Gene description for Dynll1
Gene name dynein light chain LC8-type 1
Gene symbol Dynll1
Other names/aliases Dlc8
Dnclc1
Pin
Species Mus musculus
 Database cross references - Dynll1
ExoCarta ExoCarta_56455
Vesiclepedia VP_56455
Entrez Gene 56455
UniProt P63168  
 Dynll1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dynll1
Molecular Function
    enzyme inhibitor activity GO:0004857 ISO
    enzyme inhibitor activity GO:0004857 ISS
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 ISO
    protein domain specific binding GO:0019904 IPI
    nitric-oxide synthase regulator activity GO:0030235 ISO
    nitric-oxide synthase inhibitor activity GO:0036487 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 ISO
    dynein intermediate chain binding GO:0045505 IBA
    dynein intermediate chain binding GO:0045505 IPI
    deoxyribonuclease inhibitor activity GO:0060703 ISO
    scaffold protein binding GO:0097110 ISO
Biological Process
    apoptotic process GO:0006915 IEA
    DNA damage response GO:0006974 IEA
    intraciliary retrograde transport GO:0035721 IBA
    intraciliary retrograde transport GO:0035721 IMP
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 ISO
    negative regulation of phosphorylation GO:0042326 ISO
    motile cilium assembly GO:0044458 IBA
    motile cilium assembly GO:0044458 IMP
    negative regulation of nitric oxide biosynthetic process GO:0045019 ISO
    negative regulation of nitric oxide biosynthetic process GO:0045019 ISO
    regulation of mitochondrial membrane potential GO:0051881 IMP
    negative regulation of DNA strand resection involved in replication fork processing GO:0110027 ISO
    negative regulation of DNA strand resection involved in replication fork processing GO:0110027 ISS
    mitocytosis GO:0160040 IMP
    positive regulation of non-motile cilium assembly GO:1902857 IGI
    positive regulation of non-motile cilium assembly GO:1902857 IMP
Subcellular Localization
    kinetochore GO:0000776 ISO
    kinetochore GO:0000776 ISS
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IEA
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    cytosol GO:0005829 IDA
    cytoskeleton GO:0005856 IDA
    cytoskeleton GO:0005856 ISO
    cytoplasmic dynein complex GO:0005868 IBA
    cytoplasmic dynein complex GO:0005868 IPI
    cytoplasmic dynein complex GO:0005868 ISA
    cytoplasmic dynein complex GO:0005868 ISO
    cytoplasmic dynein complex GO:0005868 ISS
    microtubule GO:0005874 IEA
    cilium GO:0005929 IEA
    COP9 signalosome GO:0008180 ISO
    membrane GO:0016020 IDA
    secretory granule GO:0030141 ISO
    dynein complex GO:0030286 IDA
    dynein complex GO:0030286 ISO
    site of double-strand break GO:0035861 ISO
    site of double-strand break GO:0035861 ISS
    mitotic spindle GO:0072686 ISO
    mitotic spindle GO:0072686 ISS
    axon cytoplasm GO:1904115 ISO
 Experiment description of studies that identified Dynll1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dynll1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STK25 10494
Affinity Capture-MS Homo sapiens
2 HDAC2 3066
Affinity Capture-MS Homo sapiens
3 CREB3L2 64764
Affinity Capture-MS Homo sapiens
4 TLK2  
Affinity Capture-MS Homo sapiens
5 DYNC1I2 1781
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 MTPAP 55149
Affinity Capture-MS Homo sapiens
7 Sec13 110379
Co-fractionation Mus musculus
8 Fmr1  
Affinity Capture-MS Mus musculus
9 MPO 4353
Affinity Capture-MS Homo sapiens
10 DYNC1I1  
Two-hybrid Homo sapiens
11 STRN3 29966
Affinity Capture-MS Homo sapiens
12 Dync1li2  
Co-fractionation Mus musculus
13 HMMR  
Affinity Capture-MS Homo sapiens
14 Slc44a2 68682
Co-fractionation Mus musculus
15 PDCD10 11235
Affinity Capture-MS Homo sapiens
16 MASTL  
Affinity Capture-MS Homo sapiens
17 STRN 6801
Affinity Capture-MS Homo sapiens
18 DYNC1LI2 1783
Affinity Capture-MS Homo sapiens
19 SOGA1 140710
Affinity Capture-MS Homo sapiens
20 GPHN 10243
Affinity Capture-MS Homo sapiens
21 AGGF1  
Affinity Capture-MS Homo sapiens
22 FAM83D 81610
Affinity Capture-MS Homo sapiens
23 TLK1  
Affinity Capture-MS Homo sapiens
24 Mapt  
Affinity Capture-MS Mus musculus
25 Atg16l1  
Affinity Capture-MS Mus musculus
26 DYNLL1 8655
Affinity Capture-MS Homo sapiens
27 STRIP1 85369
Affinity Capture-MS Homo sapiens
28 Fxr1 14359
Affinity Capture-MS Mus musculus
29 EML3 256364
Affinity Capture-MS Homo sapiens
30 KNSTRN  
Affinity Capture-MS Homo sapiens
31 CTTNBP2NL  
Affinity Capture-MS Homo sapiens
32 RCOR3  
Affinity Capture-MS Homo sapiens
33 LARP4B 23185
Two-hybrid Homo sapiens
34 SPAG5 10615
Affinity Capture-MS Homo sapiens
35 MOB4 25843
Affinity Capture-MS Homo sapiens
