Gene description for Trpm2
Gene name transient receptor potential cation channel, subfamily M, member 2
Gene symbol Trpm2
Other names/aliases 9830168K16Rik
C79133
LTRPC2
TRPC7
Trp7
Trrp7
Species Mus musculus
 Database cross references - Trpm2
ExoCarta ExoCarta_28240
Entrez Gene 28240
 Trpm2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trpm2
Molecular Function
    hydrolase activity GO:0016787 IEA
    ADP-ribose diphosphatase activity GO:0047631 IEA
    ion channel activity GO:0005216 IEA
    calcium channel activity GO:0005262 IEA
    sodium channel activity GO:0005272 IEA
    manganese ion transmembrane transporter activity GO:0005384 IDA
    cation channel activity GO:0005261 IEA
Biological Process
    transport GO:0006810 IEA
    manganese ion transmembrane transport GO:0071421 IDA
    calcium ion transport GO:0006816 IEA
    ion transmembrane transport GO:0034220 IEA
    transmembrane transport GO:0055085 IEA
    response to hydroperoxide GO:0033194 IDA
    ion transport GO:0006811 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    response to oxidative stress GO:0006979 IEA
    positive regulation of oxidative stress-induced neuron death GO:1903223 ISO
    manganese ion transport GO:0006828 IDA
    positive regulation of insulin secretion GO:0032024 ISO
    sodium ion transport GO:0006814 IEA
    cation transport GO:0006812 IEA
    calcium ion import across plasma membrane GO:0098703 ISO
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    intracellular GO:0005622 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IEA
    neuronal cell body GO:0043025 ISO
    neuron projection GO:0043005 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Trpm2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trpm2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trpm2 is involved
No pathways found





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