Gene description for CREB3L2
Gene name cAMP responsive element binding protein 3-like 2
Gene symbol CREB3L2
Other names/aliases BBF2H7
Species Homo sapiens
 Database cross references - CREB3L2
ExoCarta ExoCarta_64764
Vesiclepedia VP_64764
Entrez Gene 64764
HGNC 23720
MIM 608834
UniProt Q70SY1  
 CREB3L2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for CREB3L2
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IMP
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    cAMP response element binding GO:0035497 IBA
    cAMP response element binding GO:0035497 IMP
Biological Process
    chondrocyte differentiation GO:0002062 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IEA
    response to unfolded protein GO:0006986 IEA
    response to endoplasmic reticulum stress GO:0034976 IEP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    cartilage development GO:0051216 ISS
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified CREB3L2 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for CREB3L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PXN 5829
Two-hybrid Homo sapiens
2 GAS7  
Two-hybrid Homo sapiens
3 FBXW7  
Affinity Capture-MS Homo sapiens
4 GCFC2  
Two-hybrid Homo sapiens
5 ZNF212  
Two-hybrid Homo sapiens
6 Dynll1 56455
Affinity Capture-MS Mus musculus
7 RGS16 6004
Two-hybrid Homo sapiens
8 GABARAPL1 23710
Two-hybrid Homo sapiens
9 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
10 Fbxw7  
Affinity Capture-Western Mus musculus
Biochemical Activity Mus musculus
Affinity Capture-MS Mus musculus
11 CEP19  
Two-hybrid Homo sapiens
12 PTP4A1 7803
Two-hybrid Homo sapiens
13 CREB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
15 CREB3L3  
Affinity Capture-MS Homo sapiens
16 RND1  
Two-hybrid Homo sapiens
17 FAS 355
Proximity Label-MS Homo sapiens
18 GULP1 51454
Two-hybrid Homo sapiens
19 CREB3L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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