36 Ndel1  
Two-hybrid Mus musculus
37 ZMYM3  
Affinity Capture-MS Homo sapiens
38 Ambra1 228361
Affinity Capture-Western Mus musculus
39 DCAF7 10238
Affinity Capture-MS Homo sapiens
40 PPP2CA 5515
Affinity Capture-MS Homo sapiens
41 DYNLL2 140735
Affinity Capture-MS Homo sapiens
42 Ube2i  
Two-hybrid Mus musculus
43 ZNF609  
Affinity Capture-MS Homo sapiens
44 NRF1 4899
Two-hybrid Homo sapiens
45 ZMYM4  
Affinity Capture-MS Homo sapiens
46 HADHB 3032
Two-hybrid Homo sapiens
47 DEFA1 1667
Affinity Capture-MS Homo sapiens
48 TP53BP1 7158
Affinity Capture-MS Homo sapiens
49 AMBRA1  
Affinity Capture-MS Homo sapiens
50 PIP 5304
Affinity Capture-MS Homo sapiens
51 PRKAR2A 5576
Affinity Capture-MS Homo sapiens
52 GLCCI1 113263
Affinity Capture-MS Homo sapiens
53 Pcbp1 23983
Two-hybrid Mus musculus
54 IFFO2 126917
Affinity Capture-MS Homo sapiens
55 WDR34 89891
Affinity Capture-MS Homo sapiens
56 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
57 WDR60 55112
Affinity Capture-MS Homo sapiens
58 DYNC1LI1 51143
Affinity Capture-MS Homo sapiens
59 Trps1 83925
Two-hybrid Mus musculus
60 Eed  
Affinity Capture-MS Mus musculus
61 ZMYM2  
Affinity Capture-MS Homo sapiens
62 PPP2CB 5516
Affinity Capture-MS Homo sapiens
63 Clnk  
Co-fractionation Mus musculus
64 PIGR 5284
Affinity Capture-MS Homo sapiens
65 SNCA 6622
Affinity Capture-MS Homo sapiens
66 NEK9 91754
Affinity Capture-MS Homo sapiens
67 UHRF1BP1L 23074
Affinity Capture-MS Homo sapiens
68 TRPS1  
Affinity Capture-MS Homo sapiens
69 STRN4 29888
Affinity Capture-MS Homo sapiens
70 KANK1  
Affinity Capture-MS Homo sapiens
71 Atxn1  
Affinity Capture-MS Mus musculus
72 SKP1 6500
Affinity Capture-MS Homo sapiens
73 Ckap5 75786
Co-fractionation Mus musculus
74 STK26 51765
Affinity Capture-MS Homo sapiens
75 Iqcb1  
Affinity Capture-MS Mus musculus
76 MORC3 23515
Affinity Capture-MS Homo sapiens
77 Mettl21e  
Affinity Capture-MS Mus musculus
78 Zfp207  
Co-fractionation Mus musculus
79 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
80 KDM1A 23028
Affinity Capture-MS Homo sapiens
81 FBXO30 84085
Affinity Capture-MS Homo sapiens
82 FAM172A  
Affinity Capture-MS Homo sapiens
83 DYNLRB1 83658
Affinity Capture-MS Homo sapiens
84 KANK2 25959
Affinity Capture-MS Homo sapiens
85 CIZ1  
Affinity Capture-MS Homo sapiens
86 MTCL1 23255
Affinity Capture-MS Homo sapiens
87 LTF 4057
Affinity Capture-MS Homo sapiens
88 FBXO38 81545
Affinity Capture-MS Homo sapiens
89 RCOR1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Dynll1 is involved
PathwayEvidenceSource
Activation of BH3-only proteins IEA Reactome
Activation of BIM and translocation to mitochondria IEA Reactome
Adaptive Immune System IEA Reactome
Aggrephagy IEA Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal IEA Reactome
Amplification of signal from the kinetochores IEA Reactome
Anchoring of the basal body to the plasma membrane IEA Reactome
Apoptosis IEA Reactome
Asparagine N-linked glycosylation IEA Reactome
AURKA Activation by TPX2 IEA Reactome
Autophagy IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Centrosome maturation IEA Reactome
Cilium Assembly IEA Reactome
COPI-independent Golgi-to-ER retrograde traffic IEA Reactome
COPI-mediated anterograde transport IEA Reactome
EML4 and NUDC in mitotic spindle formation IEA Reactome
ER to Golgi Anterograde Transport IEA Reactome
G2/M Transition IEA Reactome
Golgi-to-ER retrograde transport IEA Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic IEA Reactome
Intraflagellar transport IEA Reactome
Intrinsic Pathway for Apoptosis IEA Reactome
Loss of Nlp from mitotic centrosomes IEA Reactome
Loss of proteins required for interphase microtubule organization from the centrosome IEA Reactome
M Phase IEA Reactome
Macroautophagy IEA Reactome
Membrane Trafficking IEA Reactome
Metabolism of proteins IEA Reactome
MHC class II antigen presentation IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Spindle Checkpoint IEA Reactome
Neutrophil degranulation IEA Reactome
Organelle biogenesis and maintenance IEA Reactome
Post-translational protein modification IEA Reactome
Programmed Cell Death IEA Reactome
Recruitment of mitotic centrosome proteins and complexes IEA Reactome
Recruitment of NuMA to mitotic centrosomes IEA Reactome
Regulation of PLK1 Activity at G2/M Transition IEA Reactome
Resolution of Sister Chromatid Cohesion IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
Selective autophagy IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Transport to the Golgi and subsequent modification IEA Reactome
Vesicle-mediated transport IEA Reactome





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