Gene description for Trps1
Gene name trichorhinophalangeal syndrome I (human)
Gene symbol Trps1
Other names/aliases AI115454
AI447310
D15Ertd586e
Species Mus musculus
 Database cross references - Trps1
ExoCarta ExoCarta_83925
Entrez Gene 83925
 Trps1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trps1
Molecular Function
    DNA binding GO:0003677 IEA
    metal ion binding GO:0046872 IEA
    zinc ion binding GO:0008270 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IPI
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    regulation of chondrocyte differentiation GO:0032330 IMP
    chondrocyte differentiation GO:0002062 IGI
    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 IGI
    transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 IGI
    regulation of histone deacetylation GO:0031063 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Trps1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trps1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trps1 is involved
No pathways found





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