Gene description for Dynll1
Gene name dynein light chain LC8-type 1
Gene symbol Dynll1
Other names/aliases Dlc8
Dnclc1
Pin
Species Mus musculus
 Database cross references - Dynll1
ExoCarta ExoCarta_56455
Entrez Gene 56455
UniProt P63168  
 Dynll1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dynll1
Molecular Function
    protein binding GO:0005515 IPI
    motor activity GO:0003774 IEA
    protein C-terminus binding GO:0008022 IPI
    nitric-oxide synthase regulator activity GO:0030235 ISO
    enzyme inhibitor activity GO:0004857 ISO
    protein domain specific binding GO:0019904 IPI
    enzyme binding GO:0019899 ISO
    protein homodimerization activity GO:0042803 ISO
Biological Process
    microtubule-based process GO:0007017 IEA
    intraciliary retrograde transport GO:0035721 IMP
    negative regulation of catalytic activity GO:0043086 ISO
    microtubule-based movement GO:0007018 TAS
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    cilium morphogenesis GO:0060271 IMP
    apoptotic process GO:0006915 IEA
    negative regulation of nitric oxide biosynthetic process GO:0045019 ISO
    regulation of catalytic activity GO:0050790 ISO
    transport GO:0006810 IEA
    negative regulation of phosphorylation GO:0042326 ISO
Subcellular Localization
    cytoplasmic dynein complex GO:0005868 ISO
    mitochondrion GO:0005739 IEA
    COP9 signalosome GO:0008180 ISO
    cilium GO:0005929 IMP
    cytosol GO:0005829 IDA
    cytoskeleton GO:0005856 IDA
    mitotic spindle GO:0072686 ISO
    kinetochore GO:0000776 ISO
    microtubule associated complex GO:0005875 IEA
    membrane GO:0016020 ISO
    centrosome GO:0005813 ISO
    dynein complex GO:0030286 IEA
    microtubule GO:0005874 IEA
    intracellular GO:0005622 IMP
    cell GO:0005623 IMP
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Dynll1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dynll1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NRF1 4899
Two-hybrid Homo sapiens
View the network image/svg+xml



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