-Western Homo sapiens
45 OPTN 10133
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
46 FUNDC1  
Two-hybrid Homo sapiens
47 NFIA 4774
Two-hybrid Homo sapiens
48 PBXIP1 57326
Two-hybrid Homo sapiens
49 GABARAP 11337
Affinity Capture-MS Homo sapiens
50 TRIM21 6737
Reconstituted Complex Homo sapiens
51 GYS1 2997
Affinity Capture-MS Homo sapiens
52 MLX  
Two-hybrid Homo sapiens
53 TBC1D5 9779
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
54 ULK1  
Affinity Capture-Western Homo sapiens
55 NIPSNAP1 8508
Affinity Capture-MS Homo sapiens
56 SRPK1 6732
Biochemical Activity Homo sapiens
57 KRTAP10-7  
Two-hybrid Homo sapiens
58 DISC1 27185
Two-hybrid Homo sapiens
59 BSCL2  
Two-hybrid Homo sapiens
60 STK3 6788
Reconstituted Complex Homo sapiens
61 WDR11 55717
Affinity Capture-MS Homo sapiens
62 IPO5 3843
Affinity Capture-MS Homo sapiens
63 HADHB 3032
Affinity Capture-MS Homo sapiens
64 HADHA 3030
Affinity Capture-MS Homo sapiens
65 TAX1BP1 8887
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
66 AMBRA1  
Protein-peptide Homo sapiens
67 XPO1 7514
Affinity Capture-MS Homo sapiens
68 CCT6A 908
Affinity Capture-Western Homo sapiens
69 TBC1D10B 26000
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
70 PRKAR1A 5573
Affinity Capture-MS Homo sapiens
71 CUL3 8452
Affinity Capture-MS Homo sapiens
72 TMEM160 54958
Affinity Capture-MS Homo sapiens
73 KRTAP10-3  
Two-hybrid Homo sapiens
74 RABGAP1 23637
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
75 PI4K2A 55361
Affinity Capture-MS Homo sapiens
76 KBTBD7  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
77 NXF1 10482
Affinity Capture-RNA Homo sapiens
78 PRKCI 5584
Affinity Capture-MS Homo sapiens
79 DYX1C1  
Affinity Capture-MS Homo sapiens
80 FAM134C 162427
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
81 RAB11B 9230
Affinity Capture-MS Homo sapiens
82 RCN2 5955
Two-hybrid Homo sapiens
83 AHNAK2 113146
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
84 TBC1D9B 23061
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
85 MAPK15  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
86 NSMAF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 TBC1D25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
88 GBAS 2631
Affinity Capture-MS Homo sapiens
89 SNCA 6622
Reconstituted Complex Homo sapiens
90 BSDC1 55108
Two-hybrid Homo sapiens
91 SCYL3 57147
Two-hybrid Homo sapiens
92 TBC1D7  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
93 TBC1D9  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
94 ATG13 9776
Affinity Capture-Western Homo sapiens
95 NUFIP2 57532
Reconstituted Complex Homo sapiens
96 KEAP1 9817
Affinity Capture-MS Homo sapiens
97 GABARAPL2 11345
Affinity Capture-MS Homo sapiens
98 TTBK1  
Affinity Capture-MS Homo sapiens
99 SQSTM1 8878
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
100 G3BP1 10146
Reconstituted Complex Homo sapiens
101 TBC1D2B 23102
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
102 DDX58 23586
Affinity Capture-RNA Homo sapiens
103 THAP7  
Two-hybrid Homo sapiens
104 MAP1LC3A 84557
Co-localization Homo sapiens
105 MOV10 4343
Affinity Capture-RNA Homo sapiens
106 SEC62 7095
Affinity Capture-MS Homo sapiens
107 ATG4B 23192
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
108 KXD1 79036
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
109 NEK9 91754
Affinity Capture-MS Homo sapiens
110 ATG2A  
Affinity Capture-MS Homo sapiens
111 ATG3 64422
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
112 ALDOA 226
Co-fractionation Homo sapiens
113 KRTAP10-9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GABARAPL1 is involved
PathwayEvidenceSource
Autophagy TAS Reactome
Macroautophagy TAS Reactome





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