Gene description for CREB3L2
Gene name cAMP responsive element binding protein 3-like 2
Gene symbol CREB3L2
Other names/aliases BBF2H7
Species Homo sapiens
 Database cross references - CREB3L2
ExoCarta ExoCarta_64764
Entrez Gene 64764
HGNC 23720
MIM 608834
UniProt Q70SY1  
 CREB3L2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for CREB3L2
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IEA
    transcription regulatory region DNA binding GO:0044212 IMP
    cAMP response element binding GO:0035497 IMP
Biological Process
    ER to Golgi vesicle-mediated transport GO:0006888 IEA
    response to endoplasmic reticulum stress GO:0034976 IEP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    chondrocyte differentiation GO:0002062 ISS
    transcription, DNA-templated GO:0006351 IEA
    cartilage development GO:0051216 ISS
    endoplasmic reticulum unfolded protein response GO:0030968 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    integral component of membrane GO:0016021 IEA
    nucleus GO:0005634 IDA
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified CREB3L2 in exosomes
Experiment ID 226
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for CREB3L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CREB3L2 is involved
No pathways found

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